Cellular Mechanism of Newly Synthesized Indoledione Derivative-induced Immunological Death of Tumor Cell [0.03%]
新合成的吲哚二酮衍生物诱导肿瘤细胞免疫性死亡的细胞机制研究
Su-Jin Oh,Chung-Kyu Ryu,So-Young Baek et al.
Su-Jin Oh et al.
Background: EY-6 is one of the newly synthesized indoledione derivatives to induce tumor cell-specific cell death. In this study, we investigated the mechanism of immunological death induced by EY-6 at mouse colon cancer ...
Hyo Jeong Kim,Min Zheng,Seul-Ki Kim et al.
Hyo Jeong Kim et al.
Background: Carbon monoxide (CO) is a cytoprotective and homeostatic molecule with important signaling capabilities in physiological and pathophysiological situations. CO protects cells/tissues from damage by free radical...
Blockade of Vascular Endothelial Growth Factor (VEGF) Aggravates the Severity of Acute Graft-versus-host Disease (GVHD) after Experimental Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) [0.03%]
血管内皮生长因子(VEGF)的阻断可加剧实验性异基因造血干细胞移植(allo-HSCT)后急性移植物抗宿主病(GVHD)的严重程度
Ai-Ran Kim,Ji-Young Lim,Dae Chul Jeong et al.
Ai-Ran Kim et al.
Background: Recent clinical observation reported that there was a significant correlation between change in circulating vascular endothelial growth factor (VEGF) levels and the occurrence of severe acute graft-versus-host...
Production of prostaglandin e(2) and i(2) is coupled with cyclooxygenase-2 in human follicular dendritic cells [0.03%]
人卵泡树突细胞中的前列腺素e（2）和i（2）的生成与环氧化酶-2相关联
Whajung Cho,Jini Kim,Kyu-Bong Cho et al.
Whajung Cho et al.
Background: Prostaglandins (PGs) play pathogenic and protective roles in inflammatory diseases. The novel concept of PGs as immune modulators is being documented by several investigators. By establishing an in vitro exper...
Influence of Interferon-γ Deficiency in Immune Tolerance Induced by Male Islet Transplantation [0.03%]
干扰素-γ缺乏对诱导同种异体胰岛移植免疫耐受的影响
Yong-Hee Kim,Youngkyoung Lim,Chung-Gyu Park
Yong-Hee Kim
Background: Traditionally, interferon-γ (IFN-γ) was regarded as a pro-inflammatory cytokine, however, recent reports suggested role of IFN-γ in immune tolerance. In our previous report, we could induce tolerance to mal...
NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells [0.03%]
NDRG2通过调节jak2/stat途径促进PMA诱导的U937细胞中GATA-1的表达
Kyeongah Kang,Hyeyoun Jung,Sorim Nam et al.
Kyeongah Kang et al.
Background: N-myc downstream-regulated gene 2 (NDRG2), a member of a newly described family of differentiation-related genes, has been characterized as a regulator of dendritic cells. However, the role of NDRG2 on the exp...
Modulation of glial and neuronal migration by lipocalin-2 in zebrafish [0.03%]
脂联素-2在斑马鱼中对胶质细胞和神经元迁移的调节作用
Ho Kim,Shinrye Lee,Hae-Chul Park et al.
Ho Kim et al.
Background: Glial cells are involved in immune and inflammatory responses in the central nervous system (CNS). Glial cells such as microglia and astrocytes also provide structural and functional support for neurons. Migra...
T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells [0.03%]
调节胸腺内天然调节性T细胞发育的T细胞受体信号转导
Ki-Duk Song,Sujin Hwang,Cheol-Heui Yun
Ki-Duk Song
T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to p...
Stephen Ahn,Hee-Back Choi,Tai-Gyu Kim
Stephen Ahn
The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function....
MicroRNAs in Human Diseases: From Lung, Liver and Kidney Diseases to Infectious Disease, Sickle Cell Disease and Endometrium Disease [0.03%]
人类疾病的微小核糖核酸：从肺、肝和肾疾病到传染病、镰状细胞病及子宫内膜病
Tai-You Ha
Tai-You Ha
MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs of about 22 nucleotides that have recently emerged as important regulators of gene expression at the posttranscriptional level. Recent studies provided clear eviden...