Epigenetic reprogramming of hexokinase domain containing 1 (HKDC1) promotes proliferation in colorectal cancer [0.03%]
表观遗传重编程的己糖激酶结构域包含蛋白1(HKDC1)促进结直肠癌增殖
Kuo-Hsing Chen,Liang-Chuan Lai,Liang-In Lin et al.
Kuo-Hsing Chen et al.
Dysregulation of cellular metabolism is one of the hallmarks of cancer. Tumor cells would enhance glycolysis to fuel the phenotypes of rapid proliferation and invasion. This study aims to explore epigenetic reprogramming of glycolysis pathw...
UFM1 regulates ferroptosis in oral squamous cell carcinoma by stabilizing SLC7A11 [0.03%]
UFM1通过稳定SLC7A11调节口腔鳞状细胞癌的铁死亡
Gang Li,Hongwei Yang,Jing Guo
Gang Li
Oral squamous cell carcinoma (OSCC) is highly invasive malignancy with limited effective therapeutic strategies. Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like molecule that has been implicated in several cancers; however, its role in...
Real-world outcomes of consolidative radiotherapy following first-line chemo-immunotherapy in metastatic non-small cell lung cancer: a retrospective cohort study [0.03%]
一线化疗免疫治疗后序贯巩固放疗对晚期非小细胞肺癌患者真实世界疗效的回顾性队列研究
Zhian Qiao,Lin Pang,Hongxin Zheng
Zhian Qiao
The role and efficacy of consolidative radiotherapy (CRT) in patients with metastatic non-small cell lung cancer (mNSCLC) treated with first-line chemo-immunotherapy remain to be clarified. In this retrospective cohort study, we divided mNS...
Association between perioperative opioid consumption and postoperative outcomes in lung cancer surgery: evidence from a retrospective study with inflammatory and immune biomarker analysis [0.03%]
肺癌手术患者围术期阿片类药物消耗与术后结局的关联性分析：一项回顾性研究及其炎性和免疫生物标志物分析
Ruogen Li,Wuhua Ma
Ruogen Li
Opioids are crucial for lung cancer postoperative analgesia, but perioperative dosage-inflammation/immunity associations remain unclear. This study explores perioperative opioid use and inflammation/immunity biomarker changes in lung cancer...
Efficacy of chemotherapy combined with immune checkpoint inhibitors for advanced non-small cell lung cancer and construction and validation of a prognostic model: a multicenter retrospective cohort study [0.03%]
化疗联合免疫检查点抑制剂治疗晚期非小细胞肺癌的疗效及预后模型的构建与验证：一项多中心回顾性队列研究
Chunmei Gong,Fenghong Lv,Beibei Xiong et al.
Chunmei Gong et al.
The goal of this multicenter retrospective cohort study was to determine the efficacy of chemotherapy in combination with immune checkpoint inhibitors (ICIs) as compared to chemotherapy alone in patients with advanced non-small cell lung ca...
Ferroptosis and Ferroptosis-related autophagy: new therapeutic targets for gastric cancer [0.03%]
铁死亡及铁死亡相关自噬：胃癌治疗新靶点
Lingling Huang,Tingting Tan,Yingyu Mao et al.
Lingling Huang et al.
Gastric cancer (GC) is still the biggest factor in cancer-related death worldwide, and existing therapies have low therapeutic effectiveness. A possible cancer treatment target is ferroptosis, an iron-dependent kind of lipid peroxidation-in...
Pediatric sequential organ failure assessment score predicts prognosis in children with acute lymphoblastic leukemia and sepsis: association with early multiple organ dysfunction [0.03%]
儿科序贯性脏器功能衰竭评分可预测急性淋巴细胞白血病合并感染患儿预后：与早期多器官功能障碍的关系
Zhongwei Yin,Chengqi Shen,Yulin Chen et al.
Zhongwei Yin et al.
Objective: To systematically analyze the clinical characteristics and prognostic factors of children with acute lymphoblastic leukemia (ALL) complicated by sepsis, and to compare the predictive efficacy of different scori...
SP1-IKBIP axis promotes the proliferation and invasion of glioma with Wnt/β-catenin associated epithelial-mesenchymal transition [0.03%]
SP1-IKBIP轴通过Wnt/β-连环蛋白相关上皮间质转化促进胶质瘤的增殖和侵袭
Nan Liu,Mingyue Zhao,Lei Xu et al.
Nan Liu et al.
Glioma is the most aggressive tumor of the central nervous system and is associated with poor prognosis, especially in patients with high-grade gliomas. In this study, we investigated the biological role of inhibitor of kappa B kinase inter...
Rare NUP98::SETBP1 fusion transcript in a refractory adult T-cell lymphoblastic lymphoma [0.03%]
成人T细胞淋巴母细胞淋巴瘤中罕见的NUP98-SETBP1融合转录本
Xiaoyong Chen,Linlin Wang,Junyan Zou et al.
Xiaoyong Chen et al.
T-lymphoblastic lymphoma (T-LBL) is an aggressive malignancy of T-lymphoid precursors, rarely co-occurring with consequent rearrangement of nucleoporin 98 (NUP98) gene. The NUP98::SETBP1 fusion gene was first reported in a de novo T-cell ac...
Analysis of influencing factors of recurrence after thoracoscopic resection in patients with Stage I a lung adenocarcinoma [0.03%]
电视胸腔镜手术治疗IA期肺腺癌术后复发的危险因素分析
Rui-Shi Wei,Jie Ma,Xin-Hua Li et al.
Rui-Shi Wei et al.
This study aimed to investigate the influencing factors of recurrence after thoracoscopic resection in patients with Stage I a lung adenocarcinoma. The derivation cohort consisted of 104 patients admitted between February 2020 and December ...