Ethanol Extract of Bupleurum falcatum Improves Functional Recovery by Inhibiting Matrix Metalloproteinases-2 and -9 Activation and Inflammation after Spinal Cord Injury [0.03%]
防风草乙醇萃取物借由抑制脊髓伤害后之发炎反应及其对基质金属蛋白脢-2及-9活性变化的调控进而改善其功能性恢复作用
Jee Youn Lee,Hwang Soo Kim,Tae Hwan Oh et al.
Jee Youn Lee et al.
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade the extracellular matrix and other extracellular proteins. Upregulation of MMPs activity is known to be required for the inflammatory cell infiltration after sp...
Effect of Berberine on Cell Survival in the Developing Rat Brain Damaged by MK-801 [0.03%]
小檗碱对氯胺酮所致大鼠发育期脑损伤的神经保护作用研究
Taehwan Lee,Hwon Heo,Yunhee Kim Kwon
Taehwan Lee
Berberine is an isoquinoline alkaloid isolated from goldenthread, Coptidis Rhizoma and shown to have many biological and pharmacological effects. We previously reported that berberine promotes cell survival and differentiation of neural ste...
5-hydroxy-L-tryptophan Suppressed Food Intake in Rats Despite an Increase in the Arcuate NPY Expression [0.03%]
5-羟基-L-色氨酸通过增加下丘脑弓状核NPY表达而抑制大鼠摄食行为
Young Wha Moon,Si Ho Choi,Sang Bae Yoo et al.
Young Wha Moon et al.
This study was conducted to define the underlying mechanism of hypophagia induced by increased central serotonergic action. Rats received 3 daily injections of 5-hydroxy-L-tryptophan (5-HTP), a serotonin precursor, at a dose of 100 mg/kg/10...
Wonjin Ji,Ilho Ha
Wonjin Ji
Alzheimer's disease, the most common cause of dementia, is characterized by two major pathological hallmarks: amyloid plaques and neurofibrillary tangles. Based on these two indicators, an amyloid cascade hypothesis was proposed, and accord...
Karen L O&#x;Malley
Karen L O&#x;Malley
New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since many studies suggest that...
Organotypic spinal cord slice culture to study neural stem/progenitor cell microenvironment in the injured spinal cord [0.03%]
组织型脊髓片培养技术在研究损伤脊髓内神经干细胞/祖细胞微环境中的应用
Hyuk Min Kim,Hong Jun Lee,Man Young Lee et al.
Hyuk Min Kim et al.
The molecular microenvironment of the injured spinal cord does not support survival and differentiation of either grafted or endogenous NSCs, restricting the effectiveness of the NSC-based cell replacement strategy. Studying the biology of ...
Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5 [0.03%]
LRRK2及其互作蛋白Rab5共同调控神经突生长
Hye Young Heo,Kwang-Soo Kim,Wongi Seol
Hye Young Heo
Neurite outgrowth and its maintenance are essential aspects of neuronal cells for their connectivity and communication with other neurons. Recent studies showed that over-expression of either leucine-rich repeat kinase 2 (LRRK2), whose muta...
Etoposide Reduces Peroxynitrite-Induced Cytotoxicity via Direct Scavenging Effect [0.03%]
依托泊苷通过直接清除过氧亚硝酸阴离子而减少其引起的细胞毒性
In-Young Choi,Won-Ki Kim
In-Young Choi
Previously, we reported that glucose-deprived astrocytes are more vulnerable to the cytotoxicity of peroxynitrite, the reaction product of nitric oxide and superoxide anion. The augmented vulnerability of glucose-deprived astrocytes to pero...
Nitric oxide is an essential mediator for neuronal differentiation of rat primary cortical neuron cells [0.03%]
一氧化氮介导原发性皮层神经元分化的作用及机制研究
Soo-Jin Oh,Jee-In Heo,Yoon-Jung Kho et al.
Soo-Jin Oh et al.
Nitric oxide (NO) regulates proliferation, differentiation and survival of neurons. Although NO is reported to involve in NGF-induced differentiation of PC12 cells, the role of NO has not been characterized in primary neuron cells. Therefor...
A winged-helix transcription factor foxg1 induces expression of mss4 gene in rat hippocampal progenitor cells [0.03%]
转录因子foxg1在大鼠海马神经祖细胞中诱导激活mss4基因的表达
Ju-Suk Nam,Haijie Yang,Nam-Ho Kim et al.
Ju-Suk Nam et al.
Foxg1 (previously named BF1) is a winged-helix transcription factor with restricted expression pattern in the telencephalic neuroepithelium of the neural tube and in the anterior half of the developing optic vesicle. Previous studies have s...