Abla Benleulmi-Chaachoua,Stefanie Wojciech,Ralf Jockers
Abla Benleulmi-Chaachoua
G protein-coupled receptors (GPCRs), also known as seven transmembrane domain-spanning proteins (7TM), play an important role in tissue homeostasis and cellular and hormonal communication. GPCRs are targeted by a large panel of natural liga...
Laurent Debarbieux,Emilie Saussereau,Damien Maura
Laurent Debarbieux
Bacteriophages were discovered in the early 20th century and rapidly used to treat bacterial infections in humans. As the first specific antibacterial agents, they were used worldwide until antibiotics ramped up. Thereafter, rapidly forgott...
[Enigmatic archaeal viruses] [0.03%]
神秘的古菌病毒
Ariane Bize,Guennadi Sezonov,David Prangishvili
Ariane Bize
Viruses infecting microorganisms of the third domain of life, Archaea, are still poorly characterized: to date, only about fifty of these viruses have been isolated. Their hosts are hyperthermophilic, acidothermophilic, and extreme halophil...
[The great virus comeback] [0.03%]
[病毒的大反击]
Patrick Forterre
Patrick Forterre
Viruses have been considered for a long time as by-products of biological evolution. This view is changing now as a result of several recent discoveries. Viral ecologists have shown that viral particles are the most abundant biological enti...
Julie Lafaurie-Janvore
Julie Lafaurie-Janvore
Cell division is one of the most tightly controlled steps of the cell cycle. Indeed, the many steps of cell division have to be perfectly coordinated both in time and space in order to ensure an error-free division and an accurate transmiss...
[Restoring vision in blind patients following photoreceptor degeneration: clinical results and future challenges] [0.03%]
[视网膜感光细胞退化盲症患者的视力恢复：临床结果与未来挑战]
Amel Bendali,Henri Lorach,Milan Djilas et al.
Amel Bendali et al.
Retinal prostheses aim at restoring vision in patients blind from photoreceptor degeneration by electrically stimulating the residual retinal tissue. Currently, the most efficient implants are either inserted in the subretinal space or on t...
Botond Roska,Volker Busskamp,José Alain Sahel et al.
Botond Roska et al.
Retinitis pigmentosa (RP) is a hereditary retinal disease leading to blindness, which affects two million people worldwide. Restoring vision in these blind patients was proposed by gene delivery of microbial light-activated ionic channels o...
[Darwin or Lamarck? Understanding the ocular surface and its normal or abnormal differentiation in order to cure ocular surface destruction with corneal opacification] [0.03%]
【达尔文与拉马克之争】了解眼表及其正常的或异常的分化，以治疗角膜混浊的眼表破坏性疾病
François Majo,Michael Nicolas
François Majo
According to the World Health Organization, 5.1% of blindnesses or visual impairments are related to corneal opacification. Cornea is a transparent tissue placed in front of the color of the eye. Its transparency is mandatory for vision. Th...
Christophe Baudouin,Alexandre Denoyer,William Rostène
Christophe Baudouin
Second leading cause of blindness worldwide, glaucoma is an optic neuropathy related mainly but not exclusively to an increase of intraocular pressure. Angle closure glaucoma is related to a blockade of aqueous humor to the trabecular meshw...
Christian P Hamel
Christian P Hamel
Inherited retinal dystrophies are Mendelian neurodegenerative conditions. The mutations of the responsible genes lead both to cell dysfunction and cell death in the retina. The majority of these diseases are responsible for a progressive vi...