Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device [0.03%]
用于聚类培养的组合式锥形模板(TASCL)装置构建的三维体外肝组织
Yoshitaka Miyamoto,Masashi Ikeuchi,Hirofumi Noguchi et al.
Yoshitaka Miyamoto et al.
Attempts to create artificial liver tissue from various cells have been reported as an alternative method for liver transplantation and pharmaceutical testing. In the construction of artificial liver tissue, the selection of the cell source...
Improvement of Infusion Process in Cell Transplantation: Effect of Shear Stress on Hepatocyte Viability Under Horizontal and Vertical Syringe Orientation [0.03%]
细胞移植灌注过程的改进：水平和垂直注射器方位对肝细胞存活率的影响研究
Sandi Sufiandi,Hiromichi Obara,Shin Enosawa et al.
Sandi Sufiandi et al.
Improving cell viability and function are important for enhancing the clinical results of cell transplantation. The relationship between cell viability and shear stress remains unexplained, and sedimentation effects during the infusion proc...
Synergistic Effects of Calcineurin Inhibitors and Steroids on Steroid Sensitivity of Peripheral Blood Mononuclear Cells [0.03%]
钙调神经磷酸酶抑制剂和糖皮质激素对外周血单个核细胞糖皮质激素敏感性协同影响的初步研究
Hironori Takeuchi,Hitoshi Iwamoto,Yuki Nakamura et al.
Hironori Takeuchi et al.
The steroid receptor (SR) complex contains FKBP51 and FKBP52, which bind to tacrolimus (TAC) and cyclophilin 40, which, in turn, bind to cyclosporine (CYA); these influence the intranuclear mobility of steroid-SR complexes. Pharmacodynamic ...
Hirofumi Noguchi
Hirofumi Noguchi
Preculturing Islets With Adipose-Derived Mesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically Preferred Intraportal Site [0.03%]
预培养的移植物可以有效改善临床偏好的肝内移植效率
Chloe L Rackham,Paramjeet K Dhadda,Aurélie M Le Lay et al.
Chloe L Rackham et al.
We have recently shown that preculturing islets with kidney-derived mesenchymal stromal cells (MSCs) improves transplantation outcome in streptozotocin-diabetic mice implanted with a minimal mass of islets beneath the kidney capsule. In the...
Human Menstrual Blood-Derived Mesenchymal Cells as New Human Feeder Layer System for Human Embryonic Stem Cells [0.03%]
人经血源间充质细胞作为人胚胎干细胞的新 feeder 细胞系统
Danúbia Silva Dos Santos,Vanessa Carvalho Coelho de Oliveira,Karina Dutra Asensi et al.
Danúbia Silva Dos Santos et al.
Human embryonic stem cells (hESCs) in general require coculture with feeder layers in order to remain undifferentiated. However, the use of animal-derived feeder layers is incompatible with the clinical setting. The objective of this work w...
Integration-Free Human Induced Pluripotent Stem Cells From Type 1 Diabetes Patient Skin Fibroblasts Show Increased Abundance of Pancreas-Specific microRNAs [0.03%]
来自1型糖尿病病人皮肤纤维母细胞的无整合人类诱导多能干细胞显示有更高丰度的胰腺特异性的microRNA
Jun Liu,Mugdha V Joglekar,Huseyin Sumer et al.
Jun Liu et al.
Type 1 diabetes (T1D) is a disease that is typically associated with multigenetic changes as well as environmental triggers. Disease-specific induced pluripotent stem cells (iPSCs) are preferable cell sources to study T1D, as they are deriv...
Yue Yu,Xuehao Wang,Scott L Nyberg
Yue Yu
Tens of millions of patients are affected by liver disease worldwide. Many of these patients can benefit from therapy involving hepatocyte transplantation. Liver transplantation is presently the only proven treatment for many medically refr...
David J Eve
David J Eve
A wide diversity of subjects are presented at the annual American Society of Neural Therapy and Repair meeting every year, and 2013 was no exception. An insight into the current research trends in regenerative medicine was provided, includi...
Autologous Skeletal Myoblast Sheet Therapy for Porcine Myocardial Infarction Without Increasing Risk of Arrhythmia [0.03%]
自体骨骼肌前体细胞治疗猪心肌梗死而不增加心律失常风险
Yutaka Terajima,Tatsuya Shimizu,Shinpei Tsuruyama et al.
Yutaka Terajima et al.
Safety concerns of ventricular tachyarrhythmia have arisen from some clinical trials of autologous skeletal myoblast (SkM) injection therapy. This study examined the effect and safety of SkM sheet therapy in a pig model of chronic myocardia...