The Role of MicroRNAs in Regulatory T Cells and in the Immune Response [0.03%]
microRNA在调节性T细胞和免疫反应中的作用
Tai-You Ha
Tai-You Ha
The discovery of microRNA (miRNA) is one of the major scientific breakthroughs in recent years and has revolutionized current cell biology and medical science. miRNAs are small (19~25nt) noncoding RNA molecules that post-transcriptionally r...
Grace Yoonhee Kim,Changwan Hong,Jung-Hyun Park
Grace Yoonhee Kim
Interleukin-7 (IL-7) is an essential cytokine for T cells. However, IL-7 is not produced by T cells themselves such that T cells are dependent on extrinsic IL-7. In fact, in the absence of IL-7, T cell development in the thymus as well as s...
Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg) [0.03%]
人外周血单个核细胞中存在表达Foxp3的CD19+CD5+B细胞：人CD19+CD5+Foxp3+Breg细胞的存在
Joonyong Noh,Wahn Soo Choi,Geunwoong Noh et al.
Joonyong Noh et al.
Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing ...
Characterization of a Novel Monoclonal Antibody (27H2) Recognizing Human CD34 Class III Epitope [0.03%]
人源CD34类三型表位识别单克隆抗体27H2的鉴定
Kwon Pyo Hong,Sung Hee Kang,Kyoung-Mee Lee et al.
Kwon Pyo Hong et al.
Background: Monoclonal antibodies (mAbs) recognizing Class III epitope of CD34 are essential for flow cytometric diagnosis of leukemia. Methods: ...
Activation of Macrophages by Exopolysaccharide Produced by MK1 Bacterial Strain Isolated from Neungee Mushroom, Sarcodon aspratus [0.03%]
来源于松茸的枯鲁菌株MK1胞外多糖激活巨噬细胞的作用研究
Sun-A Im,Wenxia Wang,Chong-Kil Lee et al.
Sun-A Im et al.
Background: The MK1 strain, a novel bacterial isolate from soft-rotten tissue of the Neungee mushroom, produces copious amounts of exopolysaccharide (EPS) in a dextrose minimal medium. This study examined the molecular ch...
NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production [0.03%]
NDRG2通过调控SOCS3和STAT3活性抑制IL-10产生作用机制研究
Eun Byul Lee,Aeyung Kim,Kyeongah Kang et al.
Eun Byul Lee et al.
Background: N-myc downstream regulated gene 2 (NDRG2) is a member of the NDRG gene family. Our previous report indicated a possible role for NDRG2 in regulating the cytokine, interleukin-10 (IL-10), which is an important ...
The Stem Bark of Kalopanax pictus Exhibits Anti-inflammatory Effect through Heme Oxygenase-1 Induction and NF-κB Suppression [0.03%]
石梓茎皮的抗炎作用通过血红素氧合酶-1诱导和核因子-κB抑制实现
Soo Young Bang,Ga-Young Park,Sun Young Park et al.
Soo Young Bang et al.
Background: The stem bark of Kalopanax pictus (KP) has been used in traditional medicine to treat rheumatoidal arthritis, neurotic pain and diabetes mellitus in China and Korea. In this study, the mechanism responsible fo...
Induction of 90K-specific Cytotoxic T Lymphocytes for Colon Cancer Immunotherapy [0.03%]
诱导针对结直肠癌免疫治疗的90K特异性细胞毒性T淋巴细胞
Ji Hee Lee,Myung Suk Park,Ik Joo Chung
Ji Hee Lee
Background: Dendritic cell (DC)-based tumor vaccine is an attractive modality for the treatment of colon cancer because it has been recurred and produced few side effects in patients. Secretory glycoprotein 90K has been f...
Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys [0.03%]
IL-7联合多基因型DNA疫苗诱导的丙型肝炎病毒抗体及广谱T细胞应答增强作用研究
Su-Hyung Park,Mi-Young Song,Hyo Jung Nam et al.
Su-Hyung Park et al.
Background: A crucial limitation of DNA vaccines is its weak immunogenicity, especially in terms of eliciting antibody responses in non-human primates or humans; therefore, it is essential to enhance immune responses to v...
Hyung Sook Kim,Jee Youn Kim,Hong Kyung Lee et al.
Hyung Sook Kim et al.
Background: Lichen-derived glucans have been known to stimulate the functions of immune cells. However, immunostimulatory activity of glucan obtained from edible lichen, Umbilicaria esculenta, has not been reported. Thus ...