[Ghrelin: a gastric hormone at the crossroad between growth and appetite regulation] [0.03%]
[胃饥饿素：一个在生长和摄食调节之间的交叉路口的胃激素]
Alexandra Labarthe,Virginie Tolle
Alexandra Labarthe
Ghrelin is a 28 amino acid peptide hormone synthesized within the gastrointestinal tract. Initially identified as the endogenous ligand of the GHS-R1a (Growth Hormone Secretagogue Receptor 1a), ghrelin is a powerful stimulator of growth hor...
[The neuropeptide 26RFa and its role in the regulation of energy metabolism] [0.03%]
神经肽26 RFamide及其在能量代谢调节中的作用
Nicolas Chartrel,Gaëtan Prévost,Mouna El Medhi et al.
Nicolas Chartrel et al.
The neuropeptide 26RFa, also referred to as QRFP (for pyroglutamilated RFamide peptide), is the latest member of the RFamide peptide family to be discovered. 26RFa and its N-extended form, 43RFa, have been characterized in all vertebrate cl...
[Hypothalamic inflammation and energy balance deregulations: focus on chemokines] [0.03%]
[下丘脑炎症和能量平衡紊乱：化学因子的作用]
Ophélia Le Thuc,Carole Rovère
Ophélia Le Thuc
The hypothalamus is a key brain region in the regulation of energy balance. It especially controls food intake and both energy storage and expenditure through integration of humoral, neural and nutrient-related signals and cues. Hypothalami...
Jean-François Guégan
Jean-François Guégan
In the light of a double approach, at first empirical, later theoretical and comparative, illustrated by the example of the Buruli ulcer and its mycobacterial agent Mycobacterium ulcerans on which I focused my research activity these last t...
Liliana Castro,Cedric Yapo,Pierre Vincent
Liliana Castro
Cyclic adenosine monophosphate (cAMP) and the cyclic-AMP dependent protein kinase (PKA) regulate a plethora of cellular functions in virtually all eukaryotic cells. In neurons, the cAMP/PKA signaling cascade controls a number of biological ...
[The cancer paradigm in pulmonary arterial hypertension: towards anti-remodeling therapies targeting metabolic dysfunction?] [0.03%]
[肺动脉高压中的癌症模式：朝向针对代谢功能障碍的抗重塑疗法？]
Sébastien J Dumas,Marc Humbert,Sylvia Cohen-Kaminsky
Sébastien J Dumas
Pulmonary arterial hypertension (PAH) is a rare, complex and multifactorial disease in which pulmonary vascular remodeling plays a major role ending in right heart failure and death. Current specific therapies of PAH that mainly target the ...
[Genes in the cAMP pathway causing skeletal dysplasia with or without hormonal resistance] [0.03%]
[cAMP通路基因导致的骨骼发育不良症兼有激素抵抗]
Caroline Silve
Caroline Silve
Acrodysostosis refers to a heterogeneous group of rare skeletal dysplasia that share characteristic features including severe brachydactyly, facial dysostosis and nasal hypoplasia. The literature describing acrodysostosis cases has been con...
Adénylyl cyclases et transdifférenciation des cellules musculaires lisses vasculaires : rôle dans le remodelage vasculaire pathologique [0.03%]
血管平滑肌细胞腺苷酸环化酶与转分化的角色在病理重塑中的作用研究
Marie Gueguen,Benjamin Vallin,Martine Glorian et al.
Marie Gueguen et al.
In response to various types of vascular stress, the smooth muscle cells of the vessel wall (VSMCs) change phenotype and acquire the capacity to react to abnormal signals. This phenomenon favors the involvement of these cells in the develop...
[Role and regulation of cAMP signaling in human trophoblast fusion] [0.03%]
人滋养细胞融合中的环磷酸腺苷信号通路的作用及调控机制研究进展
Pascale Gerbaud,Fatima Ferreira,Guillaume Pidoux
Pascale Gerbaud
In the human placenta, mononuclear cytotrophoblasts fuse to form multinucleated syncytia ensuring hormonal production and nutrient exchanges between the maternal and fetal circulation. The syncytial formation is necessary for the maintenanc...
[Cyclic nucleotide phosphodiesterases: role in the heart and therapeutic perspectives] [0.03%]
环核苷酸磷酸二酯酶：在心脏中的作用及治疗意义
Ibrahim Bedioune,Pierre Bobin,Sarah Karam et al.
Ibrahim Bedioune et al.
Cyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), thereby regulating multiple aspects of cardiac function. This highly diverse class of...