Marie Vétizou,Romain Daillère,Laurence Zitvogel
Marie Vétizou
The gut microbiota is known to affect digestion, protection against pathogens infection, immune system maturation and enteric nervous system development, but others links have also been established with diabetes, obesity, autism and cancer....
La génétique de l’hôte influe sur les écosystèmes microbiens par l’intermédiaire du système immunitaire de l’hôte [0.03%]
宿主的遗传因素通过宿主免疫系统影响微生物生态系统構築
Hela El Kafsi,Guy Gorochov,Martin Larsen
Hela El Kafsi
Genetic evolution of multicellular organisms occurred as a response to environmental challenges, in particular competition for nutrients, climatic change, physical and chemical stressors and pathogens. However organism fitness depends on bo...
Sergueï O Fetissov
Sergueï O Fetissov
Animals perceive alternating feelings of hunger and satiety, which constitute their daily rhythms of appetite and drive their feeding behavior. In humans, these rhythms include the onset of satiety about 20 min after meal ingestion and a du...
Patrice Debré
Patrice Debré
The microbiota designates the various flora of commensal microbes of living species. Most research in human focusing mainly on the intestinal microbiota, we will limit ourselves to its description and role in physiology and pathology. The i...
Rémy Burcelin
Rémy Burcelin
The aim of the review is to discuss about the role played by the defence crosstalk between the gut microbiota and the intestinal immune system, in the development of metabolic disease focusing on obesity and diabetes. Starting from physiolo...
Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni [0.03%]
选择性靶向病原体表观遗传酶治疗被忽视的疾病：以曼氏血吸虫乙酰化酶8（HDAC8）为例
Martin Marek,Tajith B Shaik,Manfred Jung et al.
Martin Marek et al.
Chromatin structure in eukaryotes and its modulation by epigenetic mechanisms enable the regulation of the different nuclear processes. Perturbation of epigenetic mechanisms can thus affect the proper functioning of cells, and numerous dise...
[Epigenetic regulations and cerebral plasticity: towards new therapeutic options in neurodegenerative diseases?] [0.03%]
表观遗传调控与脑可塑性：神经退行性疾病的新治疗选择？
Karine Merienne,Anne-Laurence Boutillier
Karine Merienne
Although revealed in the 1950's, epigenetics is still a fast-growing field. Its delineations continuously evolve and become clarified. In particular, "neuroepigenetics", a notion that encompasses epigenetic regulations associated with neuro...
Patrick Laurette,Dana Koludrovic,Sebastien Coassolo et al.
Patrick Laurette et al.
Malignant melanoma is a highly aggressive cancer with a propensity for early metastasis. Melanocyte transformation results predominantly from oncogenic mutations in BRAF, NRAS or NF1 leading to constitutive activation of the MAP kinase path...
Alexandre Berr,Xue Zhang,Wen-Hui Shen
Alexandre Berr
In the nucleus of eukaryotic cells, the chromatin states dictated by the different combinations of histone post-translational modifications, such as the methylation of lysine residues, are an integral part of the multitude of epigenomes inv...
[Hunger and satiety factors in the regulation of pleasure associated with feeding behavior] [0.03%]
[饥饿和饱腹因子在调节摄食行为相关快感中的作用]
Sergueï O Fetissov
Sergueï O Fetissov
Feeding is an instinctive behavior accompanied by rewarding feeling of pleasure during obtaining and ingesting food, corresponding to the preparatory and consummatory phases of motivated behavior, respectively. Perception of this emotional ...