Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice [0.03%]
GAD65-eGFP小鼠下丘脑前区GABA能神经元的直接糖皮质激素调节作用研究
Seung Yub Shin,Tae Hee Han,So Yeong Lee et al.
Seung Yub Shin et al.
Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitor...
Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells [0.03%]
金丝桃苷通过上调PPAR-γ选择性抑制TNF-α活化的人内皮细胞VCAM-1但不是ICAM-1的表达
Jung Seok Hwa,Lidiya Mun,Hye Jung Kim et al.
Jung Seok Hwa et al.
Vascular inflammation process has been suggested to be an important risk factor in the development of atherosclerosis. Recently we reported that induction of peroxisome proliferator-activated receptor-γ (PPAR-γ) selectively inhibits vascu...
GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition [0.03%]
GS28在谷胱甘肽缺乏条件下保护过氧化氢诱导的神经元细胞死亡
Hwa Ok Lee,Yu Jeong Byun,Kyung-Ok Cho et al.
Hwa Ok Lee et al.
Golgi SNAP receptor complex 1 (GS28) has been implicated in vesicular transport between intra-Golgi networks and between endoplasmic reticulum (ER) and Golgi. Additional role(s) of GS28 within cells have not been well characterized. We obse...
The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder [0.03%]
α-防御素1对大鼠膀胱肾上腺素能反应的舒缓作用
Shin Young Lee,Don Kyu Kim,Kyung Do Kim et al.
Shin Young Lee et al.
Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of α-defensin 1 on detrusor muscle contractions ...
Influence of exposure to extremely low frequency magnetic field on neuroendocrine cells and hormones in stomach of rats [0.03%]
极低频电磁场暴露对大鼠胃神经内分泌细胞及激素的影响
Min Eui Hong,Kyu Hyun Yoon,Yoon Yang Jung et al.
Min Eui Hong et al.
Extremely low frequency magnetic fields (ELF-MF) have the ability to produce a variety of behavioral and physiological changes in animals. The stomach, as the most sensitive part of the neuroendocrine organ of the gastrointestinal tract, is...
5-hydroxytryptamine generates tonic inward currents on pacemaker activity of interstitial cells of cajal from mouse small intestine [0.03%]
5-羟色胺诱导的小肠间质细胞起搏电流离子机制研究
Pawan Kumar Shahi,Seok Choi,Dong Chuan Zuo et al.
Pawan Kumar Shahi et al.
In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions of 5-HT on pacemaker activities were investigat...
Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase [0.03%]
降压嗪乙酸提取物通过抑制鸟氨酸脱羧酶激活内皮衍生的一氧化氮合成酶
Woosung Shin,To Dao Cuong,Jeong Hyung Lee et al.
Woosung Shin et al.
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of C. sappan (CLE) showed inhibitory acti...
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice [0.03%]
基质金属蛋白酶抑制剂通过减轻神经炎症而发挥缺血性脑卒中的神经保护作用
Cheol Hong Park,Tae Kyeong Shin,Ho Youn Lee et al.
Cheol Hong Park et al.
The aim of this study was to investigate whether matrix metalloproteinase (MMP) inhibitors attenuate neuroinflammation in an ischemic brain following photothrombotic cortical ischemia in mice. Male C57BL/6 mice were anesthetized, and Rose B...
Suppression of autophagy and activation of glycogen synthase kinase 3beta facilitate the aggregate formation of tau [0.03%]
自噬抑制和糖原合酶激酶3β活化促进tau蛋白聚集形成
Song-In Kim,Won-Ki Lee,Sang-Soo Kang et al.
Song-In Kim et al.
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3β has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate the aggregate formation of tau. The prese...
Characterization and immunopotentiating effects of the glycoprotein isolated from dioscorea batatas [0.03%]
红皮芋螺蛋白多糖的免疫活性及作用机理研究
Pham Thi Thu Huong,Chan-Ho Lee,Mei Hong Li et al.
Pham Thi Thu Huong et al.
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly i...