Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11bGr-1 Myeloid-derived Suppressor Cells [0.03%]
拮抗性抗CD137单克隆抗体治疗诱导产生CD11bGr-1髓源抑制细胞
Jung-Mi Lee,Jeong-Hwan Seo,Yeon-Jeong Kim et al.
Jung-Mi Lee et al.
CD137 (4-1BB/tnfrsf9) has been shown to co-stimulate T cells. However, agonistic anti-CD137 monoclonal antibody (mAb) treatment can suppress CD4(+) T cells, ameliorating autoimmune diseases, whereas it induces activation of CD8(+) T cells, ...
GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock [0.03%]
GSK3β抑制肽对脂多糖诱导的小鼠内毒素性休克的保护作用
Ryeojin Ko,Hyun Duk Jang,Soo Young Lee
Ryeojin Ko
Background: Glycogen synthase kinase 3beta (GSK3beta) is a ubiquitous serine/threonine kinase that is regulated by serine phosphorylation at 9. Recent studies have reported the beneficial effects of a number of the pharma...
Cyclooxygenase Inhibitors, Aspirin and Ibuprofen, Inhibit MHC-restricted Antigen Presentation in Dendritic Cells [0.03%]
环氧化酶抑制剂阿司匹林和布洛芬通过抑制树突状细胞中MHC分子限制性抗原的递呈而影响免疫反应
Hyun-Jin Kim,Young-Hee Lee,Sun-A Im et al.
Hyun-Jin Kim et al.
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain, reduce fever and inhibit inflammation. NSAIDs function mainly through inhibition of cyclooxygenase (COX). Growing evidence suggest...
Jiyoung Jang,Dae-Hyoun Lim,In-Hong Choi
Jiyoung Jang
As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity...
A Basten
A Basten
B cells, by virtue of their diverse roles in immune responses to foreign and self antigens, have become of increasing interest to the clinician as well as the basic immunologist. In particular, it is now apparent that the development of B c...
The Production IL-21 and VEGF in UVB-irradiated Human Keratinocyte Cell Line, HaCaT [0.03%]
UVB照射人角质形成细胞系HaCaT中IL-21及VEGF的产生
Hyemin Kim,Jae Seung Kang,Wang Jae Lee
Hyemin Kim
Background: Ultraviolet B (UVB) induces multiple inflammatory and carcinogenic reactions. In skin, UVB induces to secrete several kinds of inflammatory cytokines from keratinocytes and also increases angiogenic process vi...
Polybrominated Diphenyl Ethers Orally Administration to Mice Were Tansferred to Offspring during Gestation and Lactation with Disruptions on the Immune System [0.03%]
多溴二苯醚可通过口服在妊娠和哺乳期间转移给后代并破坏免疫系统
Soon Keun Hong,Kyung Hee Sohn,In Young Kim et al.
Soon Keun Hong et al.
Background: The present study was undertaken to examine the immunological effects of pentabrominated diphenyl ether (penta-BDE) and decabrominated diphenyl ether (deca-BDE) on the immune system of the dams and the develop...
Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB [0.03%]
虫草素通过活化NF-κB促进细胞因子产生从而增强巨噬细胞的免疫刺激作用
Seulmee Shin,Jeonghak Kwon,Sungwon Lee et al.
Seulmee Shin et al.
Background: Cordyceps militaris has been used in traditional medicine to treat numerous diseases and has been reported to possess both antitumor and immunomodulatory activities in vitro and in vivo. However, the pharmacol...
Roles of Host Nonhematopoietic Cells in Autoimmunity and Donor Cell Engraftment in Graft-versus-host Disease [0.03%]
造血干细胞移植中宿主非造血细胞的移植物抗宿主病中的作用机制研究
Juyang Kim,Sohye Park,Hyun-A Kim et al.
Juyang Kim et al.
Background: Graft-versus-host disease (GVHD) is initiated when alloreactive donor T cells are primed by host APCs to undergo clonal expansion and maturation. Since there is a controversy regarding the role of nonhematopoi...
Expression of a Functional zipFv Antibody Fragment and Its Fusions with Alkaline Phosphatase in the Cytoplasm of an Escherichia coli [0.03%]
一种功能性的zipFv抗体片段及其与碱性磷酸酶融合蛋白在大肠杆菌胞液中的表达
Byung-Ung Hur,Hyo-Jung Choi,Jae-Bong Yoon et al.
Byung-Ung Hur et al.
Background: Expression of recombinant antibodies and their derivatives fused with other functional molecules such as alkaline phosphatase in Escherichia coli is important in the development of molecular diagnostic reagent...