Self-Microemulsifying Drug Delivery System: Formulation and Study Intestinal Permeability of Ibuprofen in Rats [0.03%]
自微乳化药物传输系统：制备布洛芬及其大鼠肠道吸收研究
Bharat Bhushan Subudhi,Surjyanarayan Mandal
Bharat Bhushan Subudhi
The study was aimed at developing a self-microemulsifying drug delivery system (SMEDDS) of Ibuprofen for investigating its intestinal transport behavior using the single-pass intestinal perfusion (SPIP) method in rat. Methods. Ibuprofen loa...
Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique [0.03%]
利斯的固体技术改善钙 rosuvastatin 溶解度研究
V J Kapure,V V Pande,P K Deshmukh
V J Kapure
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of d...
HPLC Quantification of Phenolic Acids from Vetiveria zizanioides (L.) Nash and Its Antioxidant and Antimicrobial Activity [0.03%]
香根草中酚酸类成分的含量测定及抗氧化和抑菌活性研究
Jha Prajna,Jindal Richa,Chakraborty Dipjyoti
Jha Prajna
Extraction procedure was standardized and for the soluble, glycoside, and wall-bound fractions of phenolic acids from Vetiveria zizanioides. The water soluble alkaline extract which represents the cell wall-bound fraction contained the high...
Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability [0.03%]
富马酸奎硫平固体脂质纳米粒的制备、表征及改善口服生物利用度的评价
Arjun Narala,Kishan Veerabrahma
Arjun Narala
Quetiapine fumarate is an antipsychotic drug with poor oral bioavailability (9%) due to first-pass metabolism. Present work is an attempt to improve oral bioavailability of quetiapine fumarate by incorporating in solid lipid nanoparticles (...
Cellular Redox Status Regulates Emodin-Induced Radiosensitization of Nasopharyngeal Carcinoma Cells In Vitro and In Vivo [0.03%]
细胞红氧平衡调节番泻苷引起的放射增敏作用(In vitro和In vivo)
Huaxin Hou,Danrong Li,Daohai Cheng et al.
Huaxin Hou et al.
Here, we report that regulation of cellular redox status is required for radiosensitization of nasopharyngeal carcinoma (NPC) cells by emodin. We evaluated emodin's radiosensitivity-enhancing ability by using NPC cells in vitro and xenograf...
Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics [0.03%]
具有无定形状态特性提高溶解度和溶出速率的 Arteether-Soluplus 热熔挤出固态分散系统
Ritesh A Fule,Tarique S Meer,Ajay R Sav et al.
Ritesh A Fule et al.
This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, sing...
Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide: Development, Optimization, and In Vitro-In Vivo Evaluation [0.03%]
用于控制格列本脲释放的植物凝胶浆糊-藻酸盐粘合剂珠粒的开发、优化和体内外评价
Amit Kumar Nayak,Dilipkumar Pal,Kousik Santra
Amit Kumar Nayak
The current study deals with the development and optimization of ispaghula (Plantago ovata F.) husk mucilage- (IHM-) alginate mucoadhesive beads containing glibenclamide by ionotropic gelation technique. The effects of sodium alginate (SA) ...
Transdermal Delivery of Small Interfering RNA with Elastic Cationic Liposomes in Mice [0.03%]
用于小鼠皮肤给药的弹性阳离子脂质体包裹的小干扰RNA疗法
Yoshiyuki Hattori,Masataka Date,Shohei Arai et al.
Yoshiyuki Hattori et al.
We developed elastic cationic liposomal vectors for transdermal siRNA delivery. These liposomes were prepared with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) as a cationic lipid and sodium cholate (NaChol) or Tween 80 as an edge activ...
Preparation and Comparative Bioavailability Studies of Indomethacin-Loaded Cetyl Alcohol Microspheres [0.03%]
制备并对比吲哚美辛卡波姆-硬脂醇微球的体内体外释放及生物利用度研究
N Vishal Gupta,D V Gowda,V Balamuralidhara et al.
N Vishal Gupta et al.
The purpose of the present study was to compare the in vitro release and to find out whether the bioavailability of a 75 mg indomethacin capsule (Microcid SR) was equivalent to optimized formulation (indomethacin-loaded cetyl alcohol micros...
Pentoxifylline Loaded Floating Microballoons: Design, Development and Characterization [0.03%]
氨茶碱载药微囊的制备、开发及表征研究
Prashant Malik,Upendra Nagaich,Raj Kaur Malik et al.
Prashant Malik et al.
The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach. The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to p...