Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions [0.03%]
中药复方干预的随机对照试验的透明度和报告特征分析
Juan Wang,Dongni Shi,Yaochen Wang et al.
Juan Wang et al.
Unlocking the potential of bispecific ADCs for targeted cancer therapy [0.03%]
双特异抗体药物偶联物的潜力及其在靶向癌症治疗中的应用
Hongye Zeng,Wenjing Ning,Xue Liu et al.
Hongye Zeng et al.
Antibody-drug conjugates (ADCs) are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by linkers. These innovative compounds enable precise drug delivery to tumor cells, minimizing harm to normal tissues and o...
Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma [0.03%]
单细胞RNA测序揭示了神经母细胞瘤肿瘤进展和转移背后的转录组程序
Zhe Nian,Dan Wang,Hao Wang et al.
Zhe Nian et al.
Neuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes. However, the molecular mechanisms triggering NB metastasi...
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China [0.03%]
Janus激酶1抑制剂治疗中重度特应性皮炎中国真实世界有效性及安全性的单中心前瞻性研究
Yihui Chen,Qiaozhi Cao,Cong Peng et al.
Yihui Chen et al.
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial [0.03%]
针刺治疗难治性肠易激综合征患者的疗效研究：随机对照试验
Jun Zhao,Hui Zheng,Xin Wang et al.
Jun Zhao et al.
Previous studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled trial to assess the efficacy and sa...
Acquired immune thrombotic thrombocytopenic purpura (TTP) associated with inactivated COVID-19 vaccine CoronaVac [0.03%]
与灭活新冠病毒疫苗科兴中维株相关的获得性免疫性血栓性血小板减少性紫癜(TTP)
Zhangbiao Long,Suyu Jiang,Honglei Xin et al.
Zhangbiao Long et al.
Corona virus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has affected the whole world. Acquired thrombotic thrombocytopenic purpura (TTP) has been reported after administration of mR...
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α-mitochondrial complex IV axis [0.03%]
长链非编码RNA Gm20257通过调节PGC-1α-线粒体复合物IV轴缓解病理性心脏肥厚
Tong Yu,Qiang Gao,Guofang Zhang et al.
Tong Yu et al.
Pathological cardiac hypertrophy, a major contributor to heart failure, is closely linked to mitochondrial function. The roles of long noncoding RNAs (lncRNAs), which regulate mitochondrial function, remain largely unexplored in this contex...
Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer [0.03%]
表观遗传沉默的BEND4基因可作为ATM抑制剂治疗胰腺癌的合成致死标志物
Yuanxin Yao,Honghui Lv,Meiying Zhang et al.
Yuanxin Yao et al.
Synthetic lethality is a novel model for cancer therapy. To understand the function and mechanism of BEN domain-containing protein 4 (BEND4) in pancreatic cancer, eight cell lines and a total of 492 cases of pancreatic neoplasia samples wer...
Regulations of m6A and other RNA modifications and their roles in cancer [0.03%]
m6A及其他RNA修饰的调控及在癌症中的作用
Xin-Hui Chen,Kun-Xiong Guo,Jing Li et al.
Xin-Hui Chen et al.
RNA modification is an essential component of the epitranscriptome, regulating RNA metabolism and cellular functions. Several types of RNA modifications have been identified to date; they include N6-methyladenosine (m6A), N1-methyladenosine...
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma [0.03%]
CD39中度表达的GPC3-CAR-T细胞高效率杀伤肝癌细胞
Fan Zou,Jialiang Wei,Jialang Zhuang et al.
Fan Zou et al.
CD39 serves as a crucial biomarker for neoantigen-specific CD8+ T cells and is associated with antitumor activity and exhaustion. However, the relationship between CD39 expression levels and the function of chimeric antigen receptor T (CAR-...