Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides [0.03%]
多组分方法构建取代二氢尿酸酰胺类化合物库
Maria Cristina Bellucci,Alessandro Sacchetti,Alessandro Volonterio
Maria Cristina Bellucci
A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N'-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for ...
Olena Savych,Yuliya O Kuchkovska,Andrey V Bogolyubsky et al.
Olena Savych et al.
Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as t...
Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4 H-pyran-3,5-dicarbonitrile Derivatives [0.03%]
可见光促进的三组分“一锅法”合成2-氨基-4H-吡喃并[2,3-c]嘧啶-3,5-二腈类化合物
Mo Zhang,Meng-Nan Chen,Jiao-Mian Li et al.
Mo Zhang et al.
A novel approach for the visible-light-initiated synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives via a one-pot, three-component reaction of aldehydes or isatins, malononitrile, and α-cyano ketones has been developed. The react...
Diastereoselective Synthesis of 3,4-Dihydropyran-3-carboxamides with in Vitro Anti-inflammatory Activity [0.03%]
具有抗炎活性的3,4-二氢吡喃-3-羧酰胺的非对映选择性合成
Li-Yan Zeng,Baomin Xi,Kaiqi Huang et al.
Li-Yan Zeng et al.
A versatile and economical reaction of diketene (1), aryl amines 2, cyclic 1,3-diketones 3, primary amines 4, and aryl aldehydes 5 was explored to synthesize 3,4-dihydropyran-3-carboxamide derivatives under mild conditions. Three stereogeni...
A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis [0.03%]
基于DNA编码化合物库合成的化学反应兼容性特征解决方案相平台
Anokha S Ratnayake,Mark E Flanagan,Timothy L Foley et al.
Anokha S Ratnayake et al.
DNA-encoded chemical library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the identification of "DNA-compatible" reaction conditions is critical for the development...
Energy-Geometry Dependency of Molecular Structures: A Multistep Machine Learning Approach [0.03%]
分子结构的能-几何依赖性的多步机器学习方法研究
Ehsan Moharreri,Maryam Pardakhti,Ranjan Srivastava et al.
Ehsan Moharreri et al.
There is growing interest in estimating quantum observables while circumventing expensive computational overhead for facile in silico materials screening. Machine learning (ML) methods are implemented to perform such calculations in shorter...
Energy-Geometry Dependency of Molecular Structures: A Multistep Machine Learning Approach [0.03%]
分子结构的能量-几何依赖性的多步机器学习方法研究
Ehsan Moharreri,Maryam Pardakhti,Ranjan Srivastava et al.
Ehsan Moharreri et al.
There is growing interest in estimating quantum observables while circumventing expensive computational overhead for facile in silico materials screening. Machine learning (ML) methods are implemented to perform such calculations in shorter...
Parallel Solution Phase Synthesis and Preliminary Biological Activity of a 5'-Substituted Cytidine Analog Library [0.03%]
一组5'-位取代胞苷类似物的并行合成及初步生物活性测试
Omar Moukha-Chafiq,Robert C Reynolds,Jacob C Wilson et al.
Omar Moukha-Chafiq et al.
A 109-membered library of 5'-substituted cytidine analogs was synthesized, via funding through the NIH Roadmap Initiative and the Pilot Scale Library (PSL) Program. Reaction core compounds contained -NH2 (2) and -COOH (44 and 93) groups tha...
A Tyrosinase Inhibitor from a Nitrogen-Enriched Chemically Engineered Extract [0.03%]
一种氮添加化学改性提取物的酪氨酸酶抑制剂
Carlos M Solís,Mario O Salazar,I Ayelen Ramallo et al.
Carlos M Solís et al.
The enzyme tyrosinase is involved in the biosynthesis of melanin and the enzymatic browning of fruits and vegetables, and therefore, its inhibitors have potential to treat hyperpigmentary disorders or to function as food antibrowning agents...
Overview of Analytical-to-Preparative Liquid Chromatography Method Development [0.03%]
从分析到制备型液相色谱方法的开发概述
Jack Silver
Jack Silver
Purification of compounds is a necessary aspect of chemical synthesis. Developing an efficient purification method is time-consuming. A method that quickly calculates preparative gradients from analytical scouting runs is described. A solve...