Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes [0.03%]
氢丙基-β-环糊精包合物达非那fin口腔膜的设计与开发研究
Swati C Jagdale,Prachyasuman Mohanty,Aniruddha R Chabukswar et al.
Swati C Jagdale et al.
Darifenacin is a urinary antispasmodic. The oral absorption of darifenacin is poor due to its low solubility and poor bioavailability (15-19%). Darifenacin was complexed with hydroxylropyl beta-cyclodextrin (Hpβ-CD). The best results were ...
Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs [0.03%]
新型喹唑啉类似物的合成、表征及抗炎活性研究
Chatrasal Singh Rajput,Shiwani Singhal
Chatrasal Singh Rajput
A series of 3-[2'-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5-10), 3-[2'-(3(″)-chloro-2(″)-oxo-4(″)-substitutedphenylazetidin-1(″)-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11-16), and 3-[2...
Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis [0.03%]
用于类风湿性关节炎经时治疗的双重交联脉冲珠的开发与评估
Abanesh Kumar Bansal,Vishal Pande
Abanesh Kumar Bansal
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion pha...
Influence of Air Temperature and Humidity on Dehydration Equilibria and Kinetics of Theophylline [0.03%]
空气温度和湿度对茶碱脱水平衡及动力学的影响
Amira Touil,Roman Peczalski,Souad Timoumi et al.
Amira Touil et al.
The effect of hygrothermal conditions (air temperature and relative humidity) on the dehydration of theophylline monohydrate was investigated. Firstly, the equilibrium states of theophylline were investigated. The data from gravimetric anal...
Biological Atomic Force Microscopy for Imaging Gold-Labeled Liposomes on Human Coronary Artery Endothelial Cells [0.03%]
生物原子力显微镜观察人冠状动脉内皮细胞上的金标记脂质体
Ana-María Zaske,Delia Danila,Michael C Queen et al.
Ana-María Zaske et al.
Although atomic force microscopy (AFM) has been used extensively to characterize cell membrane structure and cellular processes such as endocytosis and exocytosis, the corrugated surface of the cell membrane hinders the visualization of ext...
Analysis of Hydroxy Fatty Acids from the Pollen of Brassica campestris L. var. oleifera DC. by UPLC-MS/MS [0.03%]
UPLC-MS/MS分析菥蓂花粉中的羟基脂肪酸类成分
Nian-Yun Yang,Yi-Fang Yang,Kun Li
Nian-Yun Yang
Ultraperformance liquid chromatography coupled with negative electrospray tandem mass spectrometry (UPLC-ESI-MS/MS) was used to determine 7 hydroxy fatty acids in the pollen of Brassica campestris L. var. oleifera DC. All the investigated h...
Quantum Dot-Loaded Liposomes to Evaluate the Behavior of Drug Carriers after Oral Administration [0.03%]
载量子点的脂质体用于评价口服给药后药物载体的行为
Kohei Tahara,Shiho Fujimoto,Fumihiko Fujii et al.
Kohei Tahara et al.
We have developed submicron-sized liposomes modified with a mucoadhesive polymer to enhance peptide drug absorption after oral administration. Liposomal behavior in the gastrointestinal tract is a critical factor for effective peptide drug ...
Preparation, Characterization, and In Vivo Evaluation of Olanzapine Poly(D,L-lactide-co-glycolide) Microspheres [0.03%]
奥氮平聚(D,L-乳酸-co-乙醇酸)微球的制备、表征及在体评价研究
Susan D&#x;Souza,Jabar A Faraj,Stefano Giovagnoli et al.
Susan D&#x;Souza et al.
The aim of this study was to prepare injectable depot formulations of Olanzapine using four poly(D,L-lactide-co-glycolide) (PLGA) polymers of varying molecular weight and copolymer composition, and evaluate in vivo performance in rats. In v...
Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles [0.03%]
聚乙二醇壳聚糖纳米粒载TAT/MGF标签的siRNA鼻粘膜给药进入大脑
Meenakshi Malhotra,Catherine Tomaro-Duchesneau,Shyamali Saha et al.
Meenakshi Malhotra et al.
Neurodegeneration is characterized by progressive loss of structure and function of neurons. Several therapeutic methods and drugs are available to alleviate the symptoms of these diseases. The currently used delivery strategies such as imp...
Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms [0.03%]
利用电荷转移反应分光光度法测定利培酮及其制剂中的含量
Hemavathi Nagaraju Deepakumari,Hosakere Doddarevanna Revanasiddappa
Hemavathi Nagaraju Deepakumari
The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations. They are based on the charge transfer complex...