Oxidative stress and inflammation: essential partners in alcoholic liver disease [0.03%]
氧化应激与炎症在酒精性肝病中是必不可少的伙伴
Aditya Ambade,Pranoti Mandrekar
Aditya Ambade
Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated w...
Palepu Jagannath,Deepak Chhabra,Shailesh Shrikhande et al.
Palepu Jagannath et al.
Neuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic ...
Functional Relationships between Lipid Metabolism and Liver Regeneration [0.03%]
脂质代谢与肝再生的相互作用关系研究进展
David A Rudnick,Nicholas O Davidson
David A Rudnick
The regenerative capacity of the liver is well known, and the mechanisms that regulate this process have been extensively studied using experimental model systems including surgical resection and hepatotoxin exposure. The response to primar...
Hepatic arterial embolization for the treatment of metastatic neuroendocrine tumors [0.03%]
肝动脉栓塞治疗转移性神经内分泌肿瘤
Eric Lee,H Leon Pachter,Umut Sarpel
Eric Lee
Neuroendocrine tumors (NETs) have a high predilection for metastasizing to the liver and can cause severe debilitating symptoms adversely affecting quality of life. Although surgery remains the treatment of choice, many liver metastases are...
Ser Yee Lee,Peng Chung Cheow,Jin Yao Teo et al.
Ser Yee Lee et al.
Management of Neuroendocrine liver metastases (NELM) is challenging. The presence of NELM worsens survival outcome and almost 10% of all liver metastases are neuroendocrine in origin. There is no firm consensus on the optimal treatment stra...
Neuroendocrine Liver Metastases and Orthotopic Liver Transplantation: The US Experience [0.03%]
神经内分泌肝转移和自体肝移植（美国经验）
N Thao T Nguyen,Theresa R Harring,John A Goss et al.
N Thao T Nguyen et al.
Liver transplantation remains a controversial therapy for Neuroendocrine liver metastases (NLM), with coflicting suvival data reported. The aim was to assess the evolution of outcomes for patients transplanted for NLM in the US, both before...
Fractalkine and other chemokines in primary biliary cirrhosis [0.03%]
原发性胆汁性肝硬化中的 fractalkine 和其他细胞趋化因子
Shinji Shimoda,Carlo Selmi,M Eric Gershwin
Shinji Shimoda
Primary biliary cirrhosis (PBC) is characterized by the autoimmune injury of small intrahepatic bile duct. On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of auto...
Radioembolization in the treatment of neuroendocrine tumor metastases to the liver [0.03%]
放射性内照射治疗神经内分泌肿瘤肝转移
Martin Vyleta,Douglas Coldwell
Martin Vyleta
Surgical excision remains the preferred treatment for resectable hepatic metastases of neuroendocrine tumors. In cases of more disseminated hepatic disease, transarterial radioembolization with Yttrium-90- (90Y-) labeled microspheres has be...
Emanuele Albano
Emanuele Albano
Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental dat...
Sunil K Taneja,Radha K Dhiman
Sunil K Taneja
Patients with cirrhosis of liver are at risk of developing serious bacterial infections due to altered immune defenses. Despite the widespread use of broad spectrum antibiotics, bacterial infection is responsible for up to a quarter of the ...