Environmental-genetic interactions in the pathogenesis of Parkinson's disease [0.03%]
环境-基因相互作用在帕金森病发病机制中的作用
Yoshio Tsuboi
Yoshio Tsuboi
To date, numerous case-control studies have shown the complexity of the pathogenesis of Parkinson's disease (PD). In terms of genetic factors, several susceptibility genes are known to contribute to the development of PD, including α-synuc...
Messages from the brain connectivity regarding neural correlates of consciousness [0.03%]
来自脑连接性关于意识神经相关性的信息
Seung-Hyun Jin,Chun Kee Chung
Seung-Hyun Jin
Consciousness has become a legitimate theme of neuroscientific discourse over the last two decades. Neuroscientific investigation seeking neural correlates of consciousness (NCC) has ranged from the neuronal level to the system level. Regar...
Serotonin and synaptic transmission at invertebrate neuromuscular junctions [0.03%]
五羟色胺与无脊椎动物神经肌接头的突触传递功能
Wen-Hui Wu,Robin L Cooper
Wen-Hui Wu
The serotonergic system in vertebrates and invertebrates has been a focus for over 50 years and will likely continue in the future. Recently, genomic analysis and discovery of alternative splicing and differential expression in tissues have...
Hideaki Matsui,Roberto Gavinio,Ryosuke Takahashi
Hideaki Matsui
The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson's disease (PD) models we developed using toxin treatment and genetic engineering. 1-Methyl-4-phenyl-1,2,3,4-tetra...
Sensory Axon Regeneration: A Review from an in vivo Imaging Perspective [0.03%]
感觉轴突再生：一种基于活体 imaging 的回顾性研究视角
Seung Baek Han,Hyukmin Kim,Andrew Skuba et al.
Seung Baek Han et al.
Injured primary sensory axons fail to regenerate into the spinal cord, leading to chronic pain and permanent sensory loss. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Why axons stop or turn around at t...
Capsaicin Blocks the Hyperpolarization-Activated Inward Currents via TRPV1 in the Rat Dorsal Root Ganglion Neurons [0.03%]
辣椒素通过TRPV1阻断大鼠背根神经节神经元的超极化激活的内向电流
Jiyeon Kwak
Jiyeon Kwak
Capsaicin, the pungent ingredient in hot pepper, activates nociceptors to produce pain and inflammation. However, prolonged exposures of capsaicin will cause desensitization to nociceptive stimuli. Hyperpolarization-activated cation current...
Hue Vang,Gehoon Chung,Hyun Yeong Kim et al.
Hue Vang et al.
The long belief that dental primary afferent (DPA) neurons are entirely composed of nociceptive neurons has been challenged by several anatomical and functional investigations. In order to characterize non-nociceptivepopulation among DPA ne...
Differential Expressions of Synaptogenic Markers between Primary Cultured Cortical and Hippocampal Neurons [0.03%]
原发培养皮层和海马神经元突触发生标记物的差异表达模式研究
Yun-Gi Kim,Young-Il Lee
Yun-Gi Kim
Primary dissociated neuronal cultures are widely used research tools to investigate of pathological mechanisms and to treat various central and peripheral nervous system problems including trauma and degenerative neuronal diseases. We intro...
Santosh Ramamurthy,Gabriele Ronnett
Santosh Ramamurthy
5'-adenosine monophosphate-activated protein kinase (AMPK) is an evolutionarily conserved cellular and organismal energy integrator that responds to numerous stimuli with the overall intention to facilitate energy conservation and enhance e...
The role of protein phosphorylation in the gustatory cortex and amygdala during taste learning [0.03%]
味觉学习过程中蛋白磷酸化在味觉皮层和杏仁体的作用研究
Chinnakkaruppan Adaikkan,Kobi Rosenblum
Chinnakkaruppan Adaikkan
Protein phosphorylation and dephosphorylation form a major post-translation mechanism that enables a given cell to respond to ever-changing internal and external environments. Neurons, similarly to any other cells, use protein phosphorylati...