Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-α and IFNγ-stimulated Primary Cultured Astrocytes [0.03%]
乳糖甘油酯介导TNF-α和IFNγ刺激的原代培养星形胶质细胞中粘附分子的表达
Jin-Koo Lee,Jin-Kyu Kim,Soo-Hyun Park et al.
Jin-Koo Lee et al.
Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-α and IFNγ (CM)-stimulated astrocytes. We have observed that stimulation of astrocytes with CM increased the gene expression of...
Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells [0.03%]
安非他明通过PKCβ激活诱导PC12细胞中ERM蛋白磷酸化
Ha Jin Jeong,Jeong-Hoon Kim,Songhee Jeon
Ha Jin Jeong
Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation leve...
Molecular characterization and mitogenic activity of a lectin from purse crab philyra pisum [0.03%]
来自甲壳动物Portunus Pisumm的糖蛋白PPL的分子特性及其增殖活性的研究
Jong Cheon Na,Byung Tae Park,Woo Hyuk Chung et al.
Jong Cheon Na et al.
A lectin from the hemolymph of purse crab, Philyra pisum, was found to have anti-proliferative activity on human lung cancer cells by our laboratory. In this study, P. pisum lectin (PPL) was molecularly characterized including molecular mas...
A computational model of cytosolic and mitochondrial [ca] in paced rat ventricular myocytes [0.03%]
大鼠心室肌细胞胞液和线粒体钙离子浓度的计算模型
Jae Boum Youm,Seong Woo Choi,Chang Han Jang et al.
Jae Boum Youm et al.
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca(2+) transients and compared the results with those from computer simulation. In rat ventricular myocytes, increasing the rate...
Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells [0.03%]
MAPK和PI3K信号通路调节血栓素诱导的C6胶质母细胞迁移和基质金属蛋白酶-9表达
Jiyoung Kim,Jae-Won Lee,Song-In Kim et al.
Jiyoung Kim et al.
Glioblastoma multiforme is one of the most common and aggressive tumors in central nervous system. It often possesses characteristic necrotic lesions with hemorrhages, which increase the chances of exposure to thrombin. Thrombin has been kn...
Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1 [0.03%]
西洛他唑通过血红素氧合酶-1诱导的腺苷酸活化蛋白激酶活化抑制血管平滑肌细胞增殖和活性氧生成
Jung Eun Kim,Jin Young Sung,Chang-Hoon Woo et al.
Jung Eun Kim et al.
Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cAMP levels and activates protein kinase A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated p...
Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes [0.03%]
槲皮素对爪蟾卵母细胞表达的烟碱型乙酰胆碱受体离子电流的影响
Byung-Hwan Lee,Tae-Joon Shin,Sung-Hee Hwang et al.
Byung-Hwan Lee et al.
The flavonoid quercetin is a low molecular weight compound generally found in apple, gingko, tomato, onion and other red-colored fruits and vegetables. Like other flavonoids, quercetin has diverse pharmacological actions. However, relativel...
Increased Expression of ATP-sensitive K Channels Improves the Right Ventricular Tolerance to Hypoxia in Rabbit Hearts [0.03%]
增高的ATP敏感性钾通道提高兔心室缺氧耐量
Seong Woo Choi,Jun Seok Ahn,Hyoung Kyu Kim et al.
Seong Woo Choi et al.
ATP-sensitive K(+) channels (K(ATP)) are major component of preventing ischemia-reperfusion injury. However, there is little information regarding to the expressional difference of K(ATP) and its function between left and right ventricles. ...
CD40 Co-stimulation Inhibits Sustained BCR-induced Ca Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells [0.03%]
CD40共刺激通过抑制BCR诱导的钙信号转导来阻断未成熟B细胞对长期抗原刺激的反应
Yen Hoang Nguyen,Ki-Young Lee,Tae Jin Kim et al.
Yen Hoang Nguyen et al.
Regulation of B cell receptor (BCR)-induced Ca(2+) signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature WEHI-231 cell...
Myoplasmic [ca], crossbridge phosphorylation and latch in rabbit bladder smooth muscle [0.03%]
家兔膀胱平滑肌中的肌质网钙释放、跨桥磷酸化和锁合现象
Young-Don Kim,Min-Hyung Cho,Seong-Chun Kwon
Young-Don Kim
TONIC SMOOTH MUSCLE EXHIBIT THE LATCH PHENOMENON: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and cellular activati...