A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons [0.03%]
一类新的 carbamoyloxy arylalkanoyl arylpiperazine 类化合物（SKL-NP）通过抑制大鼠背根神经节神经元的_hyperpolarization-activated cyclic nucleotide-gated_(HCN)_通道电流发挥镇痛作用
Gehoon Chung,Tae-Hyung Kim,Hyewon Shin et al.
Gehoon Chung et al.
In this study, we determined mode of action of a novel carbamoyloxy arylalkanoyl arylpiperazine compound (SKL-NP) on hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents (I(h)) that plays important roles in neuropathic...
Effects of single treatment of anti-dementia drugs on sleep-wake patterns in rats [0.03%]
抗痴呆药物单次给药对大鼠睡眠觉醒模式的影响
Ji-Young Jung,Mootaek Roh,Kyung-Kyun Ko et al.
Ji-Young Jung et al.
We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the f...
Immunostimulatory Effects of β-glucan Purified from Paenibacillus polymyxa JB115 on Mouse Splenocytes [0.03%]
芽孢杆菌JB115来源的β-葡聚糖对小鼠脾细胞免疫刺激效应的研究
Ji-Mi Kim,Hong-Gu Joo
Ji-Mi Kim
We investigated the effects of β-glucan purified from Paenibacillus polymyxa JB115 on the viability and proliferation of splenocytes. Splenocytes play a critical role in host immunity. MTT assays and trypan blue exclusion tests revealed th...
Gap junction contributions to the goldfish electroretinogram at the photopic illumination level [0.03%]
缝隙连接对金鱼明视照明水平下视网膜电图的贡献
Doh-Yeon Kim,Chang-Sub Jung
Doh-Yeon Kim
Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave, we studied the contributions of gap jun...
Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons [0.03%]
NO通过cGMP/蛋白激酶G信号通路降低培养的大鼠背根神经节TRPV1阳离子通道活性
Yunju Jin,Jun Kim,Jiyeon Kwak
Yunju Jin
Recent studies have demonstrated that nitric oxide (NO) activates transient receptor potential vanilloid subtype 1 (TRPV1) via S-nitrosylation of the channel protein. NO also modulates various cellular functions via activation of the solubl...
Development of estimation methods of skin oxidation and evaluation of anti-oxidative effects of genistein in topical formulations [0.03%]
皮肤氧化评估方法的建立及大豆异黄酮体外抗氧化效果评价
Seong Yeon Kim,Yeon Joo Na,Dongju Kim et al.
Seong Yeon Kim et al.
The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formula...
Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells [0.03%]
tat介导的p66 shc转导降低了内皮细胞中内皮型一氧化氮合酶的磷酸化水平
Sang Ki Lee,Ji Young Lee,Hee Kyoung Joo et al.
Sang Ki Lee et al.
We evaluated the role of Tat-mediated p66shc transduction on the activation of endothelial nitric oxide synthase in cultured mouse endothelial cells. To construct the Tat-p66shc fusion protein, human full length p66shc cDNA was fused with t...
Proteomic analysis of colonic mucosal tissue from tuberculous and ulcerative colitis patients [0.03%]
结核性肠炎和溃疡性结肠炎患者的结肠黏膜组织蛋白质组分析
Seong-Chun Kwon,Kyung Jong Won,Seoung Hyo Jung et al.
Seong-Chun Kwon et al.
Changes in the expression profiles of specific proteins leads to serious human diseases, including colitis. The proteomic changes related to colitis and the differential expression between tuberculous (TC) and ulcerative colitis (UC) in col...
Hop extract produces antinociception by acting on opioid system in mice [0.03%]
hops提取物通过作用于小鼠的阿片受体系统产生镇痛作用
Soo-Hyun Park,Yun-Beom Sim,Yu-Jung Kang et al.
Soo-Hyun Park et al.
In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic a...
Reduction of Food Intake by Fenofibrate is Associated with Cholecystokinin Release in Long-Evans Tokushima Rats [0.03%]
非诺贝特通过促胰肽释放减少食物摄入量——对长岛延滨松系大鼠的研究
Mi-Kyoung Park,Ying Han,Mi Sun Kim et al.
Mi-Kyoung Park et al.
Fenofibrate is a selective peroxisome proliferator-activated receptor α (PPARα) activator and is prescribed to treat hyperlipidemia. The mechanism through which PPARα agonists reduce food intake, body weight, and adiposity remains unclea...