Selenium-Catalyzed Carbonylative Synthesis of 3,4-Dihydroquinazolin-2(1 H)-one Derivatives with TFBen as the CO Source [0.03%]
三氟苯作为碳酸源的硒催化羰基化合成3，4-二氢喹唑啉-2（1H）-酮衍生物反应研究
Rong Zhou,Xinxin Qi,Xiao-Feng Wu
Rong Zhou
An efficient and general carbonylative procedure for the synthesis of 3,4-dihydroquinazolin-2(1H)-one from 1-(halomethyl)-2-nitrobenzenes and aryl/alkyl amines have been explored. In this approach, to avoid of using toxic CO gas, a solid an...
On-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water [0.03%]
DNA上的脱羧芳基化：在水中的光氧化还原与镍催化的融合
Dominik K Kölmel,Jiang Meng,Mei-Hsuan Tsai et al.
Dominik K Kölmel et al.
A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine...
Matthew T Holden,Lloyd M Smith
Matthew T Holden
Counterfeiting is an incredibly widespread problem, with some estimates placing its economic impact above 2% of worldwide GDP. The scale of the issue suggests that current preventive measures are either technologically insufficient or too i...
Parisa Zamani,Joshua Phipps,Jiyun Hu et al.
Parisa Zamani et al.
A practical and efficient synthetic procedure to novel chromeno[3,2-d]oxazoles through a one-pot sequential multistep process is presented. This procedure proceeds efficiently in propylene carbonate (PC) as a green solvent and affords a wid...
High-Affinity α5β1-Integrin-Selective Bicyclic RGD Peptides Identified via Screening of Designed Random Libraries [0.03%]
通过筛选设计的随机库获得高亲和力α5β1整合素选择性双环RGD肽
Dominik Bernhagen,Vanessa Jungbluth,Nestor Gisbert Quilis et al.
Dominik Bernhagen et al.
We report the identification of high-affinity and selectivity integrin α5β1-binding bicyclic peptides via "designed random libraries", that is, the screening of libraries comprising the universal integrin-binding sequence Arg-Gly-Asp (RGD...
Plasmonic Selection of ssDNA Aptamers against Fibroblast Growth Factor Receptor [0.03%]
基于等离激元筛选的成纤维细胞生长因子受体ssDNA适配体
Hasan Kurt,Alp Ertunga Eyüpoğlu,Tolga Sütlü et al.
Hasan Kurt et al.
In this work, we describe the selection of ssDNA aptamers targeting fibroblast growth factor receptor binding protein 3 K650E, which has roles in cell division, growth, and differentiation through the kinase cascade. The selection process w...
Synthesis of Arylamides via Ritter-Type Cleavage of Solid-Supported Aryltriazenes [0.03%]
通过固相亚胲基芳烃的Ritter型裂解合成芳酰胺
Nicolai A Wippert,Nicole Jung,Stefan Bräse
Nicolai A Wippert
A novel route for the synthesis of N-arylamides via the cleavage of aryltriazenes with alkyl or aryl nitriles is presented. We developed a variation of the Ritter reaction that allows the use of acetonitrile as solvent and reagent in reacti...
Peter Meier,Nicole Battaglia,Peter Ertl et al.
Peter Meier et al.
The production of two libraries based on spirocyclic indolinones is described. These libraries were selected from numerous spirocyclic indolinone scaffolds with a library evaluation procedure used routinely at Novartis, based on computed ph...
Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds [0.03%]
茋联吡啶配体和双联吡啶-𬭩盐：用于硫属元素催化的直接C-X官能团化反应的高效催化剂骨架构建单元的新方法：茋联吡啶配体和双联吡啶- ammonium 盐：硫属元素催化直接C-X官能团化的高效催化剂骨架构建单元
Sahar Majnooni,Joseph Duffield,Jessica Price et al.
Sahar Majnooni et al.
Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted...
Thin-Film Processing Routes for Combinatorial Materials Investigations-A Review [0.03%]
用于材料组合研究的薄膜加工路线综述
Paul J McGinn
Paul J McGinn
High-throughput combinatorial investigations are transforming materials discovery, phase diagram development, and processing optimization. Thin-film deposition techniques are frequently used to fabricate sample libraries employed in these s...