Unveiling the prognostic implications of RPLP1 upregulation in osteosarcoma [0.03%]
RPLP1上调在骨肉瘤预后中的作用及机制研究
Xinhui Du,Hua Wei,Boya Zhang et al.
Xinhui Du et al.
Osteosarcoma, a malignant bone tumor characterized by a high rate of metastasis and poor survival, presents a critical need for identifying novel biomarkers associated with metastasis. In this study, we conducted an extensive analysis utili...
IL25+ macrophages are a key determinant of treatment resistance of IL17RB+ breast cancer [0.03%]
IL25阳性巨噬细胞是IL17RB阳性乳腺癌治疗抵抗的关键决定因素
Yukinori Ozaki,Keiichi Kinowaki,Hidetaka Kawabata et al.
Yukinori Ozaki et al.
Recurrence and metastasis are resistant to multimodal treatments, and are the major causes of death in breast cancer. Accumulating evidence suggests that the IL17RB signaling pathway plays a key role in progression and metastasis of breast ...
Simultaneous inhibition of discoidin domain receptor 1 and integrin αVβ3 radiosensitizes human glioblastoma cells [0.03%]
Discoidin域受体1和整合素αVβ3的同时抑制可增强对人类胶质母细胞瘤细胞的放射增敏作用
Marc Elser,Anne Vehlow,Tareq A Juratli et al.
Marc Elser et al.
Glioblastomas (GBM) are the most common primary brain tumors in adults and associated with poor clinical outcomes due to therapy resistances and destructive growth. Interactions of cancer cells with the extracellular matrix (ECM) play a piv...
Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers [0.03%]
开发基于三唑的PKC抑制剂以克服EGFR突变型肺癌中对EGFR抑制剂的耐药性
Pei-Chih Lee,Vathan Kumar,Govindan Sivakumar et al.
Pei-Chih Lee et al.
Protein kinase C delta (PKCδ) is prominently expressed in the nuclei of EGFR-mutant lung cancer cells, and its presence correlates with poor survival of the patients undergoing EGFR inhibitor treatment. The inhibition of PKCδ has emerged ...
GALNT5 functions as a suppressor of ferroptosis and a predictor of poor prognosis in pancreatic adenocarcinoma [0.03%]
GALNT5作为铁死亡抑制因子及预后不良标志物在胰腺癌中的功能研究
Jiayi Yan,Haiyi Gong,Shuai Han et al.
Jiayi Yan et al.
Mucin-type O-glycosylation, a posttranslational modification of membrane and secretory proteins, facilitates metastasis and immune escape in tumor cells. N-acetylgalactosaminyl-transferase 5 (GALNT5), the enzyme initiating mucin-type O-glyc...
Synergistic effect of TTF and 5-FU combination treatment on pancreatic cancer cells [0.03%]
TTF与5-FU联合治疗对胰腺癌细胞的协同作用
Yunhui Jo,Eunjun Lee,Geon Oh et al.
Yunhui Jo et al.
The present study investigated the therapeutic potential of combining tumor-treating fields (TTF), a novel cancer treatment modality that employs low-intensity, alternating electric fields, with 5-fluorouracil (5-FU), a standard chemotherap...
Inhibition of Na+/H+ exchanger (NHE) 7 by 5-(N-ethyl-N-isopropyl)-Amiloride displays anti-cancer activity in non-small cell lung cancer by disrupting cancer stem cell activity and downregulating PD-L1 expression [0.03%]
5-（N乙基-N异丙基）胺利酮通过抑制Na+/H+交换器（NHE）7在非小细胞肺癌中显示抗肿瘤活性，该过程可扰乱癌症干细胞活性并降低PD-L1表达水平
Bing-Yen Wang,Huan-Ting Shen,Yu-Ling Lee et al.
Bing-Yen Wang et al.
The alkaline intracellular environment of cancer cells is critical for cell proliferation and controlled by various plasma membrane transporters including Na+/H+ exchangers (NHEs). NHEs can also mediate cell behavior by regulating signaling...
Sulforaphene suppresses oesophageal cancer growth through mitogen- and stress-activated kinase 2 in a PDX mouse model [0.03%]
通过原代人源肿瘤移植小鼠模型筛选的 broccoli化合物硫化物抑制食管癌增殖的新靶点MAPK14
Chengjuan Zhang,Qiong Wu,Ke Yao et al.
Chengjuan Zhang et al.
Background: Although sulforaphene has potential anticancer effects, little is known about its effect on oesophageal squamous cell carcinoma (ESCC) invasiveness. ...
CYR61 promotes colorectal carcinoma progression via activating epithelial-mesenchymal transition [0.03%]
Cyr61通过激活上皮间质转化促进结直肠癌进展
Shelan Rasool,Qais Al Ismaeel,Sardar H Arif
Shelan Rasool
Colorectal carcinoma is the third most common type of cancer. Although the role of matricellular proteins and their association with tumor progression is well documented, limited data are available concerning their involvement in colorectal...
Detection of clinically important BRCA gene mutations in ovarian cancer patients using next generation sequencing analysis [0.03%]
应用高通量测序技术对卵巢癌患者进行重要乳腺癌易感基因突变的检测分析研究
Yiping Zhang,Akbar Ali,Jun Xie
Yiping Zhang
Ovarian cancer, a complex and aggressive malignancy, remains a significant challenge in clinical oncology due to its heterogeneous nature and limited therapeutic options. In this study, across Pakistani ovarian cancer patients, we conducted...