Diastereo- and Enantioselective CuH-Catalyzed Hydroamination of Strained Trisubstituted Alkenes [0.03%]
应化学选择性和对映选择性的铜催化的环张力三取代烯烃的氢氨化反应
Sheng Feng,Hua Hao,Peng Liu et al.
Sheng Feng et al.
Amine-substituted cyclobutanes and cyclopropanes are important substructures in biologically active compounds. Moreover, many of the cycloalkane units bear multiple substituents and stereocenters. Therefore, synthetic methods that produce p...
Spatial Profiling of a Pd/Al2O3 Catalyst during Selective Ammonia Oxidation [0.03%]
用于选择性氨氧化的Pd/Al2O3催化剂的空间分布 профилирование пространственного расположения катализатора Pd/Al2O3 при селективном окислении аммиака
Donato Decarolis,Adam H Clark,Tommaso Pellegrinelli et al.
Donato Decarolis et al.
The utilization of operando spectroscopy has allowed us to watch the dynamic nature of supported metal nanoparticles. However, the realization that subtle changes to environmental conditions affect the form of the catalyst necessitates that...
Shedding Light on CO Oxidation Surface Chemistry on Single Pt Catalyst Nanoparticles Inside a Nanofluidic Model Pore [0.03%]
单个Pt催化剂纳米颗粒在纳流通道模型孔道中CO氧化表面化学性质的研究
David Albinsson,Stephan Bartling,Sara Nilsson et al.
David Albinsson et al.
Investigating a catalyst under relevant application conditions is experimentally challenging and parameters like reaction conditions in terms of temperature, pressure, and reactant mixing ratios, as well as catalyst design, may significantl...
A Widely Applicable Dual Catalytic System for Cross-Electrophile Coupling Enabled by Mechanistic Studies [0.03%]
机理研究指导下实现的交叉偶联反应广泛适用性双催化体系
David J Charboneau,Emily L Barth,Nilay Hazari et al.
David J Charboneau et al.
A dual catalytic system for cross-electrophile coupling reactions between aryl halides and alkyl halides that features a Ni catalyst, a Co cocatalyst, and a mild homogeneous reductant is described. Mechanistic studies indicate that the Ni c...
Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach [0.03%]
通过催化自由基H/D交换法实现醛基的氘代
Yueteng Zhang,Peng Ji,Yue Dong et al.
Yueteng Zhang et al.
H/D exchange at formyl groups represents the straightforward approach to C-1 deuterated aldehydes. This transformation has been recently realized by transition metal and NHC carbene catalysis. Mechanistically, all these processes involve an...
Rapid, Biomimetic Degradation of a Nerve Agent Simulant by Incorporating Imidazole Bases into a Metal-Organic Framework [0.03%]
通过将咪唑基引入金属有机框架中实现神经毒剂模拟物的快速生物降解
Hong-Bin Luo,Anthony J Castro,Megan C Wasson et al.
Hong-Bin Luo et al.
Metal-organic frameworks (MOFs) are excellent catalytic materials for the hydrolytic degradation of nerve agents and their simulants. However, most of the MOF-based hydrolysis catalysts to date are reliant on liquid water media buffered by ...
Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis [0.03%]
重构内切醇合酶催化作用中的分子动态以防止羟基化反应发生
Prabhakar L Srivastava,Andrés M Escorcia,Florence Huynh et al.
Prabhakar L Srivastava et al.
Natural sesquiterpene synthases have evolved to make complex terpenoids by quenching reactive carbocations either by proton transfer or by hydroxylation (water capture), depending on their active site. Germacradien-11-ol synthase (Gd11olS) ...
The Impact of Water on Ru-Catalyzed Olefin Metathesis: Potent Deactivating Effects Even at Low Water Concentrations [0.03%]
水对钌催化 olefin metathesis反应的影响：即使在低浓度下也有很强的失活作用
Christian O Blanco,Joshua Sims,Daniel L Nascimento et al.
Christian O Blanco et al.
Ruthenium catalysts for olefin metathesis are widely viewed as water-tolerant. Evidence is presented, however, that even low concentrations of water cause catalyst decomposition, severely degrading yields. Of 11 catalysts studied, fast-init...
Potassium Trimethylsilanolate Enables Rapid, Homogeneous Suzuki-Miyaura Cross-Coupling of Boronic Esters [0.03%]
全新的均匀的 Suzuki-Miyaura 反应：用于硼酸酯交叉偶联反应的超强钾基催化剂钾三甲基硅醇盐的优点
Connor P Delaney,Vincent M Kassel,Scott E Denmark
Connor P Delaney
Herein, a mild and operationally simple method for the Suzuki-Miyaura cross-coupling of boronic esters is described. Central to this advance is the use of the organic-soluble base, potassium trimethylsilanolate, which allows for a homogeneo...
C─C Cleavage Approach to C─H Functionalization of Saturated Aza-Cycles [0.03%]
通过碳碳键断裂实现饱和氮杂环化合物的碳氢官能团化反应
Jose B Roque,Yusuke Kuroda,Justin Jurczyk et al.
Jose B Roque et al.
Saturated cyclic amines (aza-cycles) are ubiquitous structural motifs found in pharmaceuticals, agrochemicals, and bioactive natural products. Given their importance, methods that directly functionalize aza-cycles are in high demand. Herein...