Changes in the Histone Acetylation Patterns during the Development of the Nervous System [0.03%]
神经系统发育过程中组蛋白乙酰化模式的变化
Bongki Cho,Hyun Jung Kim,Hyun Kim et al.
Bongki Cho et al.
Epigenetic modification such as DNA methylation and histone acetylation plays essential roles in many aspects of cellular function and development of animals. There is an increasing amounts of evidence for dynamic changes in the histone ace...
The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders [0.03%]
阿尔茨海默病及相关障碍中细胞骨架异常与线粒体功能障碍之间的界面关系
David E Kang,Seung Eon Roh,Jung A Woo et al.
David E Kang et al.
The major defining pathological hallmarks of Alzheimer's disease (AD) are the accumulations of Aβ in senile plaques and hyperphosphorylated tau in neurofibrillary tangles and neuropil threads. Recent studies indicate that rather than these...
Differences between Physostigmine- and Yohimbine-induced States Are Visualized in Canonical Space Constructed from EEG during Natural Sleep-wake Cycle in Rats [0.03%]
基于大鼠自然醒睡周期EEG构建的经典空间可视化Physostigmine和Yohimbine诱导状态之间的差异
Maan-Gee Lee,Minji Kim,Mootaek Roh et al.
Maan-Gee Lee et al.
Although quantitative EEG parameters, such as spectral band powers, are sensitive to centrally acting drugs in dose- and time-related manners, changes of the EEG parameters are redundant. It is desirable to reduce multiple EEG parameters to...
Rapid Disruption of Cellular Integrity of Zinc-treated Astroglia Is Regulated by p38 MAPK and Ca-dependent Mechanisms [0.03%]
锌诱导星形胶质细胞快速解体由p38MAPK和Ca2+依赖性机制调控
Joo-Young Im,Hyo-Jin Joo,Pyung-Lim Han
Joo-Young Im
Cultured cortical primary astroglia treated with zinc died while rapidly detached from culture plates, a distinct part of zinc-treated astroglia. In the present study, we investigated the mechanism underlying the rapid change in the morphol...
Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death [0.03%]
DYRK1A通过活化ASK1-MAPK疼痛通路正向调控细胞凋亡
Hyoung Kyoung Choi,Kwang Chul Chung
Hyoung Kyoung Choi
Dual-specificity tyrosine (Y)-phosphorylation-regulated protein kinase 1A (Dyrk1A) is the mammalian homologue of Drosophila melanogaster minibrain and its human gene is mapped to the Down syndrome critical region of chromosome 21. Dyrk1A ph...
Minyeop Nahm,Seungbok Lee
Minyeop Nahm
Rho small GTPases control multiple aspects of neuronal morphogenesis by regulating the assembly and organization of the actin cytoskeleton. Although they are negatively regulated by GTPase activating proteins (GAPs), the roles of RhoGAPs in...
Mammalian molecular clocks [0.03%]
哺乳动物的分子钟
Ilmin Kwon,Han Kyoung Choe,Gi Hoon Son et al.
Ilmin Kwon et al.
As a consequence of the Earth's rotation, almost all organisms experience day and night cycles within a 24-hr period. To adapt and synchronize biological rhythms to external daily cycles, organisms have evolved an internal time-keeping syst...
Peter Riederer,Gerd Laux
Peter Riederer
Monoamine oxidase inhibitors (MAO-I) belong to the earliest drugs tried in Parkinson's disease (PD). They have been used with or without levodopa (L-DOPA). Non-selective MAO-I due to their side-effect/adverse reaction profile, like tranylcy...
Gookhwa Kim,Hyojeong Yun,Munho Ryu et al.
Gookhwa Kim et al.
Stroke is a leading cause of adult disability and the second-leading cause of death in Korea. It is also the third-leading cause of death in the United States, leading to a serious demand for new interventions to improve the quality of life...
Selective susceptibility of human dopaminergic neural stem cells to dopamine-induced apoptosis [0.03%]
人源多巴胺能神经干细胞对多巴胺诱导的细胞凋亡的选择性易感性
Sung-Man Jeon,Sang-Myung Cheon,Hye-Rahn Bae et al.
Sung-Man Jeon et al.
Dysfunctions of ubiquitin-proteasome system and toxicity of dopamine have been known as the key mechanisms in the pathogenesis of Parkinson's disease (PD) and proteasome inhibitors are widely used in experimental models of PD to reproduce c...