Carbon-ion beam irradiation combined with miR-17-5p/miR-17-3p inhibitors effectively kill osteosarcoma cells [0.03%]
碳离子束照射结合抑制miR-17-5p/miR-17-3p有效杀死成骨肉瘤细胞
Eun Ho Kim,Won Seok Lee,Sei Sai
Eun Ho Kim
Osteosarcoma (OS) is the most common type of bone cancer and is highly resistant to conventional photon beam radiotherapy; however, carbon-ion radiotherapy (CIRT) is effective in treating OS. In this study, to investigate whether miR-17-5p/...
TNFAIP1 suppresses hepatocellular carcinoma progression via the PXR/CYP3A4 signaling axis [0.03%]
TNFAIP1通过PXR/CYP3A4信号轴抑制肝细胞癌进展
Qian Nie,Yiping Guo,Haowen Xiao et al.
Qian Nie et al.
Hepatocellular carcinoma (HCC) is characterized by poor prognosis and limited effective treatment options, necessitating a deeper understanding of its pathogenesis. This study focuses on tumor necrosis factor-α-induced protein 1 (TNFAIP1) ...
Precision chemotherapy duration in advanced ovarian cancer: neoadjuvant cycle optimization and differential treatment adaptation by cytoreduction outcome [0.03%]
晚期卵巢癌精准化疗周期优化及减瘤效果导向的个体化治疗调整策略研究
Wan-Ting Lin,Chen-Hsuan Wu,Hao Lin et al.
Wan-Ting Lin et al.
This retrospective study evaluated the impact of neoadjuvant chemotherapy (NACT) cycle number and total chemotherapy (TCT) cycle number on survival and surgical outcomes in patients with advanced epithelial ovarian cancer undergoing interva...
Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME [0.03%]
异巴瓦青素通过调节PARP和GSDME的半胱天冬酶介导的切割在分化型甲状腺癌细胞中诱导并发凋亡和炎性坏死(pyroptosis)
Chuanming Zheng,Aoni Zhou,Lingling Ding et al.
Chuanming Zheng et al.
Anaplastic thyroid carcinoma (ATC) is a highly lethal malignant tumor, and there's still no effective treatment for it. Isobavachalcone (IBC) is a chalcone derivative and comes from the traditional Chinese herb Psoralea corylifolia. IBC exh...
CBX3 promotes epithelial-mesenchymal transition in synovial sarcoma via the SHH signaling pathway [0.03%]
CBX3通过SHH信号通路促进滑膜肉瘤上皮间质转化
Yachao Sun,Zhibing Dai,Junwei Du et al.
Yachao Sun et al.
Synovial sarcoma (SS) is a malignant mesenchymal tumor of uncertain histogenesis, representing approximately 5% to 10% of all soft tissue sarcomas. It predominantly affects adolescents and young adults. The role of CBX3 (Chromobox homolog 3...
THAP7-AS1 orchestrates IGF2BP3-m6A-dependent CCN2 mRNA stabilization to promote lymphatic metastasis in bladder cancer [0.03%]
THAP7-AS1通过IGF2BP3介导的CCN2 mRNA稳定促进膀胱癌淋巴转移
Qiuyan Li,Junjie Bai,Shiwen Zheng et al.
Qiuyan Li et al.
Lymphatic dissemination is a major cause of treatment failure in muscle-invasive bladder cancer (MIBC), yet the RNA circuits linking post-transcriptional regulation to lymphatic metastasis remain incompletely defined. Here, we identify THAP...
Early recurrence predicts poor post-recurrence survival in young breast cancer patients: development and validation of a prognostic nomogram [0.03%]
早期复发预示年轻乳腺癌患者较差的复发后生存：预后预测列线图的建立和验证
Yun Cai,Yi Liu,Ye Sun et al.
Yun Cai et al.
This retrospective cohort study aimed to investigate clinicopathological differences between early and late recurrence in young breast cancer patients aged 40 years or younger, identify independent prognostic factors for post-recurrence ove...
PDE4C stabilized by ELAVL1 promotes lymph node metastasis in papillary thyroid cancer [0.03%]
PDE4C由ELAVL1稳定，在乳头状甲状腺癌中促进淋巴结转移
Tingting Cui,Ying Zhang,Wanwan Li et al.
Tingting Cui et al.
Lymph node metastasis (LNM) is a key factor in the recurrence and progression of papillary thyroid carcinoma (PTC). Phosphodiesterase 4C (PDE4C) serves as a crucial regulator in cancer development and metastasis, its functional role and mec...
Inhibition of RAB7 promotes CD8+ T cell activation via the STING/IRF1/CCL5/CXCL10 signaling axis to promote PD-1-mediated anti-lung cancer efficacy [0.03%]
RAB7抑制通过STING/IRF1/CCL5/CXCL10信号轴促进CD8+T细胞活化以增强PD-1介导的抗肺癌效应
Xiaoli Liu,Zhiqiang Jiang,Ruijie Li et al.
Xiaoli Liu et al.
Programmed cell death protein 1 (PD-1) antibody is facing the challenge of drug resistance in cancer therapy. RAB7 plays a key role in autophagic lysosomal fusion, but its function in tumor immune regulation, especially whether it can enhan...
Comparative study on imaging characteristics of pilocytic astrocytomas in children and adolescents [0.03%]
儿童及青少年毛细胞星形细胞瘤的影像学特点比较研究
Yan Gao,Qing Liu,Hailing Liu et al.
Yan Gao et al.
This study investigated imaging differences of intracranial pilocytic astrocytomas (PA) between children and adolescents. We retrospectively analyzed imaging data from 19 children and 19 adolescents admitted to People's Hospital of Rizhao b...