Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway [0.03%]
来自Tirandamycin生物合成途径的多功能P450单加氧酶TamI迭代C-H氧化的分子机制
Sean A Newmister,Kinshuk Raj Srivastava,Rosa V Espinoza et al.
Sean A Newmister et al.
Biocatalysis offers an expanding and powerful strategy to construct and diversify complex molecules by C─H bond functionalization. Due to their high selectivity, enzymes have become an essential tool for C─H bond functionalization and off...
Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics [0.03%]
从头开始的分子动力学揭示了CRISPR-Cas9非目标DNA切割的催化机制
Lorenzo Casalino,Łukasz Nierzwicki,Martin Jinek et al.
Lorenzo Casalino et al.
CRISPR-Cas9 is a cutting-edge genome editing technology, which uses the endonuclease Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is promising to treat a myriad of human genetic diseases. Nevertheless,...
Engineer P. multocida Heparosan Synthase 2 (PmHS2) for Size-Controlled Synthesis of Longer Heparosan Oligosaccharides [0.03%]
工程化多杀巴斯德菌肝素硫酸酯 synthase 2（PmHS2）以可控合成较长的氨基己糖寡糖
Lan Na,Hai Yu,John B McArthur et al.
Lan Na et al.
Pasteurella multocida heparosan synthase 2 (PmHS2) is a dual-function polysaccharide synthase having both α1-4-N-acetylglucosaminyltransferase (α1-4-GlcNAcT) and β1-4-glucuronyltransferase (β1-4-GlcAT) activities located in two separate...
Crystallographic Characterization of the Carbonylated A-Cluster in Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase [0.03%]
一氧化碳脱氢酶/乙酰辅酶A合成酶的羰基化A簇的晶体学表征
Steven E Cohen,Mehmet Can,Elizabeth C Wittenborn et al.
Steven E Cohen et al.
The Wood-Ljungdahl pathway allows for autotrophic bacterial growth on carbon dioxide, with the last step in acetyl-CoA synthesis catalyzed by the bifunctional enzyme carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS). ACS uses a c...
Effect of the Morphology of the High-Surface-Area Support on the Performance of the Oxygen-Evolution Reaction for Iridium Nanoparticles [0.03%]
载体的形态对铱纳米颗粒氧析出反应性能的影响
Leonard Moriau,Marjan Bele,Živa Marinko et al.
Leonard Moriau et al.
The development of affordable, low-iridium-loading, scalable, active, and stable catalysts for the oxygen-evolution reaction (OER) is a requirement for the commercialization of proton-exchange membrane water electrolyzers (PEMWEs). However,...
Chimeric Cellobiose Dehydrogenases Reveal the Function of Cytochrome Domain Mobility for the Electron Transfer to Lytic Polysaccharide Monooxygenase [0.03%]
嵌合型纤维二糖脱氢酶揭示了细胞色素结构域的运动对向裂解多糖单加氧酶电子传递的功能作用
Alfons K G Felice,Christian Schuster,Alan Kadek et al.
Alfons K G Felice et al.
The natural function of cellobiose dehydrogenase (CDH) to donate electrons from its catalytic flavodehydrogenase (DH) domain via its cytochrome (CYT) domain to lytic polysaccharide monooxygenase (LPMO) is an example of a highly efficient ex...
Expanding the chemical space of synthetic cyclic peptides using a promiscuous macrocyclase from prenylagaramide biosynthesis [0.03%]
利用牻牛儿酰加拉霉胺生物合成中的泛底物环化酶扩展合成环肽的化学空间
Snigdha Sarkar,Wenjia Gu,Eric W Schmidt
Snigdha Sarkar
Cyclic peptides are excellent drug candidates, placing macrocyclization reactions at the apex of drug development. PatG and related dual-action proteases from cyanobactin biosynthesis are responsible for cleaving off the C-terminal recognit...
Interplay between CO Disproportionation and Oxidation: On the Origin of the CO Reaction Onset on Atomic Layer Deposition-Grown Pt/ZrO2 Model Catalysts [0.03%]
CO disproportionation与氧化之间的相互作用：关于原子层沉积生长的Pt / ZrO2模型催化剂上CO反应起始的研究
Verena Pramhaas,Matteo Roiaz,Noemi Bosio et al.
Verena Pramhaas et al.
Pt/ZrO2 model catalysts were prepared by atomic layer deposition (ALD) and examined at mbar pressure by operando sum frequency generation (SFG) spectroscopy and near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) combined with ...
Steering the Methane Dry Reforming Reactivity of Ni/La2O3 Catalysts by Controlled In Situ Decomposition of Doped La2NiO4 Precursor Structures [0.03%]
通过原位控制掺杂La2NiO4前驱体结构的分解来调控Ni/La2O3催化剂的甲烷干重整反应性
Maged F Bekheet,Parastoo Delir Kheyrollahi Nezhad,Nicolas Bonmassar et al.
Maged F Bekheet et al.
The influence of A- and/or B-site doping of Ruddlesden-Popper perovskite materials on the crystal structure, stability, and dry reforming of methane (DRM) reactivity of specific A2BO4 phases (A = La, Ba; B = Cu, Ni) has been evaluated by a ...
Size-Controlled Chemoenzymatic Synthesis of Homogeneous Oligosaccharides of Neisseria meningitidis W Capsular Polysaccharide [0.03%]
化学生物学方法控制脑膜炎奈瑟氏球菌W型荚膜多糖均一寡糖聚合度的合成
Riyao Li,Hai Yu,Saddam M Muthana et al.
Riyao Li et al.
Neisseria meningitidis (Nm) serogroup W (NmW) is one of the six meningococcal serogroups that cause majority of invasive meningococcal diseases (IMD). Its capsular polysaccharide (CPS) is a virulence factor and is a key component in NmW CPS...