[Protein induced proximity and targeted degradations by new degraders: concepts, developments, challenges for clinical applications] [0.03%]
[由新分解物诱导的蛋白质邻近性和靶向降解：概念、发展和临床应用挑战]
Michèle Reboud-Ravaux
Michèle Reboud-Ravaux
The review is focused on recent drug discovery advances based on targeted protein degradation strategies. This new area of research has exploded leading to the development of potential drugs useful in a large variety of human diseases. They...
[IL-17A and IL-17F: from discovery to target of biologics - an illustrative example of translational research] [0.03%]
[从发现到生物靶点：白细胞介素17A和17F的转化研究实例]
Marie Robert,Pierre Miossec
Marie Robert
Interleukin (IL)-17A and then IL-17F have been discovered through their roles in chronic inflammatory diseases. These cytokines share 50% of sequence homology and bind to the same receptor made of the IL-17RA et IL-17RC chains. While they h...
Frédéric A Houssiau
Frédéric A Houssiau
Lupus nephritis remains the most frequent severe complication of systemic lupus erythematosus, leading to chronic renal impairment in 20 to 25% of cases. Current treatment is based on the combined use of immunosuppressive treatment and targ...
[Anti-Neutrophil Cytoplasmic Antigens (ANCA)-associated vasculitis: Current therapeutics] [0.03%]
[抗中性粒细胞胞浆抗体(ANCA)相关血管炎的治疗进展]
Loïc Guillevin
Loïc Guillevin
ANCA-associated vasculitis brings together three diseases, granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. This group of diseases has benefited over the last 3 decades from major...
[Rare Autoimmune Diseases Role of Genetics - Example of Systemic Lupus Erythematosus] [0.03%]
罕见自身免疫病的遗传学作用——系统性红斑狼疮病例分析
Maud Tusseau,Alexandre Belot
Maud Tusseau
Systemic lupus erythematosus (SLE) presents a complex clinical landscape with diverse manifestations, suggesting a multifactorial etiology. However, the identification of rare monogenic forms of the disease has shed light on specific geneti...
Xavier Mariette
Xavier Mariette
Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by a triad of key symptoms affecting almost all patients (salivary and lacrimal dryness, pain and fatigue) and extra-glandular systemic involvement affecting one to tw...
Anouk Charlot,Alix Lernould,Irène Plus et al.
Anouk Charlot et al.
Alzheimer's disease (AD) is a neurodegenerative disease that affects almost 1 million people in France and 55 million in the world. This pathology is a global health preoccupation because of the lack of efficient curative treatment and the ...
[How studies on curare contributed to the development of neurophysiological research in Brazil] [0.03%]
【箭毒研究如何促进了巴西神经生理学的发展】
Roberto Pereira Santos,Antonio Egídio Nardi,Marleide da Mota Gomes
Roberto Pereira Santos
Curare is a poison obtained from different species of plants in South America, which was used in arrows by the natives. Its lethal paralyzing potential and mechanism of action began to be explored in the 19th century. In this article, we hi...
[Multigenerational epigenetic inheritance in human: the past, present and perspectives] [0.03%]
[人类多代表观遗传继承：过去、现在和展望]
Fatima Smagulova
Fatima Smagulova
Nowadays, a growing body of evidence suggests that the developmental programs of each individual could be modified. The acquired new phenotypic changes could be persistent throughout the individual's life and even transmitted to the next ge...
[Disruptors of thyroid hormones: Which consequences for human health and environment?] [0.03%]
[扰甲状腺激素的作用机制及其对人类健康和环境的影响]
Patricia Rannaud-Bartaire,Jean-Baptiste Fini
Patricia Rannaud-Bartaire
Endocrine disruptors (EDs) of chemical origin are the subject of numerous studies, some of which have led to measures aimed at limiting their use and their impact on the environment and human health. Dozens of hormones have been described a...