Deficiency of foxp3 regulatory T cells exacerbates autoimmune arthritis by altering the synovial proportions of CD4 T cells and dendritic cells [0.03%]
Foxp3调节性T细胞缺乏通过改变滑膜CD4 T细胞和树突状细胞的比例加重自身免疫性关节炎
Eunkyeong Jang,Mi La Cho,Hye-Joa Oh et al.
Eunkyeong Jang et al.
Background: CD4(+)Fop3(+) regulatory T cells (Tregs) are needed to maintain peripheral tolerance, but their role in the development of autoimmune arthritis is still debated. The present study was undertaken to investigate...
Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation [0.03%]
丹参调节Th2源性细胞因子在抗炎中的作用
Sunhee Moon,Seulmee Shin,Seulah Kim et al.
Sunhee Moon et al.
Background: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. ...
Nanoliposomes of L-lysine-conjugated poly(aspartic acid) Increase the Generation and Function of Bone Marrow-derived Dendritic Cells [0.03%]
L-赖氨酸连接聚天冬氨酸纳米脂质体促进骨髓来源树突状细胞的生成及其功能增强
Sun-A Im,Ki-Hyang Kim,Hong-Geun Ji et al.
Sun-A Im et al.
Background: Biodegradable polymers have increasingly been recognized for various biological applications in recent years. Here we examined the immunostimulatory activities of the novel poly(aspartic acid) conjugated with ...
Distinct Humoral and Cellular Immunity Induced by Alternating Prime-boost Vaccination Using Plasmid DNA and Live Viral Vector Vaccines Expressing the E Protein of Dengue Virus Type 2 [0.03%]
表达登革热病毒2型E蛋白的质粒DNA和活病毒载体疫苗交替免疫诱导不同的体液及细胞免疫反应
Junu A George,Seong Kug Eo
Junu A George
Background: Dengue virus, which belongs to the Flavivirus genus of the Flaviviridae family, causes fatal dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) with infection risk of 2.5 billion people worldwide. ...
Gene Expression Profile of T-cell Receptors in the Synovium, Peripheral Blood, and Thymus during the Initial Phase of Collagen-induced Arthritis [0.03%]
胶原诱导性关节炎起病初期滑膜、外周血和胸腺中T细胞受体基因表达谱分析
Ji-Young Kim,Mi Kyoung Lim,Dong Hyuk Sheen et al.
Ji-Young Kim et al.
Background: Current management strategies attempt to diagnose rheumatoid arthritis (RA) at an early stage. Transcription profiling is applied in the search for biomarkers for detecting early-stage disease. Even though gen...
Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis [0.03%]
韩国结核病患者体内维生素D受体基因TaqI、BsmI和FokI多态性分析
Tae Jin Kang,Song Hou Jin,Chung-Eun Yeum et al.
Tae Jin Kang et al.
Background: The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. ...
Dong-Min Shin,Eun-Kyeong Jo
Dong-Min Shin
Antimicrobial peptides/proteins are ancient and naturallyoccurring antibiotics in innate immune responses in a variety of organisms. Additionally, these peptides have been recognized as important signaling molecules in regulation of both in...
MicroRNAs in Human Diseases: From Autoimmune Diseases to Skin, Psychiatric and Neurodegenerative Diseases [0.03%]
人类疾病的微小核糖核酸：从自身免疫疾病到皮肤、精神病和神经退行性疾病
Tai-You Ha
Tai-You Ha
MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play crit...
IGF-I Exerts an Anti-inflammatory Effect on Skeletal Muscle Cells through Down-regulation of TLR4 Signaling [0.03%]
胰岛素样生长因子IGF-I通过下调TLR4信号通路发挥抗炎效应
Won Jun Lee
Won Jun Lee
Although exercise-induced growth factors such as Insulin-like growth factor-I (IGF-I) are known to affect various aspects of physiology in skeletal muscle cells, the molecular mechanism by which IGF-I modulates anti-inflammatory effects in ...
Recombinant TAT-CD137 Ligand Cytoplasmic Domain Fusion Protein Induces the Production of IL-6 and TNF-α in Peritoneal Macrophages [0.03%]
重组TAT-CD137胞质区融合蛋白诱导腹腔巨噬细胞产生IL-6和TNF-α
Jung Dae Kim,Eun Ah Lee,Nguyen N Quang et al.
Jung Dae Kim et al.
Background: The ligand for CD137 (CD137L; also called 4-1BBL) is mainly expressed on activated APCs such as dendritic cells, B cells and macrophages. Even though CD137L functions as a trigger of the CD137 signaling pathwa...