Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling [0.03%]
鸟苷酸交换因子活化Rab8a参与 toll 样受体信号转导
Samuel J Tong,Adam A Wall,Yu Hung et al.
Samuel J Tong et al.
Macrophages are important immune sentinels that detect and clear pathogens and initiate inflammatory responses through the activation of surface receptors, including Toll-like receptors (TLRs). Activated TLRs employ complex cellular traffic...
The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108 [0.03%]
CDC42效应蛋白MRCKβ在苏氨酸1108位点进行自磷酸化
Mathieu Unbekandt,Sergio Lilla,Sara Zanivan et al.
Mathieu Unbekandt et al.
The CDC42 small GTPase is a major influence on actin-myosin cytoskeleton organization and dynamics, signalling via effector proteins including the Myotonic dystrophy related CDC42-binding protein kinases (MRCK) α and β. We previously iden...
Effects of RhoA and RhoC upon the sensitivity of prostate cancer cells to glutamine deprivation [0.03%]
RhoA和RhoC对前列腺癌细胞谷氨酰胺剥夺敏感性的影响
Luciana Bueno De Paiva,Vanessa Aline Bernusso,João Agostinho Machado-Neto et al.
Luciana Bueno De Paiva et al.
RhoA and RhoC contribute to the regulation of glutamine metabolism, which is a crucial determinant of cell growth in some types of cancer. Here we investigated the participation of RhoA and RhoC in the response of prostate cancer cells to g...
Regulation of RhoA activation and cell motility by c-Jun N-terminal kinases and Net1 [0.03%]
c-Jun氨基末端激酶和Net1对RhoA活化及细胞运动的调节作用
Arzu Ulu,Jeffrey A Frost
Arzu Ulu
Jnks are mitogen activated protein kinases that are best known for regulating transcription and apoptotic signaling. However, they also play important roles in controlling cell motility and invasion by phosphorylating many actin and microtu...
Rab GTPases take centre stage in understanding Entamoeba histolytica biology [0.03%]
Rab GTPase在溶组织内阿米巴生物学研究中占主导地位
Kuldeep Verma,Vijay Kumar Srivastava,Sunando Datta
Kuldeep Verma
Rab GTPases constitute the largest subgroup in the Ras superfamily of GTPases. It is well established that different Rab GTPases are localized in discrete subcellular localization and regulate the membrane trafficking in nearly all eukaryot...
Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins [0.03%]
通过膜周边固定蛋白提高光调节GTP酶的空间分辨率
Orry Van Geel,Roland Hartsuiker,Theodorus W J Gadella
Orry Van Geel
Light-induced dimerizing systems, e.g. iLID, are an increasingly utilized optogenetics tool to perturb cellular signaling. The major benefit of this technique is that it allows external spatiotemporal control over protein localization with ...
The Rab7 subfamily across Paramecium aurelia species; evidence of high conservation in sequence and function [0.03%]
帕米尤蒙种类的Rab7亚家族；序列和功能高度保守的证据
Lydia J Bright,Michael Lynch
Lydia J Bright
We examined sequence conservation and signatures of selection in Rab7 proteins across 11 Paramecium aurelia species, and determined the localization patterns of two P. tetraurelia Rab7 paralogs when expressed as GFP fusions in live cells. W...
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis [0.03%]
RAS小G蛋白在多发性硬化症中的作用机制研究
Samantha Messina
Samantha Messina
Ras: signaling is involved in the development of autoimmunity in general. Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. It is widely recognized that a reduction of Foxp3+ r...
A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions [0.03%]
在间充质表型向上皮表型转化过程中同时调控Rac和Rho信号周期的GEF和GAP候选分子
Christopher P Toret,Andre Le Bivic
Christopher P Toret
The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP were...
Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae [0.03%]
抗癌化合物MBQ-167通过靶向芽殖酵母S.cerevisiae中的Cdc42抑制细胞极性和生长
Michael John Rivera-Robles,Julia Medina-Velázquez,Gabriela M Asencio-Torres et al.
Michael John Rivera-Robles et al.
The Rho GTPase Cdc42 is highly conserved in structure and function. Mechanical or chemical cues in the microenvironment stimulate the localized activation of Cdc42 to rearrange the actin cytoskeleton and establish cell polarity. A role for ...