Beyond Epitope Binning: Directed in Vitro Selection of Complementary Pairs of Binding Proteins [0.03%]
表位分箱之外：结合蛋白互补对的定向体外选择
Eric A Miller,Ki-Joo Sung,Patthara Kongsuphol et al.
Eric A Miller et al.
Many biotechnological applications require the simultaneous binding of affinity reagents to nonoverlapping target epitopes, the most prominent example being sandwich immunoassays. Typically, affinity pairs are identified via post facto func...
One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines [0.03%]
不对称双杂环的一锅合成：含苯并咪唑、苯并噁唑和苯并噻唑的噻唑烷𬭩盐的新合成方法
Hsueh-Yuan Lu,Indrajeet J Barve,Manikandan Selvaraju et al.
Hsueh-Yuan Lu et al.
A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course...
FTO Darkening Rate as a Qualitative, High-Throughput Mapping Method for Screening Li-Ionic Conduction in Thin Solid Electrolytes [0.03%]
基于FTO着色速率的锂离子导电薄固态电解质高通量筛选定性方法
Shay Tirosh,Niv Aloni,Simcha Meir et al.
Shay Tirosh et al.
We present a high-throughput (combinatorial) method to screen thin ceramic films as Li-ion conductors by mapping an optical effect of Li-ion conduction. The method, while qualitative, is fast and simple to implement, provides a planar (XY) ...
Interfacial Interaction between Suolunite Crystal and Silica Binding Peptide for Novel Bioinspired Cement [0.03%]
索鲁尼特晶体与硅结合肽之间的界面相互作用的新型仿生水泥研究
Wai-Yim Ching,Lokendra Poudel,Saro San et al.
Wai-Yim Ching et al.
Cement and concrete have been important construction materials throughout human history. There is an urgent need to explore novel and untraditional cementitious materials to enhance the durability of building materials and structures in res...
Screening Yeast Display Libraries against Magnetized Yeast Cell Targets Enables Efficient Isolation of Membrane Protein Binders [0.03%]
磁化酵母细胞靶点的筛选 yeast display 文库实现高效获得膜蛋白结合分子
Kaitlyn Bacon,Matthew Burroughs,Abigail Blain et al.
Kaitlyn Bacon et al.
When isolating binders from yeast displayed combinatorial libraries, a soluble, recombinantly expressed form of the target protein is typically utilized. As an alternative, we describe the use of target proteins displayed as surface fusions...
Effects of the Ion to Growth Flux Ratio on the Constitution and Mechanical Properties of Cr1- x-Alx-N Thin Films [0.03%]
离子掺入生长速率比对Cr1-xAlxN薄膜组成及力学性能的影响
Lars Banko,Stefan Ries,Dario Grochla et al.
Lars Banko et al.
Cr-Al-N thin film materials libraries were synthesized by combinatorial reactive high power impulse magnetron sputtering (HiPIMS). Different HiPIMS repetition frequencies and peak power densities were applied altering the ion to growth flux...
Benzimidazolyl-pyrazolo[3,4- b]pyridinones, Selective Inhibitors of MOLT-4 Leukemia Cell Growth and Sea Urchin Embryo Spiculogenesis: Target Quest [0.03%]
含苯并咪唑基吡唑并[3,4-b]吡啶酮类化合物：对MOLT-4白血病细胞生长和海胆胚棘发生具有选择性抑制作用及靶点探索的取代产物
Boris V Lichitsky,Andrey N Komogortsev,Arkady A Dudinov et al.
Boris V Lichitsky et al.
1,3-Substituted pyrazolo[3,4-b]pyridinones 11-18 were synthesized by a three-component condensation of Meldrum's acid with aryl aldehydes and 1,3-substituted 5-aminopyrazoles. Their biological activity was evaluated using the in vivo phenot...
An Improved High-Throughput Data Processing Based on Combinatorial Materials Chip Approach for Rapid Construction of Fe-Cr-Ni Composition-Phase Map [0.03%]
基于组合材料芯片方法的改进高通量数据处理在Fe-Cr-Ni成分配相图快速构建中的应用研究
Zhaoyang Zhao,Ying Jin,Peng Shi et al.
Zhaoyang Zhao et al.
The combinatorial materials chip approach is vastly superior to the conventional one that characterizes one sample at a time in the efficiency of composition-phase map construction. However, the resolution of its high-throughput characteriz...
Kiran Vaddi,Olga Wodo
Kiran Vaddi
Materials design and discovery through the high-throughput exploration of materials space has been recognized as a new paradigm in materials science. However, typical high-throughput exploration methods deliver high-dimensional and very div...
Semiautomated Parallel RAFT Copolymerization of Isoprene with Glycidyl Methacrylate [0.03%]
异戊二烯与甘油基甲基丙烯酸酯的半自动平行RAFT共聚
Miguel Rosales-Guzmán,Odilia Pérez-Camacho,Carlos Guerrero-Sánchez et al.
Miguel Rosales-Guzmán et al.
Copolymerization of isoprene (IP) with glycidyl methacrylate (GMA) was performed under RAFT (reversible addition-fragmentation chain-transfer) polymerization conditions in a platform for high-output experimentation. Covering the range betwe...