Jin-Seok Byun,Won-Il Jeong
Jin-Seok Byun
Excessive alcohol consumption is one of the critical causative factors leading to alcoholic liver disease (ALD). ALD is characterized by a wide spectrum of liver damage, ranging from simple uncomplicated liver steatosis (fatty liver) to ste...
Cell to Cell Interaction Can Activate Membrane-bound APRIL Which Are Expressed on Inflammatory Macrophages [0.03%]
炎症巨噬细胞所表达的膜型APRIL可以通过细胞间的相互作用被活化
Sang-Min Lee,Won-Jung Kim,Kyoungho Suk et al.
Sang-Min Lee et al.
Background: APRIL, originally known as a cytokine involved in B cell survival, is now known to regulate the inflammatory activation of macrophages. Although the signal initiated from APRIL has been demonstrated, its role ...
Association of Intracellular T(H)1-T(H)2 Balance in CD4+ T-cells and MIP-1α in CD8+ T-cells with Disease Severity in Adults with Dengue [0.03%]
成人登革热患者细胞内T(H)1/T(H)2平衡及CD4+T细胞、CD8+T细胞中MIP-1α与登革热严重程度的关系
Tamilarasu Kadhiravan,Ankit Saxena,Amar Singh et al.
Tamilarasu Kadhiravan et al.
Background: We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a T(H)1-skewed immune response as opposed to dengue fever (DF). ...
CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells [0.03%]
由IL-12信号调控的CD43表达与CD8 T细胞生存相关性研究
Jee-Boong Lee,Jun Chang
Jee-Boong Lee
Background: In addition to TCR and costimulatory signals, cytokine signals are required for the differentiation of activated CD8 T cells into memory T cells and their survival. Previously, we have shown that IL-12 priming...
Jeon Hyeun Choi,Young Na Park,Ying Li et al.
Jeon Hyeun Choi et al.
Background: The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for the treatment of inflammatory diseases. In the present study, we investigated the anti-inflammatory properties of Inu...
Cordyceps militaris Enhances MHC-restricted Antigen Presentation via the Induced Expression of MHC Molecules and Production of Cytokines [0.03%]
虫草素通过诱导MHC分子表达和细胞因子产生增强MHC限制性抗原呈递作用
Seulmee Shin,Yoonhee Park,Seulah Kim et al.
Seulmee Shin et al.
Background: Cordyceps militarys water extract (CME) has been reported to exert antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not yet been elucidated. In this study,...
Expression of hepatitis B virus x protein in hepatocytes suppresses CD8 T cell activity [0.03%]
乙型肝炎病毒X蛋白表达通过抑制CD8T细胞活性促进慢性感染
Mi Jin Lee,Young-Hee Jin,Kyongmin Kim et al.
Mi Jin Lee et al.
Background: CD8(+) T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8(+) T cell response may be one of the major factors leading to chronic HBV infection. Since the HBx antige...
T-cell dysfunction and inhibitory receptors in hepatitis C virus infection [0.03%]
丙型肝炎病毒感染中的T细胞功能障碍和抑制受体
Jino Lee,William I Suh,Eui-Cheol Shin
Jino Lee
Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional CD8 T cells often overexpress vario...
Heterogeneity of IL-22-producing Lymphoid Tissue Inducer-like Cells in Human and Mouse [0.03%]
人和鼠中产生IL-22的淋巴组织诱导物样细胞的异质性
Soochan Kim,Sinsuk Han,Mi-Yeon Kim
Soochan Kim
Lymphoid tissue inducer (LTi) cells have been characterized in mouse as a key cell when secondary lymphoid tissues are organized during development and memory T cells are formed after birth. In addition to their involvement in adaptive immu...
Role of th17 cell and autoimmunity in chronic obstructive pulmonary disease [0.03%]
Th17细胞和自身免疫在慢性阻塞性肺疾病中的作用
Seok Chan Hong,Seung-Hyo Lee
Seok Chan Hong
The molecular mechanisms involved in the pathogenesis of chronic obstructive pulmonary disease (COPD) are poorly defined. Accumulating evidences indicate that chronic inflammatory responses and adaptive immunity play important roles in the ...