The Anti-tumor Activity of Vitamin C via the Increase of Fas (CD95) and MHC I Expression on Human Stomach Cancer Cell Line, SNU1 [0.03%]
维生素C通过上调Fas(CD95)和MHC I的表达在人胃癌细胞系SNU1中发挥抗肿瘤作用
Yeonsil Yu,Seyeon Bae,Hyemin Kim et al.
Yeonsil Yu et al.
Background: It is already known that high concentration of vitamin C induces apoptosis on tumor cells. However, there is no report regarding the function of vitamin C on the modulation of immune susceptibility of cancer. ...
Identification of CCL1 as a Gene Differentially Expressed in CD4 T Cells Expressing TIM-3 [0.03%]
识别出CCL1是TIM-3阳性CD4 T细胞差异表达基因
Ka Jung Jun,Mi Jin Lee,Dong Chul Shin et al.
Ka Jung Jun et al.
Background: T cell immunoglobulin mucin containing molecule (TIM)-3 is expressed in differentiated Th1 cells and is involved in the suppression of the cytokine production by these cells. However, the regulation of the exp...
Activin A Stimulates Mouse APCs to Express BAFF via ALK4-Smad3 Pathway [0.03%]
活化素A通过ALK4-Smad3通路促进小鼠APC细胞表达BAFF
Jae-Hee Kim,Goo-Young Seo,Pyeung-Hyeun Kim
Jae-Hee Kim
Background: B cell-activating factor belonging to the TNF family (BAFF) is primarily expressed by macrophages and dendritic cells, and stimulates B cell proliferation, differentiation, survival, and Ig production. In the ...
Hyung Sook Kim,Jin Tae Hong,Youngsoo Kim et al.
Hyung Sook Kim et al.
β-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well stu...
Enhanced Induction of T Cell Immunity Using Dendritic Cells Pulsed with HIV Tat and HCMV-pp65 Fusion Protein In Vitro [0.03%]
体外使用融合了HIV-Tat和HCMV-pp65蛋白的树突状细胞增强T淋巴细胞免疫诱导功能的研究
Jung-Sun Park,Soo-Young Park,Hyun-Il Cho et al.
Jung-Sun Park et al.
Background: Cytotoxic T lymphocytes (CTLs) appear to play an important role in the control and prevention of human cytomegalovirus (HCMV) infection. The pp65 antigen is a structural protein, which has been defined as a po...
Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer [0.03%]
CM1在炎症性疾病和癌症中的致病作用及其机制研究
Seyeon Bae,Hyemin Kim,Yeon Sil Yu et al.
Seyeon Bae et al.
Background: CM1 (centrocyte/-blast marker 1) was defined by a mAb against concanavalin A (Con A) activated PBMC. It is expressed in germinal center of human tonsil and on the surface of activated PBMC as well as cancer ce...
Hee Yeon Won,Eun Jung Jang,Hyun Jung Min et al.
Hee Yeon Won et al.
Background: NADPH oxidase (NOX) modulates cell proliferation, differentiation and immune response through generation of reactive oxygen species. Particularly, NOX2 is recently reported to be important for regulating Treg ...
Formulation and Characterization of Antigen-loaded PLGA Nanoparticles for Efficient Cross-priming of the Antigen [0.03%]
高效交叉引发抗原的载有抗原的PLGA纳米颗粒的制备及表征
Young-Ran Lee,Young-Hee Lee,Sun-A Im et al.
Young-Ran Lee et al.
Background: Nanoparticles (NPs) prepared from biodegradable polymers, such as poly (D,L-lactic acid-co-glycolic acid) (PLGA), have been studied as vehicles for the delivery of antigens to phagocytes. This paper describes ...
Eun-Jeong Yang,Jin-Won Seo,In-Hong Choi
Eun-Jeong Yang
Background: Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA) and induces inflammation. In this study we attempted to ascertain if there are endogenous host molecules controlling the production of cytokin...
Tai-You Ha
Tai-You Ha
The great discovery of microRNAs (miRNAs) has revolutionized current cell biology and medical science. miRNAs are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3' untranslated...