Bilge Sözen Şahne,Elif Ulutaş Deniz,Onur Kabaş et al.
Bilge Sözen Şahne et al.
Objectives: Colleague solidarity, which emphasizes trust, independent thinking skills, and sharing, enables the problems encountered in the health service delivery to be dealt with effectively. This study aims to identify...
A Rapid, Precise, and Sensitive LC-MS/MS Method for the Quantitative Determination of Urinary Dopamine Levels via a Simple Liquid-liquid Extraction Technique [0.03%]
一种通过简单的液液萃取技术定量测定尿液多巴胺水平的快速、精确和灵敏的LC-MS/MS方法
Dilek Battal,Ayça Aktaş Süküroğlu,Fehmi Burak Alkaş et al.
Dilek Battal et al.
Objectives: Dopamine (DA) is a prominent biochemically complex neurotransmitter and immunomodulator. The quantification of DA could contribute to a better understanding of how endocrine system, cardiovascular and renal fu...
Minocycline Hydrochloride Controlled-release Microsphere Preparation Process Optimization Based on the Robust Design Method [0.03%]
基于稳健设计的盐酸米诺环素缓释微球制备工艺优化
Mohammad Karim Haidar,Fumiyoshi Yamashita,Mitsuru Hashida
Mohammad Karim Haidar
Objectives: The objective of the present study is to establish a robust preparation method that could steadily produce minocycline hydrochloride (MCH) microspheres regardless of used polymer types. ...
Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines [0.03%]
橄榄叶提取物对肝癌细胞系的遗传毒性和氧化应激作用的调查研究
Muhammed Yunus Bektay,Eray Metin Güler,Mustafa Gökçe et al.
Muhammed Yunus Bektay et al.
Objectives: Hepatocellular carcinoma (HCC) is the seventh most common cancer and the third leading cause of tumor-related deaths worldwide. Mechanisms underlying tumor onset, progression, and metastasis in the case of HCC...
Cocrystal Construction Between Rosuvastatin Calcium and L-asparagine with Enhanced Solubility and Dissolution Rate [0.03%]
与L-天冬酰胺共晶的罗苏伐他汀钙及其溶解性增强的性质研究
Venkata Deepthi Vemuri,Srinivas Lankalapalli
Venkata Deepthi Vemuri
Objectives: Rosuvastatin calcium (RSC) is a synthetic biopharmaceutical classification system class-II drug with a low solubility but high permeability. The drug is used in hyperlipidemia management. In this study, the ph...
Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs [0.03%]
大豆中的异黄酮作为日常营养素：作用机制及其对药物药代动力学的影响
Amelia Soyata,Aliya Nur Hasanah,Taofik Rusdiana
Amelia Soyata
Soybeans [Glycine max (L.)] are a good source of isoflavones. The main isoflavone components of soybean are daidzein, genistein, and glycitein. World soybean production is very high. Because of its pharmacological activity, soy isoflavone i...
The Antibacterial, Insecticidal and Nematocidal Activities and Toxicity Studies of Tanacetum falconeri Hook. f [0.03%]
费甩菊除虫活性及毒性研究
Muhammad Ismail,Atia Kowsar,Salma Javed et al.
Muhammad Ismail et al.
Objectives: Secondary bioactive metabolites from plants may be realistic alternatives to conventional synthetic chemicals. The aim of the present research was to test the Tanacetum falconeri Hook. f. in different bioassay...
In silico Modeling and Toxicity Profiling of a Set of Quinoline Derivatives as c-MET Inhibitors in the treatment of Human Tumors [0.03%]
一组喹啉衍生物作为c-MET抑制剂的计算机模拟和毒性评估及其在人类肿瘤治疗中的应用
Gülçin Tuğcu,Filiz Esra Önen Bayram,Hande Sipahi
Gülçin Tuğcu
Objectives: 4-(2-fluorophenoxy) quinoline derivatives constitute one of the chemical classes of hepatocyte growth factor receptor (c-MET) inhibitors, a promising treatment against various human tumors. There are three aim...
In silico Repurposing of Drugs for pan-HDAC and pan-SIRT Inhibitors: Consensus Structure-based Virtual Screening and Pharmacophore Modeling Investigations [0.03%]
基于结构的虚拟筛选和药效团模型在鉴定HDAC和Sirt抑制剂方面的计算再利用研究
Suat Sarı,Ahmet Avci,Ebru Koçak Aslan
Suat Sarı
Objectives: Drug repurposing is a highly popular approach to find new indications for drugs, which greatly reduces time and costs for drug design and discovery. Non-selective inhibitors of histone deacetylase (HDAC) isofo...
AQbD Driven Development of an RP-HPLC Method for the Quantitation of Abiraterone Acetate for its Pharmaceutical Formulations in the Presence of Degradants [0.03%]
基于AQbD的RP-HPLC开发方法用于药物制剂中阿比特龙 acetate的定量分析及其降解产物的影响
Bikash Ranjan Jena,Siva Prasad Panda,Umasankar Kulandaivelu et al.
Bikash Ranjan Jena et al.
Objectives: Abiraterone acetate is a well-known anticancer drug and a steroidal derivative of progesterone for treatment of patients with hormone-refractory prostate cancer. Chemometrics-assisted reverse phase high perfor...