Alexandre P España,David Santiago-Algarra,Lydie Pradel et al.
Alexandre P España et al.
Gene expression in higher eukaryotes is regulated through the involvement of transcription start site (TSS)-proximal (promoters) and -distal (enhancers) regulatory elements. Enhancer elements play an essential role during development and ce...
David Bikard,Rodolphe Barrangou
David Bikard
CRISPR-Cas systems (Clustered Regularly Interspaced Short Palindromic Repeats) are the adaptive immune system of bacteria and archaea. They target foreign genetic elements thanks to small RNAs able to guide Cas nucleases to destroy them. Th...
[Why so rare if so essentiel: the determinants of the sparse distribution of CRISPR-Cas systems in bacterial genomes] [0.03%]
为何重要却稀有：细菌基因组中CRISPR-Cas系统分布 sparse的决定因素
Aude Bernheim
Aude Bernheim
CRISPR-Cas (Cluster of Regularly Interspaced Short Palindromic Repeats) systems confer bacteria and archaea an adaptative immunity against phages and other invading genetic elements playing an important role in bacterial evolution. However,...
Christine Pourcel
Christine Pourcel
From 1987 and during the following 20 years, a few research teams exploring bacteria and archea genome sequences uncover the prokaryotic adaptative immune system made of the CRISPR sequence and associated cas genes. First believed to be sim...
Introduction [0.03%]
概述
William Rostène
William Rostène
[From sequence variability to structural and functional prediction: modeling of homologous protein families] [0.03%]
从序列变异到结构和功能预测：同源蛋白家族建模
Pierre Barrat-Charlaix,Martin Weigt
Pierre Barrat-Charlaix
Thanks to next-generation sequencing, the number of sequenced genomes grows rapidly, providing in particular ample examples for the sequence variability between homologous proteins. This article discusses data-driven probabilistic sequence ...
[Nextflow, an efficient tool to improve computation numerical stability in genomic analysis] [0.03%]
下一代计算基因组分析数值稳定性的高效工具
Paolo Di Tommaso,Evan W Floden,Cedrik Magis et al.
Paolo Di Tommaso et al.
Reproducing routine bioinformatics analysis is challenging owing to a combination of factors hard to control for. Nextflow is a flow management framework that uses container technology to insure efficient deployment and reproducibility of c...
[IGoR: a tool for learning and simulating the random generation of antigen receptors] [0.03%]
[IGoR：一个用于学习和模拟抗原受体随机生成的工具]
Thierry Mora
Thierry Mora
Antigen receptors, which form the base of the adaptive immune system, are created stochastically by a DNA editing process called V(D)J recombination. As high-throughput sequencing enables to study the repertoire of these receptors, it is no...
[Protein-protein interacting networks, their structures and disease-related mutations] [0.03%]
蛋白质-蛋白质相互作用网络及其结构和与疾病相关的突变
Franca Fraternali
Franca Fraternali
In recent years, the comparison of protein interactomes has identified conserved modules, that could represent functional nuclei with a common ancestry. Within this context, recent analyses of protein-protein interacting networks have led t...