Angélique Vétillard,Wafa Bouzid
Angélique Vétillard
Animal venoms are complex mixtures containing simple organic molecules, proteins, peptides, and other bioactive elements with extraordinary biological properties associated with their ability to act on a number of molecular receptors in the...
Mohamed Amiche
Mohamed Amiche
The search for new bioactive molecules that could be used in therapeutics is a major public health issue, particularly in the treatment of certain diseases such as cancer. In this context the exploration of the venom of animals (snakes, amp...
[Venoms and medical research] [0.03%]
毒液与医学研究
Frédéric Ducancel
Frédéric Ducancel
Animal venoms are complex chemical cocktails, comprising a wide range of biologically active reticulated peptides that target with high selectivity and efficacy a variety of enzymes, membrane receptors, ion channels...Venoms can therefore b...
[Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin] [0.03%]
肺动脉高压、骨髓、内皮前体细胞和血清素的关系研究进展
Estelle Ayme-Dietrich,Sophie M Banas,Laurent Monassier et al.
Estelle Ayme-Dietrich et al.
Serotonin and bone-marrow-derived stem cells participate together in triggering pulmonary hypertension. Our work has shown that the absence of 5-HT2B receptors generates permanent changes in the composition of the blood and bone-marrow in t...
[Towards new targets for the treatment of pulmonary arterial hypertension : Importance of cell-cell communications] [0.03%]
[朝向治疗肺动脉高压的新目标：细胞间通讯的重要性]
Ly Tu,Maria-Rosa Ghigna,Carole Phan et al.
Ly Tu et al.
Pulmonary arterial hypertension (PAH) is a disorder in which mechanical obstruction of the pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial pressure (mPAP), resulting in a progressive functional decline ...
Etienne-Marie Jutant,Marc Humbert
Etienne-Marie Jutant
Pulmonary hypertension (PH) is a cardio-pulmonary disorder that may involve multiple clinical conditions and can complicate the majority of cardiovascular and respiratory diseases. Its definition is an increase in mean pulmonary artery pres...
Evariste Sanchez-Palencia
Evariste Sanchez-Palencia
This text is the written version of a talk at the Société de Biologie on February 17, 2016. It contains reflections of a non-biologist scientist on general problems of biological evolution, including the kind of causality involved, the id...
Sylvie Ricard-Blum,Frank Gondelaud
Sylvie Ricard-Blum
Several enzymes secreted in the extracellular space, such as matrix metalloproteinases and lysyl oxidase, are internalized and translocated to the nucleus, where they may act as proteases and transcription factors to regulate gene expressio...
[Neuronal cells derived from induced pluripotent stem cells to model motoneuron diseases] [0.03%]
[由诱导多能干细胞衍生的神经元细胞模拟运动神经元疾病]
Delphine Bohl
Delphine Bohl
Among motor neuron diseases, spinal muscular atrophy type 1 and amyotrophic lateral sclerosis are very aggressive diseases with no cure. With the breakthrough of human induced pluripotent stem cells, iPS, researchers have now at their dispo...
Noushin Dianat,Anne Weber,Anne Dubart-Kupperschmitt
Noushin Dianat
The liver is associated with many diseases including metabolic and cholestatic diseases, cirrhosis as well as chronic and acute hepatitis. However, knowledge about the mechanisms involved in the pathophysiology of these diseases remains lim...