Hydrotropic Solubilization by Urea Derivatives: A Molecular Dynamics Simulation Study [0.03%]
尿素衍生物的疏水增溶作用：分子动力学模拟研究
Yong Cui
Yong Cui
Hydrotropy is a phenomenon where the presence of a large quantity of one solute enhances the solubility of another solute. The mechanism of this phenomenon remains a topic of debate. This study employed molecular dynamics simulation to inve...
Seasonal Monitoring of Cardiovascular and Antiulcer Agents' Concentrations in Stream Waters Encompassing a Capital City [0.03%]
涵盖首都地区的季节性监测溪水流中心血管和抗溃疡药物浓度
Renáta Varga,Iván Somogyvári,Zsuzsanna Eke et al.
Renáta Varga et al.
Nowadays monitoring pharmaceutical residues from surface waters is a widespread analytical task. Most of the studies are conducted from river waters or sewage treatment plants and mainly in Western Europe or North America. Such studies are ...
Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement [0.03%]
奥美沙坦酯自微乳化给药系统的制备及其 characterization
Shailesh T Prajapati,Harsh A Joshi,Chhaganbhai N Patel
Shailesh T Prajapati
Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker (ARB) antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility (7.75 μg/ml). The aim of the present investi...
Ufasomes Mediated Cutaneous Delivery of Dexamethasone: Formulation and Evaluation of Anti-Inflammatory Activity by Carrageenin-Induced Rat Paw Edema Model [0.03%]
壳聚糖诱导的大鼠足肿胀模型介导的乌法索姆体内输送氢化可的松及抗炎活性评估
Rajkamal Mittal,Arvind Sharma,Sandeep Arora
Rajkamal Mittal
The purpose of study is to formulate and evaluate ufasomal gel of dexamethasone. Ufasomal suspension was made by sonication method using different concentrations of Span 80, Span 20 and cholesterol along with 25 mg of drug. Ufasomal gel was...
Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug [0.03%]
难溶性药物水性注射液处方开发中混合介导增溶概念的研究
Shailendra Singh Solanki,Love Kumar Soni,Rajesh Kumar Maheshwari
Shailendra Singh Solanki
In the present investigation, mixed-solvency approach has been applied for the enhancement of aqueous solubility of a poorly water- soluble drug, zaltoprofen (selected as a model drug), by making blends (keeping total concentrations 40% w/v...
In Vitro and In Vivo Evaluation of Oxatomide β -Cyclodextrin Inclusion Complex [0.03%]
奥克特莫德-β-环糊精包合物的体内外评价研究
Fahima M Hashem,Mohamed Mostafa,Mahmoud Shaker et al.
Fahima M Hashem et al.
The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug. Oxatomide β-cyclodextrin solid complex was prepared with equimolar ...
Development of Orodispersible Tablets of Candesartan Cilexetil- β -cyclodextrin Complex [0.03%]
卡贝沙坦酯-β-环糊精包合物口服速溶片的研制
Maddukuri Sravya,Rajamanickam Deveswaran,Srinivasan Bharath et al.
Maddukuri Sravya et al.
The aim of this study was to investigate the use of inclusion complexation technique employing β-cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class-II drug, and to formulate the inclusion complex into o...
Quality Assessment of Serially Ultradiluted and Agitated Drug Digitalis purpurea by Emission Spectroscopy and Clinical Analysis of Its Effect on the Heart Rate of Indian Bufo melanostictus [0.03%]
发射光谱与临床分析：药用毛地黄（Digitalis purpurea）的超稀释及振荡性质评估及其对印度黑池蛙（Bufo melanostictus）心率的影响分析
Anup Sharma,Bulbul Purkait
Anup Sharma
The investigation of ultradiluted (homeopathic) drugs is extremely interesting and challenging, and from that point of view this study shows novelty. A study of in vivo changes in heart rate of the Indian Bufo melanostictus caused by commer...
Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with Chitosan/Eudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery [0.03%]
基于Sterculia胶并包衣壳聚糖/ Eudragit RLPO混合聚合物的可能结肠药物递送的凝胶骨架片的设计，开发和优化
Bipul Nath,Lila Kanta Nath
Bipul Nath
The purpose of this study is to explore the possible applicability of Sterculia urens gum as a novel carrier for colonic delivery system of a sparingly soluble drug, azathioprine. The study involves designing a microflora triggered colon-ta...
Solubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method [0.03%]
利用包合物和共研磨方法改善雷洛昔芬溶解度
Payal H Patil,Veena S Belgamwar,Pratibha R Patil et al.
Payal H Patil et al.
The objective of the present work was to enhance the solubility and dissolution of practically water-insoluble drug raloxifene HCl (RLX), for the same two approaches that were used. In the first approach, drug was kneaded with hydroxypropyl...