Veronica E Farag,Elsie A Devey,Kam W Leong
Veronica E Farag
The potential of regenerative medicine in the clinical space is vast, given its ability to repair and replace damaged tissues, restore lost functions due to age or disease, and transform personalized therapy. Traditional regenerative medici...
Kai-Bo Wang,Yingying Wang,Jonathan Dickerhoff et al.
Kai-Bo Wang et al.
DNA guanine (G)-quadruplexes (G4s) are unique secondary structures formed by two or more stacked G-tetrads in G-rich DNA sequences. These structures have been found to play a crucial role in highly transcribed genes, especially in cancer-re...
Real-Time Programmable Nonlinear Wavefront Shaping with Si Metasurface Driven by Genetic Algorithm [0.03%]
由遗传算法驱动的硅基超表面实时可编程非线性波前整形技术
Ze Zheng,Gabriel Sanderson,Soheil Sotoodeh et al.
Ze Zheng et al.
Nonlinear wavefront shaping is crucial for advancing optical technologies, enabling applications in optical computation, information processing, and imaging. However, a significant challenge is that once a metasurface is fabricated, the non...
Alexander K Zinsmaier,Eric J Nestler,Yan Dong
Alexander K Zinsmaier
Understanding the cellular mechanisms of drug addiction remains a key task in current brain research. While neuron-based mechanisms have been extensively explored over the past three decades, recent evidence indicates a critical involvement...
The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers [0.03%]
美罗培南、阿维巴克塔和金属β-内酰胺酶抑制剂的三重组合可优化针对不同β-内酰胺酶产生菌的抗菌覆盖范围
Zhuoren Ling,Alistair James Macdonald Farley,Aditya Lankapalli et al.
Zhuoren Ling et al.
This work explores the potential of a triple combination of meropenem (MEM), a novel metallo-β-lactamase (MBL) inhibitor (indole-2-carboxylate 58 (InC58)), and a serine-β-lactamase (SBL) inhibitor (avibactam (AVI)) for broad-spectrum acti...
Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection [0.03%]
仿生血小板膜包被的纳米颗粒可阻断金黄色葡萄球菌细胞毒性并抵抗致死性全身感染
Jwa-Kyung Kim,Satoshi Uchiyama,Hua Gong et al.
Jwa-Kyung Kim et al.
Staphylococcus aureus is a leading human pathogen capable of producing severe invasive infections such as bacteremia, sepsis and endocarditis with high morbidity and mortality, exacerbated by expanding antibiotic-resistance exemplified by m...
Machine-Learning-Assisted Design of Deep Eutectic Solvents Based on Uncovered Hydrogen Bond Patterns [0.03%]
基于未被发现的氢键模式的机器学习辅助设计深吴溶剂
Usman L Abbas,Yuxuan Zhang,Joseph Tapia et al.
Usman L Abbas et al.
Non-ionic deep eutectic solvents (DESs) are non-ionic designer solvents with various applications in catalysis, extraction, carbon capture, and pharmaceuticals. However, discovering new DES candidates is challenging due to a lack of efficie...
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota [0.03%]
肠上皮Axin1缺陷通过改变肠道菌群对抗结肠炎的作用
Shari Garrett,Yongguo Zhang,Yinglin Xia et al.
Shari Garrett et al.
Intestinal homeostasis is maintained by specialized host cells and the gut microbiota. Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulation has been implicated in inflammation and col...
Putative Mode of Action of the Monoterpenoids Linalool, Methyl Eugenol, Estragole, and Citronellal on Ligand-Gated Ion Channels [0.03%]
单萜类化合物(linalool,甲基丁香酚,estragole和柠檬醛)对配体门控离子通道的作用方式假设
Amy S Li,Akimasa Iijima,Junhao Huang et al.
Amy S Li et al.
Essential oil has been used as sedatives, anticonvulsants, and local anesthetics in traditional medical remedies; as preservatives for food, fruit, vegetable, and grain storage; and as bio-pesticides for food production. Linalool (LL), alon...
Super-Resolution Displacement Spectroscopic Sensing over a Surface "Rainbow" [0.03%]
表面“彩虹”上的超分辨率位移光谱传感技术
Lyu Zhou,Nan Zhang,Chang Chieh Hsu et al.
Lyu Zhou et al.
Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy, sensing, and medical imaging. For these applications, miniaturized spectrometers are desirable to enable the on-chip ana...