3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells [0.03%]
3,4,5-三羟基肉桂酸通过抑制NF-κB活化来抑制LPS引起的iNOS表达BV2小胶质细胞中的作用研究
Jae-Won Lee,Chang Jun Bae,Yong-Jun Choi et al.
Jae-Won Lee et al.
Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as neuronal protection against excitotoxicity and anti-inflammatory property, the biological activity of 3,4,5-trihydrox...
Dongwoo Kang,Kyun-Seop Bae,Brett E Houk et al.
Dongwoo Kang et al.
The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not availabl...
Altered regulation of renal Acid base transporters in response to ammonium chloride loading in rats [0.03%]
氯化铵负荷下大鼠肾酸碱转运体调节的变化
Eun Young Kim,Joon Seok Choi,Ko Eun Lee et al.
Eun Young Kim et al.
The role of the kidney in combating metabolic acidosis has been a subject of considerable interest for many years. The present study was aimed to determine whether there is an altered regulation of renal acid base transporters in acute and ...
Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats [0.03%]
刺楸及其主要生物碱小檗碱改善草酸斯匹林诱导的大鼠神经元损伤和记忆功能障碍
Bombi Lee,Bongjun Sur,Insop Shim et al.
Bombi Lee et al.
We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory...
Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells [0.03%]
MI TFN1过表达导致胰岛素分泌细胞线粒体功能及动力缺陷
Kyu-Sang Park,Andreas Wiederkehr,Claes B Wollheim
Kyu-Sang Park
Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal β-cells. Adenoviru...
Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex [0.03%]
大鼠视觉皮层中五羟色胺在诱导长时程增强中的角色随年龄发生变化
Sung-Won Park,Hyun-Jong Jang,Kwang-Hyun Cho et al.
Sung-Won Park et al.
Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP and LTD during...
Requirement of Pretone by Thromboxane A(2) for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat [0.03%]
缺氧性肺血管收缩时TXA(2)对预先形成的 tone 的需求性研究
Su Jung Park,Hae Young Yoo,Hye Jin Kim et al.
Su Jung Park et al.
Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by throm...
Jong Mi Lee,Wi Joon Im,Yoon Jin Nam et al.
Jong Mi Lee et al.
It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT t...
Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation [0.03%]
胃激素通过抑制小胶质细胞活化保护脊髓运动神经元免受慢性谷氨酸毒性的损害
Sungyoub Lee,Yumi Kim,Endan Li et al.
Sungyoub Lee et al.
Glutamate excitotoxicity is emerging as a contributor to degeneration of spinal cord motoneurons in amyotrophic lateral sclerosis (ALS). Recently, we have reported that ghrelin protects motoneurons against chronic glutamate excitotoxicity t...
A novel pathway underlying the inhibitory effects of melatonin on isolated rat urinary bladder contraction [0.03%]
褪黑素抑制大鼠分离膀胱收缩的新机制研究
June Hyun Han,In Ho Chang,Soon Chul Myung et al.
June Hyun Han et al.
The aim of the present study was to elucidate the direct effects of melatonin on bladder activity and to determine the mechanisms responsible for the detrusor activity of melatonin in the isolated rat bladder. We evaluated the effects of me...