Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells [0.03%]
T细胞中的Ras超家族小G蛋白与糖原磷酸化酶调节之间的关系研究
Francisco Llavero,Alazne Arrazola Sastre,Miriam Luque Montoro et al.
Francisco Llavero et al.
Small GTPases, together with their regulatory and effector molecules, are key intermediaries in the complex signalling pathways that control almost all cellular processes, working as molecular switches to transduce extracellular cues into c...
Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells [0.03%]
识别增加初级人类内皮细胞中Cdc42活性的鸟苷核苷酸交换因子
Nathalie R Reinhard,Sanne Van Der Niet,Anna Chertkova et al.
Nathalie R Reinhard et al.
The Rho GTPase family is involved in actin dynamics and regulates the barrier function of the endothelium. One of the main barrier-promoting Rho GTPases is Cdc42, also known as cell division control protein 42 homolog. Currently, regulation...
RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding [0.03%]
RhoG和Cdc42可以通过WAVE调节复合物结合促进Rac依赖的梳状伪足形成
Matthias Schaks,Hermann Döring,Frieda Kage et al.
Matthias Schaks et al.
Cell migration frequently involves the formation of lamellipodial protrusions, the initiation of which requires Rac GTPases signalling to heteropentameric WAVE regulatory complex (WRC). While Rac-related RhoG and Cdc42 can potently stimulat...
Alemayehu A Gorfe,Kwang-Jin Cho
Alemayehu A Gorfe
Activating somatic K-Ras mutations are associated with >15% all human tumors and up to 90% of specific tumor types such as pancreatic cancer. Successfully inhibiting abnormal K-Ras signaling would therefore be a game changer in cancer thera...
Paradoxical regulation of glucose-induced Rac1 activation and insulin secretion by RhoGDIβ in pancreatic β-cells [0.03%]
RhoGDIβ通过矛盾调节葡萄糖诱导的胰岛β细胞内Rac1活化和胰岛素分泌
Vijayalakshmi Thamilselvan,Anjaneyulu Kowluru
Vijayalakshmi Thamilselvan
Small GTPases (e.g., Rac1) play key roles in glucose-stimulated insulin secretion (GSIS) in the β-cell. We investigated regulation by RhoGDIβ of glucose-induced activation of Rac1 and insulin secretion. RhoGDIβ is expressed in INS-1 832/...
Dusanka Deretic,Esben Lorentzen,Theresa Fresquez
Dusanka Deretic
The small GTPase Arf4-based ciliary membrane-targeting complex recognizes specific targeting signals within sensory receptors and regulates their directed movement to primary cilia. Activated Arf4 directly binds the VxPx ciliary-targeting s...
Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells [0.03%]
在RAS突变的癌细胞中，锚定非依赖性生长条件揭示了转化和生存对SOS2的不同的依赖性
Erin Sheffels,Nancy E Sealover,Patricia L Theard et al.
Erin Sheffels et al.
The RAS family of genes (HRAS, NRAS, and KRAS) is mutated in around 30% of human tumours. Wild-type RAS isoforms play an important role in mutant RAS-driven oncogenesis, indicating that RasGEFs may play a significant role in mutant RAS-driv...
The UIG-1/CDC-42 guanine nucleotide exchange factor acts in parallel to CED-10/Rac1 during axon outgrowth in Caenorhabditis elegans [0.03%]
UIG-1/CDC-42鸟苷酸交换因子可平行于CED-10/Rac1在秀丽隐杆线虫轴突生长过程中发挥功能
Wei Cao,Shuer Deng,Roger Pocock
Wei Cao
During development of the brain, neuronal circuits are formed through the projection of axons and dendrites in response to guidance signals. Rho GTPases (Rac1/RhoA/Cdc42) are major regulators of axo-dendritic outgrowth and guidance due to t...
Ian Aj Lorimer
Ian Aj Lorimer
Glioblastoma is an aggressive and incurable form of brain cancer. Both mutation analysis in human glioblastoma and mouse modelling studies have shown that aberrant activation of the PI 3-kinase pathway is a central driver of glioblastoma ma...
Hanh My Hoang,Hope Gloria Umutesi,Jongyun Heo
Hanh My Hoang
Son of Sevenless (SOS), one of guanine nucleotide exchange factors (GEFs), activates Ras. We discovered that the allosteric domain of SOS yields SOS to proceed a previously unrecognized autoactivation kinetics. Its essential feature is a ti...