BRAG1/IQSEC2 as a regulator of small GTPase-dependent trafficking [0.03%]
BRAG1/IQSEC2在小G蛋白依赖的膜转运中的调控作用
Amber Petersen,Joshua C Brown,Nashaat Z Gerges
Amber Petersen
Precise trafficking events, such as those that underlie synaptic transmission and plasticity, require complex regulation. G-protein signaling plays an essential role in the regulation of membrane and protein trafficking. However, it is not ...
Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera [0.03%]
rho鸟苷酸交换因子在癌症中并非如此糟糕
Javier Robles-Valero,L Francisco Lorenzo-Martín,Isabel Fernández-Pisonero et al.
Javier Robles-Valero et al.
Rho GDP/GTP exchange factors (GEFs), the enzymes that trigger the stimulation of Rho GTPases during cell signaling, are widely deemed as potential therapeutic targets owing to their protumorigenic functions. However, the sparse use of anima...
Shared mechanisms regulate spatiotemporal RhoA-dependent actomyosin contractility during adhesion and cell division [0.03%]
共同机制调节粘附和细胞分裂过程中RhoA依赖的时空肌动蛋白-肌球蛋白收缩性
Patrick W B Derksen,Robert A H van de Ven
Patrick W B Derksen
Local modulation of the actin cytoskeleton is essential for the initiation and maintenance of strong homotypic adhesive interfaces between neighboring cells. The epithelial adherens junction (AJ) fulfils a central role in this process by me...
Ral function in muscle is required for flight maintenance in Drosophila [0.03%]
甲壳素合成酶Ral在肌肉中的功能是果蝇持续飞行所必需的
Shlesha Richhariya,Gaiti Hasan
Shlesha Richhariya
Ral is a small GTPase of the Ras superfamily that is important for a number of cellular functions. Recently, we found that expression of Ral is regulated by store-operated calcium entry (SOCE) in Drosophila neurons. In this study, through g...
Expression of a T39N mutant Rab32 protein arrests mitochondria movement within neurites of differentiated SH-SY5Y cells [0.03%]
T39N突变Rab32蛋白表达可使神经颗粒内线粒体运动停滞
Jonas Rybnicek,Samira Samtleben,Maria Sol Herrera-Cruz et al.
Jonas Rybnicek et al.
We have shown that multiple sclerosis (MS) and endoplasmic reticulum (ER) stress induce Rab32, an ER/mitochondria-localized small GTPase. High levels of both dominant-active (Q85L) or dominant-inactive (T39N) Rab32 are toxic to neurons. Whi...
Small change, big effect: Taking RAS by the tail through suppression of post-prenylation carboxylmethylation [0.03%]
小改变大效果：通过抑制出芽后羧基甲基化抑制RAS
Hiu Yeung Lau,Mei Wang
Hiu Yeung Lau
Mutant RAS isoforms are the most common oncogenes affecting human cancers. After decades of effort in developing drugs targeting oncogenic RAS-driven cancers, we are still charting an unclear path. Despite recent developments exemplified by...
A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor [0.03%]
一个新的异戊二烯-多碱性氨基酸区编码决定了K-Ras膜锚的脂质结合特异性
Yong Zhou,John F Hancock
Yong Zhou
Ras proteins must localize to the plasma membrane (PM) for biological function. The membrane anchor of the K-Ras4B isoform comprises a farnesylated and methylated C-terminal cysteine together with an adjacent hexa-lysine polybasic domain (P...
Consequences of Rab GTPase dysfunction in genetic or acquired human diseases [0.03%]
Rab小G蛋白功能障碍在遗传或获得性疾病中的后果
Marcellus J Banworth,Guangpu Li
Marcellus J Banworth
Rab GTPases are important regulators of intracellular membrane trafficking in eukaryotes. Both activating and inactivating mutations in Rab genes have been identified and implicated in human diseases ranging from neurological disorders to c...
Eun-Kyoung Choi,Jae-Gyu Kim,Hee-Jun Kim et al.
Eun-Kyoung Choi et al.
Rho GTPases play significant roles in cellular function and their activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), providing activation and inactivation of these GTPases, respectivel...
Richard G Hodge,Anne J Ridley
Richard G Hodge
Rho GTPases play central roles in a wide variety of cellular processes, including cytoskeletal dynamics, cell adhesion and cell polarity. RhoU and RhoV are Rho GTPases that have some atypical properties compared with classical Rho family me...