Kinetic Analysis of CpG-Induced Mouse B Cell Growth and Ig Production [0.03%]
基于CpG诱导的小鼠B细胞增殖及其抗体产生动力学分析研究
Young-Ha Kim,Sang-Hoon Lee,Yung-Choon Yoo et al.
Young-Ha Kim et al.
Immune cells express toll-like receptors (TLRs) and respond to molecular patterns of various pathogens. CpG motif in bacterial DNA activates innate and acquired immune systems through binding to TLR9 of immune cells. Several studies reporte...
Lactoferrin Stimulates Mouse Macrophage to Express BAFF via Smad3 Pathway [0.03%]
乳铁蛋白通过Smad3信号途径刺激小鼠巨噬细胞表达BAFF
Heynkeyung Chang,Bo-Ra Jin,Young-Saeng Jang et al.
Heynkeyung Chang et al.
B cell-activating factor belonging to the TNF family (BAFF) is primarily expressed by macrophages and stimulates B cell proliferation, differentiation, survival, and Ig production. In this study, we explored the effect of lactoferrin (LF) o...
Indre Piragyte,Chang-Duk Jun
Indre Piragyte
T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediat...
Chemotherapeutic candidate inducing immunological death of human tumor cell lines [0.03%]
诱导人类肿瘤细胞系免疫性死亡的化疗候选项
Su-Jin Oh,Chung-Kyu Ryu,Inhak Choi et al.
Su-Jin Oh et al.
The immunological death induction by EY-6 on the human tumor cell lines was screened. Human colon carcinoma (HCT15, HCT116), gastric carcinoma (MKN74, SNU668), and myeloma (KMS20, KMS26, KMS34) cells were died by EY-6 treatment with dose-de...
Reactivation of Silenced WT1 Transgene by Hypomethylating Agents - Implications for in vitro Modeling of Chemoimmunotherapy [0.03%]
DNA低甲基化药物活化WT1转基因小鼠的沉默基因：对体外建立白血病化疗免疫治疗模型的意义
Yong-Rim Kwon,Min-Jung Son,Hye-Jung Kim et al.
Yong-Rim Kwon et al.
Background: A cell line with transfected Wilms' tumor protein 1 (WT1) is has been used for the preclinical evaluation of novel treatment strategies of WT1 immunotherapy for leukemia due to the lack of appropriate murine l...
The Roles and Perspectives of Toll-Like Receptors and CD4(+) Helper T Cell Subsets in Acute Viral Encephalitis [0.03%]
toll样受体和CD4⁺辅助T细胞亚群在急性病毒性脑炎中的作用和视角
Young Woo Han,Sunit K Singh,Seong Kug Eo
Young Woo Han
Acute viral encephalitis caused by neurotrophic viruses, such as mosquito-borne flaviviruses, is an emerging and re-emerging disease that represents an immense global health problem. Considerable progression has been made in understanding t...
Mithilesh Kumar Jha,Sangmin Jeon,Kyoungho Suk
Mithilesh Kumar Jha
Contemporary studies illustrate that peripheral injuries activate glial components of the peripheral and central cellular circuitry. The subsequent release of glial stressors or activating signals contributes to neuropathic pain and neuroin...
Jeong-Won Hong,Woon-Dong Cho,Kwon Pyo Hong et al.
Jeong-Won Hong et al.
Background: Therapeutic approaches using monoclonal antibodies (mAbs) against complement regulatory proteins (CRPs:i.e.,CD46,CD55 and CD59) have been reported for adjuvant cancer therapy. In this study, we generated a rec...
Newly Identified TLR9 Stimulant, M6-395 Is a Potent Polyclonal Activator for Murine B Cells [0.03%]
新型TLR9刺激剂M6-395是小鼠B细胞的强力多克隆激活剂
Mi-Hee Park,Yu-Jin Jung,Pyeung-Hyeun Kim
Mi-Hee Park
Background: Toll-like receptors (TLRs) have been extensively studied in recent years. However, functions of these molecules in murine B cell biology are largely unknown. A TLR4 stimulant, LPS is well known as a powerful p...
The analysis of vitamin C concentration in organs of gulo(-/-) mice upon vitamin C withdrawal [0.03%]
维生素C缺乏对gulo(-/-)小鼠器官中维生素C浓度的影响分析
Hyemin Kim,Seyeon Bae,Yeonsil Yu et al.
Hyemin Kim et al.
Background: Vitamin C is an essential nutrient for maintaining human life. Vitamin C insufficiency in the plasma is closely related with the development of scurvy. However, in vivo kinetics of vitamin C regarding its stor...