Meta-analysis of levamisole absorption and disposition across diverse species using a minimal physiologically-based pharmacokinetic model [0.03%]
基于最小生理药动学模型的雷莫司琼跨物种吸收和分布的 meta 分析
ChunFu Cheng,Yoo-Seong Jeong,William J Jusko
ChunFu Cheng
Purpose: Pharmacokinetic (PK) data for levamisole, an important immunostimulant and antiparasitic agent, were identified in 18 species providing sufficient PK data following oral (PO) and/or intravenous (IV) administratio...
Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation [0.03%]
两性离子藻酸盐衍生物作为增强血液循环的新传输平台
Hyeri Lee,Yan Li,Kai Bao et al.
Hyeri Lee et al.
Purpose: Poly(ethylene glycol) (PEG), a synthetic polymer known for its hydrophilicity and biocompatibility, has long been used in drug delivery systems to prevent non-specific protein adsorption and to extend the blood c...
Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals [0.03%]
提高生物制药稳定性和传递效率的干燥技术方面的最新进展
Fakhrossadat Emami,Mahsa Keihan Shokooh,Seyed Jamaleddin Mostafavi Yazdi
Fakhrossadat Emami
Background: Most biopharmaceuticals are developed in liquid dosage forms that are less stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an effective drying technique in the pre...
Nanomedicine-based commercial formulations: current developments and future prospects [0.03%]
基于纳米医学的商业配方：当前的发展和未来的前景
Raj Kumar Thapa,Jong Oh Kim
Raj Kumar Thapa
Background: In recent decades, there has been a considerable increase in the number of nanomedicine-based formulations, and their advantages, including controlled/targeted drug delivery with increased efficacy and reduced...
COVID-19 drugs: potential interaction with ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein [0.03%]
新冠肺炎药物与ATP结合盒转运蛋白地芬酯和乳腺癌抗性蛋白的潜在相互作用
Jaeok Lee,Jihye Kim,Jiyeon Kang et al.
Jaeok Lee et al.
Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has resulted in acute respiratory distress, fatal systemic manifestations (extrapulmonary as well as...
Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments [0.03%]
人工携氧载体型红细胞代用品的研究进展：从传统技术到前沿科技的体内外评估方法综述
Nijaya Mohanto,Young-Joon Park,Jun-Pil Jee
Nijaya Mohanto
Background: Several circumstances such as accidents, surgery, traumatic hemorrhagic shock, and other causalities cause major blood loss. Allogenic blood transfusion can be resuscitative for such conditions; however, it ha...
Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors [0.03%]
药物鼻给脑递送：关键靶点与主要影响因素探索
Seung-Hyun Jeong,Ji-Hun Jang,Yong-Bok Lee
Seung-Hyun Jeong
Background: Cranial nerve-related diseases such as brain tumors, Alzheimer's disease, and epilepsy are serious diseases that continue to threaten human. Brain-related diseases are increasing worldwide, including in the Un...
Jongyoon Shinn,Nuri Kwon,Seon Ah Lee et al.
Jongyoon Shinn et al.
Background: Currently nanomedicines are the focus of attention from researchers and clinicians because of the successes of lipid-nanoparticles-based COVID-19 vaccines. Nanoparticles improve existing treatments by providin...
Recent advancements in lipid-mRNA nanoparticles as a treatment option for cancer immunotherapy [0.03%]
用于癌症免疫治疗的脂质-mRNA纳米颗粒的最新进展
Prajeena Karmacharya,Basavaraj Rudragouda Patil,Jong Oh Kim
Prajeena Karmacharya
Background: Cancer remains a serious health concern worldwide, and different approaches are being developed for its treatment. The strategy to use the immune system as an approach for treating cancer has recently gained m...
Effects of 1α,25-dihydroxyvitamin D3 on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats [0.03%]
1α,25-二羟基维生素D3对内源性有机阳离子/肉毒碱转运蛋白1底物麦角硫因的大鼠药代动力学和组织分布的影响
Dang-Khoa Vo,Thi-Thao-Linh Nguyen,Han-Joo Maeng
Dang-Khoa Vo
Purpose: This study aimed to investigate the effects of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the expression levels of organic cation/carnitine transporter 1 (OCTN1) as well as the pharmacokinetics and biodistributi...