William Rostène
William Rostène
[Metabolic pathways controlled by E3 ligases: an opportunity for therapeutic targeting] [0.03%]
[E3连接酶调控的代谢通路：靶向治疗的机会]
Daniel Taillandier
Daniel Taillandier
Since its discovery, the Ubiquitin Proteasome System (UPS) has been recognized for its major role in controlling most of the cell's metabolic pathways. In addition to its essential role in the degradation of proteins, it is also involved in...
[Induced degradation of proteins by PROTACs and other strategies: towards promising drugs] [0.03%]
[利用PROTACs和其他策略诱导蛋白质降解：朝向有前景的药物]
Michèle Reboud-Ravaux
Michèle Reboud-Ravaux
Targeted protein degradation (TPD), discovered twenty years ago through the PROTAC technology, is rapidly developing thanks to the implication of many scientists from industry and academia. PROTAC chimeras are heterobifunctional molecules a...
[The proteasome - structural aspects and inhibitors: a second life for a validated drug target] [0.03%]
蛋白酶体-结构特点及其抑制剂：一个被验证的药物作用靶点的“第二生命”
Michèle Reboud-Ravaux
Michèle Reboud-Ravaux
The proteasome is the central component of the adaptable ubiquitin proteasome system (UPS) discovered in the 1980's. It sustains protein homeostasis (proteostasis) under a large variety of physiological and pathological conditions. Its dysr...
La Société de Biologie de Strasbourg : 100 ans au service de la science et de la société [0.03%]
斯特拉斯堡生物学会：百年来献身于科学和社会事业
Pierre Antony,Sylvie Fournel,Joffrey Zoll et al.
Pierre Antony et al.
Founded in 1919, the Society of Biology of Strasbourg (SBS) is a learned society whose purpose is the dissemination and promotion of scientific knowledge in biology. Subsidiary of the Society of Biology, the SBS celebrated its Centenary on ...
[Developmental plasticity in plants: an interaction between hormones and epigenetics at the meristem level] [0.03%]
植物发育的可塑性：激素与表观遗传在分生组织水平上的相互作用
Julien Vigneaud,Stéphane Maury
Julien Vigneaud
Plants are fixed organisms with continuous development throughout their life and great sensitivity to environmental variations. They react in this way by exhibiting large developmental phenotypic plasticity. This plasticity is partly contro...
Anouk Charlot,Ombline Conrad,Joffrey Zoll
Anouk Charlot
Cancer is a disease that can appear in several tissues and that kills more than 150 000 people in France every year. Cancer cells have mutations in their genome that lead to changes in their metabolism, compared to healthy cells. They use m...
[The pre-gastrulation embryonic human development: future models and societal concerns] [0.03%]
胚胎着床前的人类发育：未来模型和伦理问题
Inès Jmel Boyer,Emmanuel García Sánchez
Inès Jmel Boyer
Infertility, early miscarriages and congenital malformations are major public health issues that are frequent and poorly understood. Until now, what is known about early human development originates from two main sources: studies of human e...
Laureline Boulanger,Amélie Héraud,Dorian Martzloff et al.
Laureline Boulanger et al.
The earth is currently facing an unprecedented biodiversity loss, which is taking such proportions that it is sometimes considered to be the sixth mass extinction. Human activities are the main cause of this alarming ecological crisis and t...
Mélanie Béhé,Eliane Bou Orm,Léa Hahn et al.
Mélanie Béhé et al.
In the 1960s, the concept of ecological engineering was theorized by Howard Odum, who showed the possibility of controlling the evolutionary trajectories of ecosystems by influencing their natural dynamics. H. Odum gave the definition of ec...