Alpha-fetoprotein and novel tumor biomarkers as predictors of hepatocellular carcinoma recurrence after surgery: a brilliant star raises again [0.03%]
甲胎蛋白和新型肿瘤标志物作为手术后肝细胞癌复发预测因素：一个新星再次升起
Quirino Lai,Fabio Melandro,Rafael S Pinheiro et al.
Quirino Lai et al.
Alpha-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) have been developed with the intent to detect hepatocellular carcinoma (HCC) and for the surveillance of at-risk pati...
Etiopathogenesis of nonalcoholic steatohepatitis: role of obesity, insulin resistance and mechanisms of hepatotoxicity [0.03%]
非酒精性脂肪肝病的发病机制：肥胖、胰岛素抵抗以及肝脏毒性的机制作用
Praveen Guturu,Andrea Duchini
Praveen Guturu
Incidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20-30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical t...
Management of anticoagulation for portal vein thrombosis in individuals with cirrhosis: a systematic review [0.03%]
肝硬化个体门静脉血栓的抗凝治疗：系统性回顾
Geneviève Huard,Marc Bilodeau
Geneviève Huard
Non-neoplastic portal vein thrombosis (PVT) is an increasingly recognized complication of liver cirrhosis. It is often diagnosed fortuitously and can be either partial or complete. The clinical significance of PVT is not obvious except in s...
Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis [0.03%]
原发性胆汁性肝硬化患者抗支链α-酮酸脱氢酶E1α亚单位自身抗体的鉴定
Tsutomu Mori,Hiromasa Ohira,Masahito Kuroda et al.
Tsutomu Mori et al.
Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs) that react with the lipoyl-containing E2 subunits of 2-oxoacid dehydrogenase complexes such as BCOADC and PDC. The lipoyl domains of E2 contain the majo...
Noninvasive evaluation of portal hypertension: emerging tools and techniques [0.03%]
评估门脉高压的非侵入性工具与技术：新出现的工具和技巧
V K Snowdon,N Guha,J A Fallowfield
V K Snowdon
Portal hypertension is the main cause of complications in patients with cirrhosis. However, evaluating the development and progression of portal hypertension represents a challenge for clinicians. There has been considerable focus on the po...
Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments [0.03%]
慢性丙型肝炎患者的代谢紊乱和脂肪变性：抗病毒治疗的代谢策略
Munechika Enjoji,Motoyuki Kohjima,Kazuhiro Kotoh et al.
Munechika Enjoji et al.
It has been reported that hepatitis C virus (HCV) infection is closely associated with hepatic metabolic disorders. Hepatic steatosis and insulin resistance are both relatively common in patients with chronic hepatitis C. Recent investigati...
A crucial role of bone morphogenetic protein signaling in the wound healing response in acute liver injury induced by carbon tetrachloride [0.03%]
骨形态发生蛋白信号在四氯化碳致急性肝损伤修复过程中的关键作用研究
Nao Oumi,Kumiko Amano Taniguchi,Ayumi Miyashita Kanai et al.
Nao Oumi et al.
Background. Acute liver injury induced by administration of carbon tetrachloride (CCl(4)) has used a model of wound repair in the rat liver. Previously, we reported transient expression of bone morphogenetic protein (Bmp) 2 or Bmp4 at 6-24 ...
Franck Chiappini
Franck Chiappini
Liver cancer is the fifth most common cancer in men and the seventh in women. During the past 20 years, the incidence of HCC has tripled while the 5-year survival rate has remained below 12%. The presence of circulating tumor cells (CTC) re...
Increased α-Fetoprotein Predicts Steatosis among Patients with Chronic Hepatitis C Genotype 4 [0.03%]
慢性丙型肝炎患者中增加的α-胎儿蛋白预测脂肪变性
Nasser Mousa,Yahia Gad,Azza Abdel-Aziz et al.
Nasser Mousa et al.
Background. The prognostic importance of α-fetoprotein (AFP) level elevation in patients with chronic hepatitis C and its clinical significance in steatosis associated with HCV infection remain to be determined. The present paper assessed ...
Hitoshi Maruyama,Osamu Yokosuka
Hitoshi Maruyama
Esophageal varices are the major complication of portal hypertension. It is detected in about 50% of cirrhosis patients, and approximately 5-15% of cirrhosis patients show newly formed varices or worsening of varices each year. The major th...