Sara Basbous,Roberta Azzarelli,Emilie Pacary et al.
Sara Basbous et al.
Rnd proteins constitute a subfamily of Rho GTPases represented in mammals by Rnd1, Rnd2 and Rnd3. Despite their GTPase structure, their specific feature is the inability to hydrolyse GTP-bound nucleotide. This aspect makes them atypical amo...
Exploring a role for fatty acid synthase in prostate cancer cell migration [0.03%]
探索脂肪酸合酶在前列腺癌细胞迁移中的作用
Mario De Piano,Valeria Manuelli,Giorgia Zadra et al.
Mario De Piano et al.
Fatty acid synthase (FASN) is commonly overexpressed in prostate cancer and associated with tumour progression. FASN is responsible for de novo synthesis of the fatty acid palmitate; the building block for protein palmitoylation. A function...
New insights into RhoA/Rho-kinase signaling: a key regulator of vascular contraction [0.03%]
RhoA/Rho激酶信号传导的新见解：血管收缩的关键调节因子
Kenia Pedrosa Nunes,R Clinton Webb
Kenia Pedrosa Nunes
While Rho-signalling controlling vascular contraction is a canonical mechanism, with the modern approaches used in research, we are advancing our understanding and details into this pathway are often uncovered. RhoA-mediated Rho-kinase is t...
Margaritha M Mysior,Jeremy C Simpson
Margaritha M Mysior
Rho GTPases are known to play an essential role in fundamental processes such as defining cell shape, polarity and migration. As such, the majority of Rho GTPases localize and function at, or close to, the plasma membrane. However, it is be...
Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction [0.03%]
GTP和Rho GTPase在胰岛β细胞功能及其失调中的作用
Anjaneyulu Kowluru
Anjaneyulu Kowluru
A growing body of evidence implicates requisite roles for GTP and its binding proteins (Rho GTPases) in the cascade of events leading to physiological insulin secretion from the islet beta cell. Interestingly, chronic exposure of these cell...
A functional antagonism between RhoJ and Cdc42 regulates fibronectin remodelling during angiogenesis [0.03%]
RhoJ和Cdc42之间的功能拮抗作用调节血管生成过程中纤连蛋白的重塑
Ananthalakshmy Sundararaman,Harry Mellor
Ananthalakshmy Sundararaman
Angiogenesis is the formation of new blood vessels from pre-existing ones. Angiogenesis requires endothelial cells to change shape and polarity, as well as acquire the ability to directionally migrate ‒ processes that are classically regul...
A regulatory role of membrane by direct modulation of the catalytic kinase domain [0.03%]
膜通过直接调节催化激酶结构域发挥的调控作用
Priyanka Prakash
Priyanka Prakash
Cell membrane modulates the function and activity of specific proteins and acts more than just a non-specific scaffolding machinery. In this review, I focus on studies that highlight a direct membrane-mediated modulation of the catalytic ki...
Selection of established tumour cells through narrow diameter micropores enriches for elevated Ras/Raf/MEK/ERK MAPK signalling and enhanced tumour growth [0.03%]
通过狭窄直径微孔选择富集 Established肿瘤细胞 可提高Ras/Raf/MEK/ERK MAPK信号转导并增强肿瘤生长
Dominika A Rudzka,Susan Mason,Matthew Neilson et al.
Dominika A Rudzka et al.
As normal cells become cancer cells, and progress towards malignancy, they become progressively softer. Advantages of this change are that tumour cells become more deformable, and better able to move through narrow constraints. We designed ...
Isabella R Blum,Caroline Behling-Hess,Marco Padilla-Rodriguez et al.
Isabella R Blum et al.
Membrane trafficking establishes and maintains epithelial polarity. Rab22a has a polarized distribution in activated T-cells, but its role in epithelial polarity has not been investigated. We showed previously that Rab14 acts upstream of Ar...
Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast [0.03%]
Cdc42促进Bgs1募集以进行细胞分裂中期隔合成和葡聚糖酶定位以进行分隔酵母细胞分离
Udo N Onwubiko,Julie Rich-Robinson,Rose Albu Mustaf et al.
Udo N Onwubiko et al.
Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum synthesis followed by septum digestion resulting in cell separation. A recent report indicates that endocytosis is required for septum synthesis and cel...