Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways [0.03%]
鸟分枝杆菌的硫酸软骨素黏附素激活炎症反应的研究
Ki-Hye Kim,Chul-Su Yang,A-Rum Shin et al.
Ki-Hye Kim et al.
Background: Mycobacterium tuberculosis (Mtb) heparin binding hemagglutinin (HBHA) is an Ag known to evoke effective host immune responses during tuberculosis infection. However, the molecular basis of the host immune resp...
Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45) [0.03%]
人白细胞共同抗原(CD45)单克隆抗体的鉴定研究
Hyang-Mi Shin,Woon-Dong Cho,Geon-Kook Lee et al.
Hyang-Mi Shin et al.
Background: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. Methods: W...
Dietary Aloe Reduces Adipogenesis via the Activation of AMPK and Suppresses Obesity-related Inflammation in Obese Mice [0.03%]
膳食芦荟通过激活AMPK减少肥胖小鼠的脂肪生成及相关的炎症反应
Eunju Shin,Seulmee Shin,Hyunseok Kong et al.
Eunju Shin et al.
Background: Metabolic disorders, including type II diabetes and obesity, present major health risks in industrialized countries. AMP-activated protein kinase (AMPK) has become the focus of a great deal of attention as a n...
Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen [0.03%]
单抗原H-2d等位基因特异的CTL克隆对小鼠次要组织相容性抗原H-60的反应特征研究
Ji Yeong Jeon,Kyung Min Jung,Jun Chang et al.
Ji Yeong Jeon et al.
Background: Disparities of Minor H antigens can induce graft rejection after MHC-matched transplantation. H60 has been characterized as a dominant antigen expressed on hematopoietic cells and considered to be an ideal mod...
Role of innate immunity in diabetes and metabolism: recent progress in the study of inflammasomes [0.03%]
固有免疫在糖尿病和代谢中的作用：炎性体研究的新进展
Myung-Shik Lee
Myung-Shik Lee
Type 1 diabetes is one of the classical examples of organ- specific autoimmune diseases characterized by lymphocytic infiltration or inflammation in pancreatic islets called 'insulitis'. In contrast, type 2 diabetes has been traditionally r...
Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine [0.03%]
去 podophyllotoxin诱导Th1反应并增强基于树突状细胞的疫苗的抗肿瘤疗效
Jun Sik Lee,Dae Hyun Kim,Chang-Min Lee et al.
Jun Sik Lee et al.
Background: Dendritic cell (DC)-based vaccines are currently being evaluated as a novel strategy for tumor vaccination and immunotherapy. However, inducing long-term regression in established tumor-implanted mice is diffi...
Effects of Pre-conditioning Dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissues after MHC-matched Transplantation [0.03%]
主要组织相容性复合体全合移植后供者淋巴细胞回输 preconditioning剂量对移植物抗宿主病组织浸润的免疫动力学和细胞因子产生的影响
Jung Hwa Choi,Hyewon Yoon,Chang-Ki Min et al.
Jung Hwa Choi et al.
Background: Graft-versus-host disease (GVHD) is a huddle for success of hematopoietic stem cell transplantation. In this study, effects of irradiation dose on immune kinetics of GVHD were investigated using B6 → BALB.B s...
Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice [0.03%]
口服芦荟多糖通过抑制肥胖诱导的炎症改善小鼠胰岛素抵抗
Eunju Shin,Kyu-Suk Shim,Hyunseok Kong et al.
Eunju Shin et al.
Background: Insulin resistance is an integral feature of metabolic syndromes, including obesity, hyperglycemia, and hyperlipidemia. In this study, we evaluated whether the aloe component could reduce obesity-induced infla...
Expression of Epstein-Barr Virus Gene and Clonality of Infiltrated T Lymphocytes in Epstein-Barr Virus-associated Gastric Carcinoma [0.03%]
EB病毒基因表达及侵润T淋巴细胞克隆性在EB病毒相关胃癌中的研究
Jae Myun Lee,Hoguen Kim,Sung Hoon Noh et al.
Jae Myun Lee et al.
Background: Epstein-Barr virus associated gastric lymphoepithelioma-like carcinoma (LELC) is characterized by the intensive infiltration of lymphoid cells, the presence of EBV, and the better prognosis over typical adenoc...
Anti-inflammatory and Anti-oxidative Effects of Korean Red Ginseng Extract in Human Keratinocytes [0.03%]
韩国红人参提取物的抗炎和抗氧化作用的人表皮黑素细胞研究
Chang-Eui Hong,Su-Yun Lyu
Chang-Eui Hong
Background: In this study, we have investigated the effect of Korean red ginseng (KRG) extracts on the production of TNF-α and IL-8 in human keratinocytes. Also, to examine the antioxidative effect of red ginseng extract...