Baculovirus-based Vaccine Displaying Respiratory Syncytial Virus Glycoprotein Induces Protective Immunity against RSV Infection without Vaccine-Enhanced Disease [0.03%]
一种呼吸道合胞病毒糖蛋白展示杆状病毒疫苗可免受呼吸合胞病毒感染且不会增强疾病
Sol Kim,Jun Chang
Sol Kim
Background: Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract diseases in infancy and early childhood. Despite its importance as a pathogen, there is no licensed vaccine against RSV yet....
Anupama Sahoo,Sin-Hyeog Im
Anupama Sahoo
Interleukin-24 (IL-24) belongs to the IL-10 family of cytokines and is well known for its tumor suppressor activity. This cytokine is released by both immune and nonimmune cells and acts on non-hematopoietic tissues such as skin, lung and r...
Anti-CD137 mAb Deletes Both Donor CD4 and CD8 T Cells in Acute Graft-versus-host Disease [0.03%]
抗CD137单抗在急性移植物抗宿主病中清除供者CD4和CD8T细胞作用机制研究
Juyang Kim,Hong Rae Cho,Byungsuk Kwon
Juyang Kim
We previously demonstrated that in vivo engagement of CD137, a member of TNF receptor superfamily, can delete allorective CD4(+) T cells through the induction of activation-induced cell death (AICD) in chronic graft-versus-host disease (cGV...
The Role of Intracellular Receptor NODs for Cytokine Production by Macrophages Infected with Mycobacterium leprae [0.03%]
NODs胞内受体在麻风分枝杆菌感染的巨噬细胞中产生细胞因子的作用机制研究
Tae Jin Kang,Gue-Tae Chae
Tae Jin Kang
The nucleotide-oligomerization domain (NOD) proteins are members of the NOD-like receptor (NLR) family, which are intracellular and cytoplasmic receptors. We analyzed the role of NODs for cytokine production by macrophages infected with int...
CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling [0.03%]
CKD-712，(S)-1-(α-萘基甲基)-6,7-二羟基-1,2,3,4-四氢异喹啉通过下调TLR4信号通路中的NF-κB发挥促Akt激活作用
Jeonggi Lee,Eun-Jeong Yang,Jeon-Soo Shin et al.
Jeonggi Lee et al.
Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS stimulation. Activation of NF-κB was asses...
Th17 responses are not induced in dextran sodium sulfate model of acute colitis [0.03%]
葡聚糖硫酸钠诱导的急性结肠炎模型中不产生TH17应答
Yoon Suk Kim,Min Ho Lee,Ahn Seung Ju et al.
Yoon Suk Kim et al.
Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD. Recent studies suggest that the acute DSS-colitis model is...
Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing [0.03%]
化合物Hypocrellin A免疫调节作用机制的研究
Sunim Park,Sun-A Im,Ki-Hyang Kim et al.
Sunim Park et al.
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hy...
Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA) [0.03%]
利用基因集富集分析（GSEA）比较不变自然杀伤T细胞与常规T细胞的区别
Sae Jin Oh,Ji Ye Ahn,Doo Hyun Chung
Sae Jin Oh
Background: Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant Vαβ TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with convention...
Maturation-resistant dendritic cells ameliorate experimental autoimmune uveoretinitis [0.03%]
成熟抵抗型树突状细胞改善实验性自身免疫性葡萄膜炎
Keunhee Oh,Yon Su Kim,Dong-Sup Lee
Keunhee Oh
Background: Endogenous uveitis is a chronic inflammatory eye disease of human, which frequently leads to blindness. Experimental autoimmune uveoretinitis (EAU) is an animal disease model of human endogenous uveitis and ca...
Cross-linking of CD80 and CD86 Diminishes Expression of CD54 on EBV-transformed B Cells through Inactivation of RhoA and Ras [0.03%]
CD80和CD86的交联通过RhoA和Ras的失活抑制EB病毒转化的B细胞表面CD54分子表达
Ga Bin Park,Yeong Seok Kim,Hyunkeun Song et al.
Ga Bin Park et al.
Background: Epstein Barr virus (EBV) infected B cells are transformed into lymphoblastoid cell lines. Some researchers suggested some a few similarities between this process and carcinogenesis. We observed the expression ...