Nelson Eduardo Martins,Roenick Proveti Olmo,Eric Roberto Guimarães Rocha Aguiar et al.
Nelson Eduardo Martins et al.
Insects are the most diverse group of animals. They can be infected by an extraordinary diversity of viruses. Among them, arthropod-borne viruses (arboviruses) can be transmitted to humans. High-throughput sequencing of small RNAs from inse...
Anna-Bella Failloux
Anna-Bella Failloux
The recent emergence or re-emergence of vector-borne diseases (VBD) and, more specifically, VBD associated with arboviruses such as dengue, chikungunya, Zika or yellow fever are not new events. The globalization of trade and travels as well...
[Treatment of the advanced HCC: A second revolution by using immunotherapy] [0.03%]
免疫治疗开启晚期肝癌治疗第二次革命
Laetitia Fartoux,Olivier Rosmorduc
Laetitia Fartoux
The treatment of advanced hepatocellular carcinoma has long been hopeless due to an absence of effective molecules and an underlying cirrhosis, compromising tolerance to conventional chemotherapy. A targeted anti-angiogenic therapy, sorafen...
Louis Lenfant,Morgan Rouprêt
Louis Lenfant
Immunotherapy as a treatment of solid malignancy is based on the activation of the immune system against tumor cells. Since 1976, intravesical instillation of Bacillus Calmette-Guérin (BCG) has been used widely for the treatment of non mus...
[Combinations of chemotherapy or radiotherapy with checkpoint inhibitors] [0.03%]
化疗或放疗与免疫检查点抑制剂联合使用的策略和思考
François Ghiringhelli
François Ghiringhelli
Recent advances in cancer immunotherapy with the development of anti-PD1/PD-L1 antibodies are revolutionizing cancer care. Nevertheless, the efficacy of these treatments in monotherapy is limited to a subpopulation representing about 25-30%...
[Anti-cancer vaccines: What future in anti-cancer immunotherapy strategies?] [0.03%]
抗癌疫苗：在抗癌免疫治疗策略方面的发展前景如何？
Eric Tartour
Eric Tartour
Tumor cells can be recognized by the immune system and in particular by cytotoxic CD8+T cells. From this observation was derived the concept that vaccination targeting these tumor-associated molecules was feasible. Preventive cancer vaccine...
Laura Chiossone,Eric Vivier
Laura Chiossone
After many years of research, recent advances shed a new light on the role of the immune system in cancer. New therapeutic antibodies, such as anti-PD-1/L1, that block the interactions of inhibitory receptors (immune checkpoint inhibitors, ...
Frédéric Gachon
Frédéric Gachon
Recent development in the proteomic technologies offers new perspectives in circadian biology and in particular the possibility to study post-translational modifications such as phosphorylation and acetylation. Applying in vivo proteomics o...
William Rostène
William Rostène
Natacha Zanin,Cedric M Blouin
Natacha Zanin
Membrane receptors control essential processes such as cell growth, adhesion, differentiation and metabolism through the activation of specific signaling pathways. Nowadays, these receptors are not only known to signal from the plasma membr...