Michel Kreutzer
Michel Kreutzer
The experimental approach has been at the center of my thoughts since my baccalaureate of "experimental sciences". Trained in neurosciences, I very quickly chose the field of ethology, thinking I would escape certain experimental approaches...
Aloïse Quesne
Aloïse Quesne
While the total replacement of animal experimentation was the goal set by the European Directive of 22 September 2010 on the protection of animals used for scientific purposes, it has to be said that it is still far from being achieved. The...
Francelyne Marano
Francelyne Marano
Alternative methods to animal testing are used in fundamental and clinical research, for the realization of studies for regulatory purposes, and also screening operations in the development of new molecules. They are based on in vitro (cell...
Georges Chapouthier
Georges Chapouthier
Initial practices involving experimentation with animals can be found in ancient Greece, but animal experimentation as understood in the modern world first emerged in the Renaissance. In the 19th century, the French scientist Claude Bernard...
[Alternative methods to animal testing: the need for funding and dissemination] [0.03%]
[替代动物试验的方法：资金和传播的需求]
Louis Schweitzer,Nikita Bachelard
Louis Schweitzer
The use of animals for scientific purposes brings a moral conflict between the necessity for human health and animal rights. Indeed, science has shown that most animals used in research are sentient beings, capable of suffering. Based on th...
[Interest and mechanisms of action of ketamine in alcohol addiction- A review of clinical and preclinical studies] [0.03%]
氯胺酮治疗酒精依赖有效性和作用机制的临床和基础研究进展
Fahd Hilal,Jérôme Jeanblanc,Mickaël Naassila
Fahd Hilal
Alcohol Use Disorder (AUD) is a psychiatric condition characterized by chronic and excessive drinking despite negative consequences on overall health and social or occupational functioning. There are currently limited treatment options avai...
Emilie Olié,Aisté Lengvenyte,Philippe Courtet
Emilie Olié
In France, suicidal behaviors remain a major public health issue. Depressed patients with suicidal ideation have more severe depressive symptoms, a more unfavorable disease course, and a greater number of suicide attempts than patients with...
Philippe Fossati
Philippe Fossati
Thirty percent of depressed patients are treatment resistant (TRD) suggesting the need of new therapeutic strategy. Recently, it has been shown that ketamine, an anesthetic agent with dissociative effects, has potent and rapid antidepressan...
Gisèle Pickering
Gisèle Pickering
Ketamine is now frequently used in the management of chronic pain refractory to conventional treatments. However, its efficacy and adverse effects appear variable in the literature in line with heterogeneous methodologies and modes of admin...
[Ketamine: a neuropsychotropic drug with an innovative mechanism of action] [0.03%]
氯胺酮：一种具有创新作用机制的神经精神药物
Jean-Philippe Guilloux,Thi Mai Loan Nguyen,Alain M Gardier
Jean-Philippe Guilloux
Ketamine, a non-competitive antagonist of the N-methyl-D-aspartate-glutamate receptor (R-NMDA), has a rapid (from 24 h post-dose) and prolonged (up to one week) antidepressant effect in treatment resistant depression and in rodent models of...