Effects of hypothyroidism on cell proliferation and neuroblasts in the hippocampal dentate gyrus in a rat model of type 2 diabetes [0.03%]
实验糖尿病动物脑源性神经营养因子表达及亚临床甲状腺功能减退对其影响的研究进展
Sun Shin Yi,In Koo Hwang,Ji Won Choi et al.
Sun Shin Yi et al.
We observed how the hypothyroid state affects diabetic states and modifies cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (DG). For this, 0.03% methimazole, an anti-thyroid drug, was administered to 7-wee...
Hyongjong Koh,Jongkyeong Chung
Hyongjong Koh
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is characterized by movement disorders and a loss of dopaminergic (DA) neurons. PD mainly occurs sporadically, but may also result from genetic mutations in severa...
Seung-Hyuk Chung,Chul-Tae Kim,Young-Ho Jung et al.
Seung-Hyuk Chung et al.
Pax6, a paired homeobox DNA binding protein, has been found to be expressed in the cerebellum in both granule cells and their precursors in the external granular layer (EGL). In this study we have traced Pax6 expression through embryonic de...
Ji-Yeon Lee,Hyehyun Min,Xinnan Wang et al.
Ji-Yeon Lee et al.
Spatially and temporally programmed expression of the Hox genes along the antero-posterior (A-P) axis is essential for correct pattern formation during embryonic development. An accumulating body of evidence indicates the pivotal role of sp...
TBR2-immunopsitive unipolar brush cells are associated with ectopic zebrin II-immunoreactive Purkinje cell clusters in the cerebellum of scrambler mice [0.03%]
小脑突变体小鼠中与异位带状素II免疫反应性浦肯野细胞簇相关的TBR2免疫反应性单极刷细胞
Seung-Hyuk Chung,Chul-Tae Kim,Young-Gil Jeong et al.
Seung-Hyuk Chung et al.
Unipolar brush cells (UBCs) are excitatory interneurons with their somata located in the granular layer. Recently, T-brain factor 2 (Tbr2) was shown to be expressed in a subset of UBCs in mouse cerebellum. Scrambler mice exhibit severe cere...
Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebellum of the nNOS knock-out(-/-) mice [0.03%]
nNOS基因敲除小鼠小脑钙结合蛋白（Calbindin-D28k，Calretinin和Parvalbumin）的免疫组化研究
Jae Chul Lee,Yoon Hee Chung,Yu Jin Cho et al.
Jae Chul Lee et al.
Nitric Oxide (NO) actively participates in the regulation of neuronal intracellular Ca(2+) levels by modulating the activity of various channels and receptors. To test the possibility that modulation of Ca(2+) buffer protein expression leve...
Effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 immunoreactivity and protein levels in the gerbil hippocampus after transient cerebral ischemia [0.03%]
反复束缚应激对短趾田鼠海马区脑缺血后血管细胞粘附分子-1免疫反应性和蛋白质水平的影响
Ok Kyu Park,Choong Hyun Lee,In Koo Hwang et al.
Ok Kyu Park et al.
Stress has long been known to be a causative factor of various disease states. In this study, we investigated the effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 (PECAM-1), a very important mediator in ...
Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia [0.03%]
一氧化氮前体_agmatine对短暂性脑缺血后脾脏变化的影响研究
D Uranchimeg,Jae Hwan Kim,Jae Young Kim et al.
D Uranchimeg et al.
Stroke or cerebrovascular injury is the leading cause of disability and the third leading cause of deaths worldwide. After the initial ischemic injury, sympathetic signals are transmitted to the spleen and a compromised blood-brain barrier,...
Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation [0.03%]
姜黄素抑制被动皮肤过敏反应和化合物48/80诱导的肥大细胞活化的作用
Yun-Ho Choi,Guang-Hai Yan,Ok Hee Chai et al.
Yun-Ho Choi et al.
Mast cells participate in allergies and inflammation by secreting a variety of pro-inflammatory mediators. Curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative, and a...
Vitamin C acts indirectly to modulate isotype switching in mouse B cells [0.03%]
维生素C通过间接作用调节小鼠B细胞的同种型转换
Ami Woo,Jin-Hee Kim,Young-Joo Jeong et al.
Ami Woo et al.
Vitamin C, one of essential micronutrients, has been reported to modulate the humoral immune responses in some mammals. We investigated whether vitamin C might modulate this response in mice by directly affecting B cells. Splenic B cells we...