Neeraj Badjatia,Christopher J White,Abbot Laptook et al.
Neeraj Badjatia et al.
Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke [0.03%]
轻度低体温可减少组织型纤溶酶原活化物相关性出血和血脑屏障破坏：实验研究
Xian Nan Tang,Liping Liu,Maya A Koike et al.
Xian Nan Tang et al.
Therapeutic hypothermia has shown neuroprotective promise, but whether it can be used to improve outcome in stroke has yet to be determined in patients. Recombinant tissue plasminogen activator (rt-PA) is only given to a minority of patient...
DNA microarray analysis of the mouse adrenal gland for the detection of hypothermia biomarkers: potential usefulness for forensic investigation [0.03%]
用于检测低温生物学标志物的小鼠肾上腺DNA微阵列分析在法医调查中的潜在应用价值研究
Masataka Takamiya,Kiyoshi Saigusa,Koji Dewa
Masataka Takamiya
We analyzed the adrenal gland transcriptome of mice killed by hypothermia using DNA microarray technology. A total of 4051 significantly expressed genes were identified; 2015 genes were upregulated and 2036 were downregulated.The FBJ osteos...
Determinants of pneumonia during endovascular hypothermia: editorial commentary on Lyden et al., 2013 [0.03%]
Lyden等,2013述评：血管内低温治疗时肺炎的发病因素
Helen M Bramlett
Helen M Bramlett
Patrick Lyden,Karin Ernstrom,Rema Raman
Patrick Lyden
Therapeutic hypothermia is a promising neuroprotective therapy with multiple mechanisms of action. Previously, we demonstrated the feasibility of thrombolysis combined with endovascular hypothermia and an antishivering regimen, but pneumoni...
Temporal profile of cerebrospinal fluid, plasma, and brain interleukin-6 after normothermic fluid-percussion brain injury: effect of secondary hypoxia [0.03%]
常压脑冲击伤后脑脊液、血浆及脑组织中白细胞介素-6的时程变化：二次低氧的影响
Katina Chatzipanteli,Elizabeth Vitarbo,Ofelia F Alonso et al.
Katina Chatzipanteli et al.
Interleukin-6 (IL-6) is a proinflammatory cytokine that may play multiple roles in the pathogenesis of traumatic brain injury (TBI). The present study determined time-dependent changes in IL-6 concentrations in vulnerable brain regions, cer...
Therapeutic hypothermia for refractory status epilepticus in a child with malignant migrating partial seizures of infancy and SCN1A mutation: a case report [0.03%]
婴儿严重局灶性癫痫持续状态伴SCN1A基因突变患儿的治疗性低温疗法：病例报告
Steven L Shein,Thomas Q Reynolds,Satyanarayana Gedela et al.
Steven L Shein et al.
Status epilepticus (SE) is a common indication for neurocritical care and can be refractory to standard measures. Refractory SE (RSE) is associated with high morbidity and mortality. Unconventional therapies may be utilized in certain cases...
Temperature affects thrombolytic efficacy using rt-PA and eptifibatide, an in vitro study [0.03%]
温度对rt-PA和Eptifibatide溶栓效果的影响-体外研究
Jason M Meunier,Wan-Tsu W Chang,Brent Bluett et al.
Jason M Meunier et al.
The potential for hypothermia as a neuroprotectant during stroke has led to its increase in clinical use. At the same time, combination pharmaceutical therapies for ischemic stroke using recombinant tissue plasminogen activator (rt-PA), and...
Post-cardiac arrest therapeutic hypothermia in New Jersey hospitals: analysis of adoption and implementation [0.03%]
新泽西州医院心脏停搏后复苏低温治疗的采用及实施分析
Derek DeLia,Henry E Wang,Jared Kutzin et al.
Derek DeLia et al.
Background: While national guidelines recommend the use of therapeutic hypothermia (TH) for the treatment of out-of-hospital cardiac arrest (OHCA), adoption of the technique has been slow. In addition, little is known abo...