Effects of polychlorinated biphenyls on the development of neuronal cells in growth period; structure-activity relationship [0.03%]
多氯联苯对生长期内神经细胞发育影响的结构活性关系研究
Youngrok Do,Dong Kuck Lee
Youngrok Do
Polychlorinated biphenyls (PCBs) are accumulated in our body through food chain and cause a variety of adverse health effects including neurotoxicities such as cognitive deficits and motor dysfunction. In particular, neonates are considered...
Inactivation of the medial prefrontal cortex interferes with the expression but not the acquisition of differential fear conditioning in rats [0.03%]
内侧前额叶皮层失活干扰大鼠区别性恐惧条件反射的表达但不影响其获得
Yeon Kyung Lee,June-Seek Choi
Yeon Kyung Lee
The medial prefrontal cortex (mPFC) has been implicated in the processing of emotionally significant stimuli, particularly the inhibition of inappropriate responses. We examined the role of the mPFC in regulation of fear responses using a d...
Repeated Short-term (2h×14d) Emotional Stress Induces Lasting Depression-like Behavior in Mice [0.03%]
重复短期（2小时×14天）情绪压力可诱导小鼠持久的抑郁样行为
Kyoung-Shim Kim,Hye-Joo Kwon,In-Sun Baek et al.
Kyoung-Shim Kim et al.
Chronic behavioral stress is a risk factor for depression. To understand chronic stress effects and the mechanism underlying stress-induced emotional changes, various animals model have been developed. We recently reported that mice treated...
Jin-A Lee,Fen-Biao Gao
Jin-A Lee
The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRN...
Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival? [0.03%]
神经元自噬：神经细胞生存的管家还是战士？
Jin-A Lee
Jin-A Lee
Neurons have highly dynamic cellular processes for their proper functions such as cell growth, synaptic formation, or synaptic plasticity by regulating protein synthesis and degradation. Therefore, the quality control of proteins in neurons...
Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats [0.03%]
麻醉大鼠主嗅球中NIRS测量的气味依赖性血流动力学响应
Hyun Joo Lee,Yunjun Nam,Chin Su Koh et al.
Hyun Joo Lee et al.
In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were pres...
Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice [0.03%]
A53T alpha-突变型突触核蛋白转基因小鼠肠神经系统中突触核蛋白病的传播
He-Jin Lee,Ji-Eun Suk,Kyung-Won Lee et al.
He-Jin Lee et al.
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by abnormal deposition of α-synuclein aggregates in many regions of the central and peripheral nervous systems. Accumulating evidence suggests that the α-synuc...
Effect of Strychinine, a Glycine Inhibitor, on the Programmed Cell Death of Motoneurons during the Chick Development [0.03%]
毛果芸香碱(甘氨酸抑制剂)对发育鸡胚运动神经元程序性死亡的影响
Joo Yeon Kim,So Yoen Choi,Hyun Kim et al.
Joo Yeon Kim et al.
In this study, we report that the treatment of strychinine (STR), an inhibitor of glycine receptor, induced premature onset of programmed cell death (PCD) of developing chick motoneurons (MNs). Treatment of STR on E4 chick embryo increased ...
Chlorogenic Acid Improves Neuroprotective Effect of PEP-1-Ribosomal Protein S3 Against Ischemic Insult [0.03%]
氯ogenic酸可增强PEP-1-RPS3对抗缺血损伤的神经保护作用
Eun Hee Ahn,Dae Won Kim,Min Jea Shin et al.
Eun Hee Ahn et al.
Chlorogenic acid (CGA) possesses various biological activities such as anti-oxidant, anti-inflammatory, and anti-diabetic activities. In the present study, we examined the effect of CGA on the transduction efficiency of PEP-1-ribosomal prot...
Hyung-Mun Yun,Hyewhon Rhim
Hyung-Mun Yun
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological responses through 7 different 5-HT receptor families: 5-HT(1), ...